Risk factors of myelodysplastic syndromes: a case-control study
Little is known about the etiology of myelodysplastic syndromes (MDS). A hospital-based case-control study of 354 adult de novo MDS cases and 452 controls was conducted to investigate associations between lifestyle characteristics and MDS risk. The distribution by French-American-British (FAB) type...
Gespeichert in:
| Veröffentlicht in: | Leukemia 2005-11, Vol.19 (11), p.1912-1918 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1918 |
|---|---|
| container_issue | 11 |
| container_start_page | 1912 |
| container_title | Leukemia |
| container_volume | 19 |
| creator | STROM, S. S GU, Y GRUSCHKUS, S. K PIERCE, S. A ESTEY, E. H |
| description | Little is known about the etiology of myelodysplastic syndromes (MDS). A hospital-based case-control study of 354 adult de novo MDS cases and 452 controls was conducted to investigate associations between lifestyle characteristics and MDS risk. The distribution by French-American-British (FAB) type was 67 (19%) refractory anemia (RA), 38 (11%) refractory anemia with ringed sideroblasts (RARS), 43 (12%) chronic myelomonocytic leukemia (CMML), 136 (38%) RA with excess blasts (RAEB), and 70 (20%) RAEB in transformation (RAEBT). Multivariate logistic regression analyses were performed among all MDS cases and among each FAB type and gender. For all MDS combined, family history of hematopoietic cancer (odds ratio (OR) = 1.92), smoking (OR = 1.65), and exposure to agricultural chemicals (OR = 4.55) or solvents (OR = 2.05) were associated with MDS risk. Among RA/RARS cases, smoking (OR = 2.23) and agricultural chemical exposure (OR = 5.68) were the only risk factors identified. For RAEB/RAEBT cases, family history of hematopoietic cancer (OR = 2.10), smoking (OR = 1.52), and exposure to agricultural chemicals (OR = 3.79) or solvents (OR = 2.71) were independent risk factors. Drinking wine reduced risk for all FAB types by almost 50% (OR = 0.54). We found a joint effect between smoking and chemical exposure with the highest risk among smokers exposed to solvents/agricultural chemicals (OR = 3.22). Results from this large study suggest that several factors play a role in MDS predisposition with possible joint effects. Risk profiles seem to differ by FAB type and gender. |
| doi_str_mv | 10.1038/sj.leu.2403945 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2645715425</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A188524703</galeid><sourcerecordid>A188524703</sourcerecordid><originalsourceid>FETCH-LOGICAL-c564t-7290cb8edbe3733caf6ee74c465f3ab211585a9871101b24f0aa0b4d08f8c8c3</originalsourceid><addsrcrecordid>eNp1kc1rFTEUxYNY7LO6dacMit3NM8nka7qRUtQWCoJ0HzKZxOY5M3nmZhbz35tHR59CJYtA7u-cy8lB6BXBW4Ib9QF228HNW8pw0zL-BG0Ik6LmnJOnaIOVkrVoKTtFzwF2GB-G4hk6JYIIiXm7QR-_BfhReWNzTFBFX42LG2K_wH4wkIOtYJn6FEcHF5WprAFX2zjlFIcK8twvL9CJNwO4l-t9hu4-f7q7uq5vv365ubq8rS0XLNeStth2yvWda2TTWOOFc5JZJrhvTEcJ4YqbVklCMOko89gY3LEeK6-sss0Zevdgu0_x5-wg612c01Q2aioYl4Qzygv19r8UxZyzlrCj1XczOB0mH3Mydgxg9SVRilMmcVOo7SNUOb0bQ_kB50N5_0dw_pfg3pkh30Mc5hziBI862xQBkvN6n8Jo0qIJ1odONex06VSvnRbBmzXV3I2uP-JriQV4vwIGrBl8MpMNcORkyU7xIfnrB24yeU7uD_B70S_fNrCU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220554914</pqid></control><display><type>article</type><title>Risk factors of myelodysplastic syndromes: a case-control study</title><source>MEDLINE</source><source>Nature</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>STROM, S. S ; GU, Y ; GRUSCHKUS, S. K ; PIERCE, S. A ; ESTEY, E. H</creator><creatorcontrib>STROM, S. S ; GU, Y ; GRUSCHKUS, S. K ; PIERCE, S. A ; ESTEY, E. H</creatorcontrib><description>Little is known about the etiology of myelodysplastic syndromes (MDS). A hospital-based case-control study of 354 adult de novo MDS cases and 452 controls was conducted to investigate associations between lifestyle characteristics and MDS risk. The distribution by French-American-British (FAB) type was 67 (19%) refractory anemia (RA), 38 (11%) refractory anemia with ringed sideroblasts (RARS), 43 (12%) chronic myelomonocytic leukemia (CMML), 136 (38%) RA with excess blasts (RAEB), and 70 (20%) RAEB in transformation (RAEBT). Multivariate logistic regression analyses were performed