Comparison between leukocyte esterase activity and histopathological examination in identifying chorioamnionitis
To compare the sensitivity and specificity of leukocyte esterase activity (LEA) to histopathological examination in diagnosing chorioamnionitis. Methods We compared the diagnostic tests performed at Dr. Mohammad Hoesin Hospital, Palembang, Indonesia, from September 2015 to April 2016. Ninety-one pre...
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| Veröffentlicht in: | Case reports in perinatal medicine 2018-01, Vol.7 (1), p.339 |
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| creator | Novianesari, Putri Healthireza Bernolian, Nuswil Maulani, Henni Ramadanti, Afifa Theodorus |
| description | To compare the sensitivity and specificity of leukocyte esterase activity (LEA) to histopathological examination in diagnosing chorioamnionitis. Methods We compared the diagnostic tests performed at Dr. Mohammad Hoesin Hospital, Palembang, Indonesia, from September 2015 to April 2016. Ninety-one pregnant women were included in the study. The LEA and histopathological examination were carried out with neonatal sepsis the main outcome. Data were analyzed using the SPSS version 21.0 and MedCalc statistics. Results Chorioamnionitis was detected in 54 (77.1%) patients with a gestational age ≥37 weeks and in 16 (22.9%) patients with a gestational age 0.5 was able to significantly predict chorioamnionitis with 98.6% sensitivity and 95.2% specificity, providing better accuracy in diagnosing chorioamnionitis in the preterm pregnancy group. Conclusion LEA had a very good predictive value for chorioamnionitis with better accuracy in diagnosing chorioamnionitis in preterm pregnancy. |
| doi_str_mv | 10.1515/crpm-2017-0045 |
| format | Article |
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Methods We compared the diagnostic tests performed at Dr. Mohammad Hoesin Hospital, Palembang, Indonesia, from September 2015 to April 2016. Ninety-one pregnant women were included in the study. The LEA and histopathological examination were carried out with neonatal sepsis the main outcome. Data were analyzed using the SPSS version 21.0 and MedCalc statistics. Results Chorioamnionitis was detected in 54 (77.1%) patients with a gestational age ≥37 weeks and in 16 (22.9%) patients with a gestational age <37 weeks. The duration of membrane rupture was significantly associated with chorioamnionitis (P = 0.001 and P = 0.011). Neonatal sepsis was also significantly associated with chorioamnionitis in both groups (P = 0.014 and P = 0.036). A LEA value with the cut-off point >0.5 was able to significantly predict chorioamnionitis with 98.6% sensitivity and 95.2% specificity, providing better accuracy in diagnosing chorioamnionitis in the preterm pregnancy group. Conclusion LEA had a very good predictive value for chorioamnionitis with better accuracy in diagnosing chorioamnionitis in preterm pregnancy.</description><identifier>ISSN: 2192-8959</identifier><identifier>ISSN: 2192-8932</identifier><identifier>EISSN: 2192-8959</identifier><identifier>DOI: 10.1515/crpm-2017-0045</identifier><language>eng</language><publisher>Berlin: De Gruyter</publisher><subject>Cardiac arrhythmia ; Case reports ; Chorioamnionitis ; Fetuses ; Gestational age ; histopathology ; Infections ; Laboratories ; leukocyte esterase activity ; Medicine ; Membranes ; Mortality ; neonatal sepsis ; Newborn babies ; Pregnancy ; Salafia criteria ; Secondary schools ; Sepsis ; Vagina ; Womens health</subject><ispartof>Case reports in perinatal medicine, 2018-01, Vol.7 (1), p.339</ispartof><rights>Copyright Walter de Gruyter GmbH 2018</rights><rights>2018 Walter de Gruyter GmbH, Berlin/Boston</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c269t-d8ea639c5e700376276d8d1f9e935922f3f9ab3882eb4c577331964346a28f463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/crpm-2017-0045/pdf$$EPDF$$P50$$Gwalterdegruyter$$H</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/crpm-2017-0045/html$$EHTML$$P50$$Gwalterdegruyter$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,67030,68814</link.rule.ids></links><search><creatorcontrib>Novianesari, Putri Healthireza</creatorcontrib><creatorcontrib>Bernolian, Nuswil</creatorcontrib><creatorcontrib>Maulani, Henni</creatorcontrib><creatorcontrib>Ramadanti, Afifa</creatorcontrib><creatorcontrib>Theodorus</creatorcontrib><title>Comparison between leukocyte esterase activity and histopathological examination in identifying chorioamnionitis</title><title>Case reports in perinatal medicine</title><description>To compare the sensitivity and specificity of leukocyte esterase activity (LEA) to histopathological examination in diagnosing chorioamnionitis. Methods We compared the diagnostic tests performed at Dr. Mohammad Hoesin Hospital, Palembang, Indonesia, from September 2015 to April 2016. Ninety-one pregnant women were included in the study. The LEA and histopathological examination were carried out with neonatal sepsis the main outcome. Data were analyzed using the SPSS version 21.0 and MedCalc statistics. Results Chorioamnionitis was detected in 54 (77.1%) patients with a gestational age ≥37 weeks and in 16 (22.9%) patients with a gestational age <37 weeks. The duration of membrane rupture was significantly associated with chorioamnionitis (P = 0.001 and P = 0.011). Neonatal sepsis was also significantly associated with chorioamnionitis in both groups (P = 0.014 and P = 0.036). A LEA value with the cut-off point >0.5 was able to significantly predict chorioamnionitis with 98.6% sensitivity and 95.2% specificity, providing better accuracy in diagnosing chorioamnionitis in the preterm pregnancy group. Conclusion LEA had a very good predictive value for chorioamnionitis with better accuracy in diagnosing chorioamnionitis in preterm pregnancy.