PFOS facilitates liver inflammation and steatosis: An involvement of NLRP3 inflammasome‐mediated hepatocyte pyroptosis

Perfluorooctane sulfonate (PFOS) is a fluorinated organic pollutant with substantial accumulation in mammalian liver tissues. However, the impact of chronic PFOS exposure on liver disease progression and the underlying molecular mechanisms remain elusive. Herein, we for the first time revealed that...

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Veröffentlicht in:	Journal of applied toxicology 2022-05, Vol.42 (5), p.806-817
Hauptverfasser:	Qin, Yi, Gu, Tianye, Ling, Junyi, Luo, Jiashan, Zhao, Jianya, Hu, Baoying, Hua, Lu, Wan, Chunhua, Jiang, Shengyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Alkanesulfonic Acids Animals Caspase Exposure Fatty liver Fluorocarbons Hepatocytes hepatotoxicity High fat diet Inflammasomes Inflammasomes - metabolism Inflammation Inflammation - chemically induced Liver Liver - metabolism Liver diseases Mammals - metabolism Metabolic disorders Mice Molecular modelling NLR Family, Pyrin Domain-Containing 3 Protein NLRP3 inflammasome Perfluorooctane sulfonic acid PFOS Pollutants Pyrin protein Pyroptosis Rats Reactive Oxygen Species - metabolism ROS Steatosis
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