among all MDS cases and among each FAB type and gender. For all MDS combined, family history of hematopoietic cancer (odds ratio (OR) = 1.92), smoking (OR = 1.65), and exposure to agricultural chemicals (OR = 4.55) or solvents (OR = 2.05) were associated with MDS risk. Among RA/RARS cases, smoking (OR = 2.23) and agricultural chemical exposure (OR = 5.68) were the only risk factors identified. For RAEB/RAEBT cases, family history of hematopoietic cancer (OR = 2.10), smoking (OR = 1.52), and exposure to agricultural chemicals (OR = 3.79) or solvents (OR = 2.71) were independent risk factors. Drinking wine reduced risk for all FAB types by almost 50% (OR = 0.54). We found a joint effect between smoking and chemical exposure with the highest risk among smokers exposed to solvents/agricultural chemicals (OR = 3.22). Results from this large study suggest that several factors play a role in MDS predisposition with possible joint effects. Risk profiles seem to differ by FAB type and gender.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/sj.leu.2403945</identifier><identifier>PMID: 16167059</identifier><identifier>CODEN: LEUKED</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Agricultural chemicals ; Agrochemicals ; Anemia ; Biological and medical sciences ; Blast cells ; Cancer ; Case-Control Studies ; Chemicals ; Chronic myelomonocytic leukemia ; Disorders ; Environmental Exposure ; Etiology ; Exposure ; Family medical history ; Female ; Gender ; Genetic Predisposition to Disease ; Genetics ; Hematologic and hematopoietic diseases ; Humans ; Leukemia ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Life Style ; Male ; Medical sciences ; Middle Aged ; Myelodysplastic syndrome ; Myelodysplastic syndromes ; Myelodysplastic Syndromes - etiology ; Myelodysplastic Syndromes - genetics ; Myelomonocytic leukemia ; Odds Ratio ; Pesticides - poisoning ; Refractory anemia ; Regression analysis ; Risk analysis ; Risk assessment ; Risk Factors ; Risk management ; Risk reduction ; Sex Factors ; Sideroblasts ; Smoking ; Smoking - adverse effects ; Solvents ; Solvents - poisoning ; Wines</subject><ispartof>Leukemia, 2005-11, Vol.19 (11), p.1912-1918</ispartof><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Nov 2005</rights><rights>Nature Publishing Group 2005.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-7290cb8edbe3733caf6ee74c465f3ab211585a9871101b24f0aa0b4d08f8c8c3</citedby><cites>FETCH-LOGICAL-c564t-7290cb8edbe3733caf6ee74c465f3ab211585a9871101b24f0aa0b4d08f8c8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17205204$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16167059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STROM, S. S</creatorcontrib><creatorcontrib>GU, Y</creatorcontrib><creatorcontrib>GRUSCHKUS, S. K</creatorcontrib><creatorcontrib>PIERCE, S. A</creatorcontrib><creatorcontrib>ESTEY, E. H</creatorcontrib><title>Risk factors of myelodysplastic syndromes: a case-control study</title><title>Leukemia</title><addtitle>Leukemia</addtitle><description>Little is known about the etiology of myelodysplastic syndromes (MDS). A hospital-based case-control study of 354 adult de novo MDS cases and 452 controls was conducted to investigate associations between lifestyle characteristics and MDS risk. The distribution by French-American-British (FAB) type was 67 (19%) refractory anemia (RA), 38 (11%) refractory anemia with ringed sideroblasts (RARS), 43 (12%) chronic myelomonocytic leukemia (CMML), 136 (38%) RA with excess blasts (RAEB), and 70 (20%) RAEB in transformation (RAEBT). Multivariate logistic regression analyses were performed among all MDS cases and among each FAB type and gender. For all MDS combined, family history of hematopoietic cancer (odds ratio (OR) = 1.92), smoking (OR = 1.65), and exposure to agricultural chemicals (OR = 4.55) or solvents (OR = 2.05) were associated with MDS risk. Among RA/RARS cases, smoking (OR = 2.23) and agricultural chemical exposure (OR = 5.68) were the only risk factors identified. For RAEB/RAEBT cases, family history of hematopoietic cancer (OR = 2.10), smoking (OR = 1.52), and exposure to agricultural chemicals (OR = 3.79) or solvents (OR = 2.71) were independent risk factors. Drinking wine reduced risk for all FAB types by almost 50% (OR = 0.54). We found a joint effect between smoking and chemical exposure with the highest risk among smokers exposed to solvents/agricultural chemicals (OR = 3.22). Results from this large study suggest that several factors play a role in MDS predisposition with possible joint effects. Risk profiles seem to differ by FAB type and gender.