Oral Adrenergic Agents Produced Ventricular Fibrillation and QT Prolongation in an Elderly Patient Carrying an RYR2 Variant
Mutant cardiac ryanodine receptor channels (RyR2) are "leaky," and spontaneous Ca2+ release through these channels causes delayed afterdepolarizations that can deteriorate into ventricular fibrillation. Some patients carrying RYR2 mutations in type 1 catecholaminergic polymorphic ventricul...
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| Veröffentlicht in: | International Heart Journal 2022/03/30, Vol.63(2), pp.398-403 |
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| container_title | International Heart Journal |
| container_volume | 63 |
| creator | Hasegawa, Kanae Gao, Jingshan Ohno, Seiko Ishida, Kentaro Miyazaki, Shinsuke Makiyama, Takeru Horie, Minoru Uzui, Hiroyasu Tada, Hiroshi |
| description | Mutant cardiac ryanodine receptor channels (RyR2) are "leaky," and spontaneous Ca2+ release through these channels causes delayed afterdepolarizations that can deteriorate into ventricular fibrillation. Some patients carrying RYR2 mutations in type 1 catecholaminergic polymorphic ventricular tachycardia exhibit QT prolongation and are initially diagnosed with long QT syndrome. However, none have been reported to cause drug-induced ventricular fibrillation in patients with RYR2 variants. We describe the first case of an elderly woman with drug-induced QT prolongation and ventricular fibrillation who carried a novel RYR2 variant but no other mutations related to long QT syndrome. Oral adrenergic agents might induce QT prolongation and subsequent ventricular fibrillation in patients carrying an RYR2 variant. Screening for RYR2 could be valuable in patients with suspected drug-induced long QT syndrome. |
| doi_str_mv | 10.1536/ihj.21-543 |
| format | Article |
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Some patients carrying RYR2 mutations in type 1 catecholaminergic polymorphic ventricular tachycardia exhibit QT prolongation and are initially diagnosed with long QT syndrome. However, none have been reported to cause drug-induced ventricular fibrillation in patients with RYR2 variants. We describe the first case of an elderly woman with drug-induced QT prolongation and ventricular fibrillation who carried a novel RYR2 variant but no other mutations related to long QT syndrome. Oral adrenergic agents might induce QT prolongation and subsequent ventricular fibrillation in patients carrying an RYR2 variant. Screening for RYR2 could be valuable in patients with suspected drug-induced long QT syndrome.</description><identifier>ISSN: 1349-2365</identifier><identifier>EISSN: 1349-3299</identifier><identifier>DOI: 10.1536/ihj.21-543</identifier><identifier>PMID: 35354758</identifier><language>eng</language><publisher>Japan: International Heart Journal Association</publisher><subject>Adrenergic Agents ; Aged ; Calcium channels ; Cardiac arrhythmia ; Cardiac ryanodine receptor ; Defibrillators ; Drug ; Female ; Fibrillation ; Humans ; Long QT syndrome ; Long QT Syndrome - chemically induced ; Long QT Syndrome - diagnosis ; Long QT Syndrome - genetics ; Mutation ; Receptor channels ; Ryanodine Receptor Calcium Release Channel - genetics ; Ryanodine receptors ; Tachycardia ; Tachycardia, Ventricular - chemically induced ; Tachycardia, Ventricular - diagnosis ; Tachycardia, Ventricular - genetics ; Ventricle ; Ventricular Fibrillation - chemically induced ; Ventricular Fibrillation - diagnosis</subject><ispartof>International Heart Journal, 2022/03/30, Vol.63(2), pp.398-403</ispartof><rights>2022 by the International Heart Journal Association</rights><rights>Copyright Japan Science and Technology Agency 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c514t-79ce256d372a09b876227ac94e6b9ebbbac53846c24eaaf949fefa108ec9f1e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35354758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasegawa, Kanae</creatorcontrib><creatorcontrib>Gao, Jingshan</creatorcontrib><creatorcontrib>Ohno, Seiko</creatorcontrib><creatorcontrib>Ishida, Kentaro</creatorcontrib><creatorcontrib>Miyazaki, Shinsuke</creatorcontrib><creatorcontrib>Makiyama, Takeru</creatorcontrib><creatorcontrib>Horie, Minoru</creatorcontrib><creatorcontrib>Uzui, Hiroyasu</creatorcontrib><creatorcontrib>Tada, Hiroshi</creatorcontrib><title>Oral Adrenergic Agents Produced Ventricular Fibrillation and QT Prolongation in an Elderly Patient Carrying an RYR2 Variant</title><title>International Heart Journal</title><addtitle>Int. Heart J.