Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model of Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive deterioration of cognitive abilities, accumulation of the amyloid-β-peptide (Aβ) and synaptic alterations. Treatment with lithium has been shown to provide neuroprotection against several insults, including...

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Veröffentlicht in:	Molecular psychiatry 2010-03, Vol.15 (3), p.272-285
Hauptverfasser:	Toledo, E M, Inestrosa, N C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Astrocytes Behavioral Sciences Biochemical analysis Biological Psychology Cellular signal transduction Cognitive ability Dosage and administration Drug therapy Gene deletion Glycogen Glycogen synthase kinase 3 Health aspects Inflammation Kinases Lithium Medicine Medicine & Public Health Memory Microglia Neurodegeneration Neurodegenerative diseases Neuroprotection Neurosciences Neurotoxicity original-article Peptides Pharmacotherapy Presenilin 1 Psychiatry Rosiglitazone Rosiglitazone maleate Signal transduction Spatial memory Transgenic mice Wnt protein β-Amyloid β-Catenin
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