Novel epigenetic mechanisms that control pluripotency and quiescence of adult bone marrow-derived Oct4+ very small embryonic-like stem cells

Recently, we identified in adult tissues a population of Oct4 + SSEA-1 + Sca-1 + lin − CD45 − very small embryonic-like stem cells (VSELs). First, to address recent controversies on Oct4 expression in cells isolated from adult organs, we show here evidence that Oct4 promoter in bone marrow (BM)-deri...

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Veröffentlicht in:	Leukemia 2009-11, Vol.23 (11), p.2042-2051
Hauptverfasser:	Shin, D M, Zuba-Surma, E K, Wu, W, Ratajczak, J, Wysoczynski, M, Ratajczak, M Z, Kucia, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Stem Cells - cytology Adult Stem Cells - physiology Animals Biological and medical sciences Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - physiology Cancer Research CD45 antigen Cell differentiation Chromatin Chromatin - physiology Critical Care Medicine DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA methylation DNA Methylation - physiology DNA Methyltransferase 3A DNA Methyltransferase 3B Embryo cells Embryos Epigenesis, Genetic - physiology Epigenetics Female Gene Expression Profiling Genes Genomic Imprinting - physiology Hematologic and hematopoietic diseases Hematology Insulin-like growth factor II Intensive Internal Medicine Laboratory animals Leukemia Male Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Transgenic Oct-4 protein Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Oncology Organs original-article Pluripotency Pluripotent Stem Cells - cytology Pluripotent Stem Cells - physiology Promoter Regions, Genetic - physiology Regenerative medicine Stem cells Teratoma Tissue engineering
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