Therapy-related leukemia : clinical characteristics and analysis of new molecular risk factors in 96 adult patients

Therapy-related leukemia or myelodysplasia (t-leuk/MDS) is a serious problem that is increasing in frequency. We studied the clinical characteristics of 96 patients (pts) with a mean age of 48 years, and analyzed the molecular parameters that could predispose to t-leuk/MDS. Hematological malignancie...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Leukemia 2005-11, Vol.19 (11), p.1919-1928
Hauptverfasser:	RUND, D, KRICHEVSKY, S, BAR-COHEN, S, GOLDSCHMIDT, N, KEDMI, M, MALIK, E, GURAL, A, SHAFRAN-TIKVA, S, BEN-NERIAH, S, BEN-YEHUDA, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Adaptor Proteins, Signal Transducing Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Breast cancer Carrier Proteins Cell division Chemotherapy Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - genetics Cytogenetics DNA damage DNA repair Drug metabolism Epigenetics Etiology Female Gene polymorphism Genes, MDR Genetic Predisposition to Disease Hematologic and hematopoietic diseases Hematology Hospitals Humans Immunohistochemistry Karyotypes Karyotyping Latency Leukemia Leukemia - chemically induced Leukemia - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male MDR1 protein Medical prognosis Medical sciences Metabolism Microsatellite instability Microsatellite Repeats Middle Aged MLH1 protein MSH2 protein MutL Protein Homolog 1 Myelodysplastic syndrome Myelodysplastic syndromes Myelodysplastic Syndromes - chemically induced Myelodysplastic Syndromes - genetics NAD Neoplasm Proteins - genetics Neoplasms, Second Primary - chemically induced Neoplasms, Second Primary - genetics Nuclear Proteins - genetics Ovarian cancer Patients Polymerase Chain Reaction Polymorphism Prognosis Quinones Radiation therapy Retrospective Studies Ribosomal Protein S6 Kinases, 90-kDa - genetics Risk analysis Risk Factors Stability analysis Survival Analysis Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!