Versatile Synthesis of rac‐ and meso‐Hydroxymethyl Cyclohexenoids Containing Phenyl Groups: α‐/β‐Glucosidase Activities, Inhibition Kinetics and Molecular Docking Studies

The effective strategy has been developed to synthesize a series of monophenyl and diphenyl carbasugar analogues, from the cycloadduct reaction of furan and maleic anhydride, containing halogen groups based on the conduritol scaffold. The strategy mainly consists of reduction, esterification, bromin...

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Veröffentlicht in:	European journal of organic chemistry 2022-04, Vol.2022 (13), p.n/a
Hauptverfasser:	Sevmezler, Sedat, Çol, Sümeyye, Emirik, Mustafa, Ceylan, Davut, Baran, Arif
Format:	Artikel
Sprache:	eng
Schlagworte:	Bromination Bromine Coupling (molecular) Docking studies Esterification Esters Glucosidase Hydroxymethyl cyclohexane In vitro methods and tests Inhibition kinetics Maleic anhydride Molecular docking Structure-activity relationships Synthesis design
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