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Agricultural chemicals</subject><subject>Agrochemicals</subject><subject>Anemia</subject><subject>Biological and medical sciences</subject><subject>Blast cells</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Chemicals</subject><subject>Chronic myelomonocytic leukemia</subject><subject>Disorders</subject><subject>Environmental Exposure</subject><subject>Etiology</subject><subject>Exposure</subject><subject>Family medical history</subject><subject>Female</subject><subject>Gender</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Life Style</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myelodysplastic syndrome</subject><subject>Myelodysplastic syndromes</subject><subject>Myelodysplastic Syndromes - etiology</subject><subject>Myelodysplastic Syndromes - genetics</subject><subject>Myelomonocytic leukemia</subject><subject>Odds Ratio</subject><subject>Pesticides - poisoning</subject><subject>Refractory anemia</subject><subject>Regression analysis</subject><subject>Risk analysis</subject><subject>Risk assessment</subject><subject>Risk Factors</subject><subject>Risk management</subject><subject>Risk reduction</subject><subject>Sex Factors</subject><subject>Sideroblasts</subject><subject>Smoking</subject><subject>Smoking - adverse effects</subject><subject>Solvents</subject><subject>Solvents - poisoning</subject><subject>Wines</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc1rFTEUxYNY7LO6dacMit3NM8nka7qRUtQWCoJ0HzKZxOY5M3nmZhbz35tHR59CJYtA7u-cy8lB6BXBW4Ib9QF228HNW8pw0zL-BG0Ik6LmnJOnaIOVkrVoKTtFzwF2GB-G4hk6JYIIiXm7QR-_BfhReWNzTFBFX42LG2K_wH4wkIOtYJn6FEcHF5WprAFX2zjlFIcK8twvL9CJNwO4l-t9hu4-f7q7uq5vv365ubq8rS0XLNeStth2yvWda2TTWOOFc5JZJrhvTEcJ4YqbVklCMOko89gY3LEeK6-sss0Zevdgu0_x5-wg612c01Q2aioYl4Qzygv19r8UxZyzlrCj1XczOB0mH3Mydgxg9SVRilMmcVOo7SNUOb0bQ_kB50N5_0dw_pfg3pkh30Mc5hziBI862xQBkvN6n8Jo0qIJ1odONex06VSvnRbBmzXV3I2uP-JriQV4vwIGrBl8MpMNcORkyU7xIfnrB24yeU7uD_B70S_fNrCU</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>STROM, S. S</creator><creator>GU, Y</creator><creator>GRUSCHKUS, S. K</creator><creator>PIERCE, S. A</creator><creator>ESTEY, E. H</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20051101</creationdate><title>Risk factors of myelodysplastic syndromes: a case-control study</title><author>STROM, S. S ; GU, Y ; GRUSCHKUS, S. K ; PIERCE, S. A ; ESTEY, E. H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c564t-7290cb8edbe3733caf6ee74c465f3ab211585a9871101b24f0aa0b4d08f8c8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Agricultural chemicals</topic><topic>Agrochemicals</topic><topic>Anemia</topic><topic>Biological and medical sciences</topic><topic>Blast cells</topic><topic>Cancer</topic><topic>Case-Control Studies</topic><topic>Chemicals</topic><topic>Chronic myelomonocytic leukemia</topic><topic>Disorders</topic><topic>Environmental Exposure</topic><topic>Etiology</topic><topic>Exposure</topic><topic>Family medical history</topic><topic>Female</topic><topic>Gender</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Life Style</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myelodysplastic syndrome</topic><topic>Myelodysplastic syndromes</topic><topic>Myelodysplastic Syndromes - etiology</topic><topic>Myelodysplastic Syndromes - genetics</topic><topic>Myelomonocytic leukemia</topic><topic>Odds Ratio</topic><topic>Pesticides - poisoning</topic><topic>Refractory anemia</topic><topic>Regression analysis</topic><topic>Risk analysis</topic><topic>Risk assessment</topic><topic>Risk Factors</topic><topic>Risk management</topic><topic>Risk reduction</topic><topic>Sex Factors</topic><topic>Sideroblasts</topic><topic>Smoking</topic><topic>Smoking - adverse effects</topic><topic>Solvents</topic><topic>Solvents - poisoning</topic><topic>Wines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STROM, S. S</creatorcontrib><creatorcontrib>GU, Y</creatorcontrib><creatorcontrib>GRUSCHKUS, S. K</creatorcontrib><creatorcontrib>PIERCE, S. A</creatorcontrib><creatorcontrib>ESTEY, E. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Leukemia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STROM, S. S</au><au>GU, Y</au><au>GRUSCHKUS, S. K</au><au>PIERCE, S. A</au><au>ESTEY, E. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors of myelodysplastic syndromes: a case-control study</atitle><jtitle>Leukemia</jtitle><addtitle>Leukemia</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>19</volume><issue>11</issue><spage>1912</spage><epage>1918</epage><pages>1912-1918</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><coden>LEUKED</coden><abstract>Little is known about the etiology of myelodysplastic syndromes (MDS). A hospital-based case-control study of 354 adult de novo MDS cases and 452 controls was conducted to investigate associations between lifestyle characteristics and MDS risk. The distribution by French-American-British (FAB) type was 67 (19%) refractory anemia (RA), 38 (11%) refractory anemia with ringed sideroblasts (RARS), 43 (12%) chronic myelomonocytic leukemia (CMML), 136 (38%) RA with excess blasts (RAEB), and 70 (20%) RAEB in transformation (RAEBT). Multivariate logistic regression analyses were performed among all MDS cases and among each FAB type and gender. For all MDS combined, family history of hematopoietic cancer (odds ratio (OR) = 1.92), smoking (OR = 1.65), and exposure to agricultural chemicals (OR = 4.55) or solvents (OR = 2.05) were associated with MDS risk. Among RA/RARS cases, smoking (OR = 2.23) and agricultural chemical exposure (OR = 5.68) were the only risk factors identified. For RAEB/RAEBT cases, family history of hematopoietic cancer (OR = 2.10), smoking (OR = 1.52), and exposure to agricultural chemicals (OR = 3.79) or solvents (OR = 2.71) were independent risk factors. Drinking wine reduced risk for all FAB types by almost 50% (OR = 0.54). We found a joint effect between smoking and chemical exposure with the highest risk among smokers exposed to solvents/agricultural chemicals (OR = 3.22). Results from this large study suggest that several factors play a role in MDS predisposition with possible joint effects. Risk profiles seem to differ by FAB type and gender.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>16167059</pmid><doi>10.1038/sj.leu.2403945</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0887-6924 |
| ispartof | Leukemia, 2005-11, Vol.19 (11), p.1912-1918 |
| issn | 0887-6924 1476-5551 |
| language | eng |
| recordid | cdi_proquest_journals_2645715425 |
| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Agricultural chemicals Agrochemicals Anemia Biological and medical sciences Blast cells Cancer Case-Control Studies Chemicals Chronic myelomonocytic leukemia Disorders Environmental Exposure Etiology Exposure Family medical history Female Gender Genetic Predisposition to Disease Genetics Hematologic and hematopoietic diseases Humans Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Life Style Male Medical sciences Middle Aged Myelodysplastic syndrome Myelodysplastic syndromes Myelodysplastic Syndromes - etiology Myelodysplastic Syndromes - genetics Myelomonocytic leukemia Odds Ratio Pesticides - poisoning Refractory anemia Regression analysis Risk analysis Risk assessment Risk Factors Risk management Risk reduction Sex Factors Sideroblasts Smoking Smoking - adverse effects Solvents Solvents - poisoning Wines |
| title | Risk factors of myelodysplastic syndromes: a case-control study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T10%3A49%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Risk%20factors%20of%20myelodysplastic%20syndromes:%20a%20case-control%20study&rft.jtitle=Leukemia&rft.au=STROM,%20S.%20S&rft.date=2005-11-01&rft.volume=19&rft.issue=11&rft.spage=1912&rft.epage=1918&rft.pages=1912-1918&rft.issn=0887-6924&rft.eissn=1476-5551&rft.coden=LEUKED&rft_id=info:doi/10.1038/sj.leu.2403945&rft_dat=%3Cgale_proqu%3EA188524703%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=220554914&rft_id=info:pmid/16167059&rft_galeid=A188524703&rfr_iscdi=true |