Frequent expression of HAGE in presentation chronic myeloid leukaemias
Cancer testis (CT) antigens provide attractive targets for cancer-specific immunotherapy. Although CT genes are expressed in some normal tissues, such as the testis and in some cases placenta, these immunologically protected sites lack MHC I expression and as such, do not present 'self' an...
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| Veröffentlicht in: | Leukemia 2002-11, Vol.16 (11), p.2238-2242 |
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| creator | ADAMS, S. P SAHOTA, S. S MIJOVIC, A CZEPULKOWSKI, B PADUA, R. A MUFTI, C. J GUINN, B. A |
| description | Cancer testis (CT) antigens provide attractive targets for cancer-specific immunotherapy. Although CT genes are expressed in some normal tissues, such as the testis and in some cases placenta, these immunologically protected sites lack MHC I expression and as such, do not present 'self' antigens to T cells. To date, CT genes have been shown to be expressed in a range of solid tumours, but rarely in haematological malignancies. We have extended previous studies to investigate the expression of a comprehensive range of CT genes (MAGE-A1, -A3, -A6, -A12, BAGE, GAGE, HAGE,LAGE-1, NY-ESO-1 and RAGE) for their expression in a cohort of acute and chronic myeloid leukaemia patient samples. CT expression was not detected in 20 normal bone marrow or peripheral blood stem cell samples. In acute myeloid leukaemia (AML) nine of the 26 (35%) samples analysed expressed one or more of the CT genes with six of the samples (23%) expressing HAGE. In chronic myeloid leukaemia (CML) 24 of 42 (57%) presentation chronic myeloid leukaemia (CML) patient samples expressed one or more CT antigen with 23 expressing HAGE. We have shown that HAGE is frequently expressed in CML, and to a lesser extent in AML patient samples. This is the first demonstration of HAGE gene expression in myeloid leukaemia patients and the frequent expression of HAGE at disease presentation opens up the possibility of early immunotherapeutic treatments. |
| doi_str_mv | 10.1038/sj.leu.2402732 |
| format | Article |
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P ; SAHOTA, S. S ; MIJOVIC, A ; CZEPULKOWSKI, B ; PADUA, R. A ; MUFTI, C. J ; GUINN, B. A</creator><creatorcontrib>ADAMS, S. P ; SAHOTA, S. S ; MIJOVIC, A ; CZEPULKOWSKI, B ; PADUA, R. A ; MUFTI, C. J ; GUINN, B. A</creatorcontrib><description>Cancer testis (CT) antigens provide attractive targets for cancer-specific immunotherapy. Although CT genes are expressed in some normal tissues, such as the testis and in some cases placenta, these immunologically protected sites lack MHC I expression and as such, do not present 'self' antigens to T cells. To date, CT genes have been shown to be expressed in a range of solid tumours, but rarely in haematological malignancies. We have extended previous studies to investigate the expression of a comprehensive range of CT genes (MAGE-A1, -A3, -A6, -A12, BAGE, GAGE, HAGE,LAGE-1, NY-ESO-1 and RAGE) for their expression in a cohort of acute and chronic myeloid leukaemia patient samples. CT expression was not detected in 20 normal bone marrow or peripheral blood stem cell samples. In acute myeloid leukaemia (AML) nine of the 26 (35%) samples analysed expressed one or more of the CT genes with six of the samples (23%) expressing HAGE. In chronic myeloid leukaemia (CML) 24 of 42 (57%) presentation chronic myeloid leukaemia (CML) patient samples expressed one or more CT antigen with 23 expressing HAGE. We have shown that HAGE is frequently expressed in CML, and to a lesser extent in AML patient samples. This is the first demonstration of HAGE gene expression in myeloid leukaemia patients and the frequent expression of HAGE at disease presentation opens up the possibility of early immunotherapeutic treatments.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/sj.leu.2402732</identifier><identifier>PMID: 12399967</identifier><identifier>CODEN: LEUKED</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Acute myeloid leukemia ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antigen presentation ; Antigens ; Antigens, Neoplasm - genetics ; Autoantigens ; Biological and medical sciences ; Bone marrow ; Bone Marrow Cells - physiology ; Cancer ; Care and treatment ; Case-Control Studies ; Chronic myeloid leukemia ; DEAD-box RNA Helicases ; DNA Helicases ; DNA, Neoplasm - analysis ; Gene expression ; Gene Expression Regulation, Neoplastic ; Genes ; Genetic aspects ; HAGE gene ; Health aspects ; Hematologic and hematopoietic diseases ; Hematopoietic stem cells ; Humans ; Immunotherapy ; Leukemia ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphocytes ; Lymphocytes T ; Major histocompatibility complex ; Male ; Medical sciences ; Middle Aged ; Neoplasm Proteins - genetics ; Peripheral blood ; Placenta ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Neoplasm - metabolism ; Solid tumors ; Stem cells ; Testis - metabolism ; Testis - pathology ; Tumor antigens ; Tumor Cells, Cultured ; Tumors</subject><ispartof>Leukemia, 2002-11, Vol.16 (11), p.2238-2242</ispartof><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2002 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Nov 2002</rights><rights>Macmillan Publishers Limited 2002.