</addtitle><description>Mutant cardiac ryanodine receptor channels (RyR2) are "leaky," and spontaneous Ca2+ release through these channels causes delayed afterdepolarizations that can deteriorate into ventricular fibrillation. Some patients carrying RYR2 mutations in type 1 catecholaminergic polymorphic ventricular tachycardia exhibit QT prolongation and are initially diagnosed with long QT syndrome. However, none have been reported to cause drug-induced ventricular fibrillation in patients with RYR2 variants. We describe the first case of an elderly woman with drug-induced QT prolongation and ventricular fibrillation who carried a novel RYR2 variant but no other mutations related to long QT syndrome. Oral adrenergic agents might induce QT prolongation and subsequent ventricular fibrillation in patients carrying an RYR2 variant. Screening for RYR2 could be valuable in patients with suspected drug-induced long QT syndrome.</description><subject>Adrenergic Agents</subject><subject>Aged</subject><subject>Calcium channels</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac ryanodine receptor</subject><subject>Defibrillators</subject><subject>Drug</subject><subject>Female</subject><subject>Fibrillation</subject><subject>Humans</subject><subject>Long QT syndrome</subject><subject>Long QT Syndrome - chemically induced</subject><subject>Long QT Syndrome - diagnosis</subject><subject>Long QT Syndrome - genetics</subject><subject>Mutation</subject><subject>Receptor channels</subject><subject>Ryanodine Receptor Calcium Release Channel - genetics</subject><subject>Ryanodine receptors</subject><subject>Tachycardia</subject><subject>Tachycardia, Ventricular - chemically induced</subject><subject>Tachycardia, Ventricular - diagnosis</subject><subject>Tachycardia, Ventricular - genetics</subject><subject>Ventricle</subject><subject>Ventricular Fibrillation - chemically induced</subject><subject>Ventricular Fibrillation - diagnosis</subject><issn>1349-2365</issn><issn>1349-3299</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtr3DAUhUVpaNKkm_6AIugu4NR62tp1GJImEMiDJNCVkOVrR4Mip9f2Yuifr-bR2Ui653z3CA4hX1l5wZTQP8Lr6oKzQknxgZwwIU0huDEf928utDomn8dxVZaSqbL6RI6FEkpWqj4hf-_QRbpoERJgHzxd9JCmkd7j0M4eWvqSRwx-jg7pVWgwxOimMCTqUksfnjZgHFK_08JGppexBYxrep_FvE2XDnEdUr_xHn8_cvriMLg0nZGjzsURvuzvU_J8dfm0vC5u737dLBe3hVdMTkVlPHClW1FxV5qmrjTnlfNGgm4MNE3jvBK11J5LcK4z0nTQOVbW4E3HgIlT8n2X-47DnxnGya6GGVP-0nItNVO6ZjxT5zvK4zCOCJ19x_DmcG1ZaTc929yz5czmnjP8bR85N2_QHtD_xWbg5w5YjZPr4QA4nIKPsM3SwvLtsc08WP7VoYUk_gEd5JDi</recordid><startdate>20220330</startdate><enddate>20220330</enddate><creator>Hasegawa, Kanae</creator><creator>Gao, Jingshan</creator><creator>Ohno, Seiko</creator><creator>Ishida, Kentaro</creator><creator>Miyazaki, Shinsuke</creator><creator>Makiyama, Takeru</creator><creator>Horie, Minoru</creator><creator>Uzui, Hiroyasu</creator><creator>Tada, Hiroshi</creator><general>International Heart Journal Association</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope></search><sort><creationdate>20220330</creationdate><title>Oral Adrenergic Agents Produced Ventricular Fibrillation and QT Prolongation in an Elderly Patient Carrying an RYR2 Variant</title><author>Hasegawa, Kanae ; Gao, Jingshan ; Ohno, Seiko ; Ishida, Kentaro ; Miyazaki, Shinsuke ; Makiyama, Takeru ; Horie, Minoru ; Uzui, Hiroyasu ; Tada, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-79ce256d372a09b876227ac94e6b9ebbbac53846c24eaaf949fefa108ec9f1e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adrenergic