Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence

Anatomical, pharmacological and human post-mortem studies suggest the dopamine D 3 receptor (DRD3) gene as a candidate for drug dependence. We thus performed an association study of the Bal I polymorphism at the DRD3 gene, including 54 opiate addicts and 70 controls. Opiate addicts had a higher sens...

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Veröffentlicht in:	Molecular psychiatry 1998-07, Vol.3 (4), p.333-336
Hauptverfasser:	Duaux, E, Gorwood, P, Griffon, N, Bourdel, M-C, Sautel, F, Sokoloff, P, Schwartz, J-C, Ades, J, Lôo, H, Poirier, M-F
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictive behaviors Addicts Adult Adult and adolescent clinical studies Behavioral Sciences Biological and medical sciences Biological Psychology Deoxyribonucleases, Type II Site-Specific Dopamine Dopamine D3 receptors Drug abuse Drug addiction Drug dependence France Gene polymorphism Genotype Homozygote Homozygotes Humans Male Medical sciences Medicine Medicine & Public Health Morbidity Narcotics Neurosciences Opioid-Related Disorders - epidemiology Opioid-Related Disorders - genetics original-research-article Personality - genetics Pharmacotherapy Polymerase Chain Reaction Polymorphism Polymorphism, Restriction Fragment Length Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Dopamine D2 - genetics Receptors, Dopamine D3 Reference Values Sensation
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