</description><subject>Cardiac arrhythmia</subject><subject>Case reports</subject><subject>Chorioamnionitis</subject><subject>Fetuses</subject><subject>Gestational age</subject><subject>histopathology</subject><subject>Infections</subject><subject>Laboratories</subject><subject>leukocyte esterase activity</subject><subject>Medicine</subject><subject>Membranes</subject><subject>Mortality</subject><subject>neonatal sepsis</subject><subject>Newborn babies</subject><subject>Pregnancy</subject><subject>Salafia criteria</subject><subject>Secondary schools</subject><subject>Sepsis</subject><subject>Vagina</subject><subject>Womens health</subject><issn>2192-8959</issn><issn>2192-8932</issn><issn>2192-8959</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kM1LxDAQxYsouOhePQc8d81X0-Qoi1-w4EXPJZtOd7O2TU1S1_3vTVlBD-IQmCF57w35ZdkVwQtSkOLG-KHLKSZljjEvTrIZJYrmUhXq9Nd8ns1D2OFUUvJ0O8uGpesG7W1wPVpD3AP0qIXxzZlDBAQhgtcBkDbRfth4QLqv0daG6AYdt651G2t0i-BTd7bX0aYUm04NfbTNwfYbZLbOW6e7Pr3ZaMNldtboNsD8u19kr_d3L8vHfPX88LS8XeWGChXzWoIWTJkCSoxZKWgpalmTRoFihaK0YY3SayYlhTU3RVkyRpTgjAtNZcMFu8iuj7mDd-9j-ki1c6Pv08qKCi4UwzR5_lNhJhinWBVJtTiqjHcheGiqwdtO-0NFcDXhryb81YS_mvAngzwa9rpNBGvY-DHx9D_pfxtLwr4AeuCNFQ</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Novianesari, Putri Healthireza</creator><creator>Bernolian, Nuswil</creator><creator>Maulani, Henni</creator><creator>Ramadanti, Afifa</creator><creator>Theodorus</creator><general>De Gruyter</general><general>Walter de Gruyter GmbH</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20180101</creationdate><title>Comparison between leukocyte esterase activity and histopathological examination in identifying chorioamnionitis</title><author>Novianesari, Putri Healthireza ; Bernolian, Nuswil ; Maulani, Henni ; Ramadanti, Afifa ; Theodorus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c269t-d8ea639c5e700376276d8d1f9e935922f3f9ab3882eb4c577331964346a28f463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cardiac arrhythmia</topic><topic>Case reports</topic><topic>Chorioamnionitis</topic><topic>Fetuses</topic><topic>Gestational age</topic><topic>histopathology</topic><topic>Infections</topic><topic>Laboratories</topic><topic>leukocyte esterase activity</topic><topic>Medicine</topic><topic>Membranes</topic><topic>Mortality</topic><topic>neonatal sepsis</topic><topic>Newborn babies</topic><topic>Pregnancy</topic><topic>Salafia criteria</topic><topic>Secondary schools</topic><topic>Sepsis</topic><topic>Vagina</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Novianesari, Putri Healthireza</creatorcontrib><creatorcontrib>Bernolian, Nuswil</creatorcontrib><creatorcontrib>Maulani, Henni</creatorcontrib><creatorcontrib>Ramadanti, Afifa</creatorcontrib><creatorcontrib>Theodorus</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Case reports in perinatal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Novianesari, Putri Healthireza</au><au>Bernolian, Nuswil</au><au>Maulani, Henni</au><au>Ramadanti, Afifa</au><au>Theodorus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison between leukocyte esterase activity and histopathological examination in identifying chorioamnionitis</atitle><jtitle>Case reports in perinatal medicine</jtitle><date>2018-01-01</date><risdate>2018</risdate><volume>7</volume><issue>1</issue><spage>339</spage><pages>339-</pages><issn>2192-8959</issn><issn>2192-8932</issn><eissn>2192-8959</eissn><abstract>To compare the sensitivity and specificity of leukocyte esterase activity (LEA) to histopathological examination in diagnosing chorioamnionitis. Methods We compared the diagnostic tests performed at Dr. Mohammad Hoesin Hospital, Palembang, Indonesia, from September 2015 to April 2016. Ninety-one pregnant women were included in the study. The LEA and histopathological examination were carried out with neonatal sepsis the main outcome. Data were analyzed using the SPSS version 21.0 and MedCalc statistics. Results Chorioamnionitis was detected in 54 (77.1%) patients with a gestational age ≥37 weeks and in 16 (22.9%) patients with a gestational age <37 weeks. The duration of membrane rupture was significantly associated with chorioamnionitis (P = 0.001 and P = 0.011). Neonatal sepsis was also significantly associated with chorioamnionitis in both groups (P = 0.014 and P = 0.036). A LEA value with the cut-off point >0.5 was able to significantly predict chorioamnionitis with 98.6% sensitivity and 95.2% specificity, providing better accuracy in diagnosing chorioamnionitis in the preterm pregnancy group. Conclusion LEA had a very good predictive value for chorioamnionitis with better accuracy in diagnosing chorioamnionitis in preterm pregnancy.</abstract><cop>Berlin</cop><pub>De Gruyter</pub><doi>10.1515/crpm-2017-0045</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Case reports in perinatal medicine, 2018-01, Vol.7 (1), p.339 |
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| subjects | Cardiac arrhythmia Case reports Chorioamnionitis Fetuses Gestational age histopathology Infections Laboratories leukocyte esterase activity Medicine Membranes Mortality neonatal sepsis Newborn babies Pregnancy Salafia criteria Secondary schools Sepsis Vagina Womens health |
| title | Comparison between leukocyte esterase activity and histopathological examination in identifying chorioamnionitis |
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