Agents</topic><topic>Aged</topic><topic>Calcium channels</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac ryanodine receptor</topic><topic>Defibrillators</topic><topic>Drug</topic><topic>Female</topic><topic>Fibrillation</topic><topic>Humans</topic><topic>Long QT syndrome</topic><topic>Long QT Syndrome - chemically induced</topic><topic>Long QT Syndrome - diagnosis</topic><topic>Long QT Syndrome - genetics</topic><topic>Mutation</topic><topic>Receptor channels</topic><topic>Ryanodine Receptor Calcium Release Channel - genetics</topic><topic>Ryanodine receptors</topic><topic>Tachycardia</topic><topic>Tachycardia, Ventricular - chemically induced</topic><topic>Tachycardia, Ventricular - diagnosis</topic><topic>Tachycardia, Ventricular - genetics</topic><topic>Ventricle</topic><topic>Ventricular Fibrillation - chemically induced</topic><topic>Ventricular Fibrillation - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasegawa, Kanae</creatorcontrib><creatorcontrib>Gao, Jingshan</creatorcontrib><creatorcontrib>Ohno, Seiko</creatorcontrib><creatorcontrib>Ishida, Kentaro</creatorcontrib><creatorcontrib>Miyazaki, Shinsuke</creatorcontrib><creatorcontrib>Makiyama, Takeru</creatorcontrib><creatorcontrib>Horie, Minoru</creatorcontrib><creatorcontrib>Uzui, Hiroyasu</creatorcontrib><creatorcontrib>Tada, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>International Heart Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasegawa, Kanae</au><au>Gao, Jingshan</au><au>Ohno, Seiko</au><au>Ishida, Kentaro</au><au>Miyazaki, Shinsuke</au><au>Makiyama, Takeru</au><au>Horie, Minoru</au><au>Uzui, Hiroyasu</au><au>Tada, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral Adrenergic Agents Produced Ventricular Fibrillation and QT Prolongation in an Elderly Patient Carrying an RYR2 Variant</atitle><jtitle>International Heart Journal</jtitle><addtitle>Int. Heart J.</addtitle><date>2022-03-30</date><risdate>2022</risdate><volume>63</volume><issue>2</issue><spage>398</spage><epage>403</epage><pages>398-403</pages><artnum>21-543</artnum><issn>1349-2365</issn><eissn>1349-3299</eissn><abstract>Mutant cardiac ryanodine receptor channels (RyR2) are "leaky," and spontaneous Ca2+ release through these channels causes delayed afterdepolarizations that can deteriorate into ventricular fibrillation. Some patients carrying RYR2 mutations in type 1 catecholaminergic polymorphic ventricular tachycardia exhibit QT prolongation and are initially diagnosed with long QT syndrome. However, none have been reported to cause drug-induced ventricular fibrillation in patients with RYR2 variants. We describe the first case of an elderly woman with drug-induced QT prolongation and ventricular fibrillation who carried a novel RYR2 variant but no other mutations related to long QT syndrome. Oral adrenergic agents might induce QT prolongation and subsequent ventricular fibrillation in patients carrying an RYR2 variant. Screening for RYR2 could be valuable in patients with suspected drug-induced long QT syndrome.</abstract><cop>Japan</cop><pub>International Heart Journal Association</pub><pmid>35354758</pmid><doi>10.1536/ihj.21-543</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenergic Agents Aged Calcium channels Cardiac arrhythmia Cardiac ryanodine receptor Defibrillators Drug Female Fibrillation Humans Long QT syndrome Long QT Syndrome - chemically induced Long QT Syndrome - diagnosis Long QT Syndrome - genetics Mutation Receptor channels Ryanodine Receptor Calcium Release Channel - genetics Ryanodine receptors Tachycardia Tachycardia, Ventricular - chemically induced Tachycardia, Ventricular - diagnosis Tachycardia, Ventricular - genetics Ventricle Ventricular Fibrillation - chemically induced Ventricular Fibrillation - diagnosis |
| title | Oral Adrenergic Agents Produced Ventricular Fibrillation and QT Prolongation in an Elderly Patient Carrying an RYR2 Variant |
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