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-1e882fba022559087b2922954a0d8e290dcf2da6ba3deb2b9b21f93d989470cc3</citedby><cites>FETCH-LOGICAL-c443t-1e882fba022559087b2922954a0d8e290dcf2da6ba3deb2b9b21f93d989470cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13999158$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12399967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ADAMS, S. P</creatorcontrib><creatorcontrib>SAHOTA, S. S</creatorcontrib><creatorcontrib>MIJOVIC, A</creatorcontrib><creatorcontrib>CZEPULKOWSKI, B</creatorcontrib><creatorcontrib>PADUA, R. A</creatorcontrib><creatorcontrib>MUFTI, C. J</creatorcontrib><creatorcontrib>GUINN, B. A</creatorcontrib><title>Frequent expression of HAGE in presentation chronic myeloid leukaemias</title><title>Leukemia</title><addtitle>Leukemia</addtitle><description>Cancer testis (CT) antigens provide attractive targets for cancer-specific immunotherapy. Although CT genes are expressed in some normal tissues, such as the testis and in some cases placenta, these immunologically protected sites lack MHC I expression and as such, do not present 'self' antigens to T cells. To date, CT genes have been shown to be expressed in a range of solid tumours, but rarely in haematological malignancies. We have extended previous studies to investigate the expression of a comprehensive range of CT genes (MAGE-A1, -A3, -A6, -A12, BAGE, GAGE, HAGE,LAGE-1, NY-ESO-1 and RAGE) for their expression in a cohort of acute and chronic myeloid leukaemia patient samples. CT expression was not detected in 20 normal bone marrow or peripheral blood stem cell samples. In acute myeloid leukaemia (AML) nine of the 26 (35%) samples analysed expressed one or more of the CT genes with six of the samples (23%) expressing HAGE. In chronic myeloid leukaemia (CML) 24 of 42 (57%) presentation chronic myeloid leukaemia (CML) patient samples expressed one or more CT antigen with 23 expressing HAGE. We have shown that HAGE is frequently expressed in CML, and to a lesser extent in AML patient samples. This is the first demonstration of HAGE gene expression in myeloid leukaemia patients and the frequent expression of HAGE at disease presentation opens up the possibility of early immunotherapeutic treatments.</description><subject>Acute myeloid leukemia</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigen presentation</subject><subject>Antigens</subject><subject>Antigens, Neoplasm - genetics</subject><subject>Autoantigens</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells - physiology</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Chronic myeloid leukemia</subject><subject>DEAD-box RNA Helicases</subject><subject>DNA Helicases</subject><subject>DNA, Neoplasm - analysis</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>HAGE gene</subject><subject>Health aspects</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Leukemia</subject><subject>Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics</subject><subject>Leukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Major histocompatibility complex</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - genetics</subject><subject>Peripheral blood</subject><subject>Placenta</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Neoplasm - metabolism</subject><subject>Solid tumors</subject><subject>Stem cells</subject><subject>Testis - metabolism</subject><subject>Testis - pathology</subject><subject>Tumor antigens</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUtr3DAUhUVJaSZpt1kGk9DuPJWubD2WQ8gkhUA37VrIstTRxLYmkg3Jv49MDZNCihaCc7977guhC4LXBFPxPe3XnZ3WUGHgFD6gFak4K-u6JidohYXgJZNQnaKzlPYYz0H2CZ0SoFJKxldou432abLDWNjnQ7Qp-TAUwRX3m7vbwg_FrOWoHmfd7GIYvCn6F9sF3xa58qO2vdfpM_rodJfsl-U_R7-3t79u7suHn3c_bjYPpakqOpbECgGu0RigriUWvAEJIOtK41ZYkLg1DlrNGk1b20AjGyBO0lYKWXFsDD1H1399DzHkttOo9mGKQy6pgFU1x1xInqmr_1KACZOSiqPVH91Z5QcXxqhN75NRmwwJxjDFmVq_Q-XX5rlNGKzzWf8n4dubhJ3V3bhLoZvmBaZ3nU0MKUXr1CH6XscXRbCab6vSXuUNq-W2OeFymWpqetse8eWYGfi6ADoZ3bmoB-PTkZsxUgv6CotHqVg</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>ADAMS, S. 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Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Major histocompatibility complex</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - genetics</topic><topic>Peripheral blood</topic><topic>Placenta</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Neoplasm - metabolism</topic><topic>Solid tumors</topic><topic>Stem cells</topic><topic>Testis - metabolism</topic><topic>Testis - pathology</topic><topic>Tumor antigens</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ADAMS, S. P</creatorcontrib><creatorcontrib>SAHOTA, S. S</creatorcontrib><creatorcontrib>MIJOVIC, A</creatorcontrib><creatorcontrib>CZEPULKOWSKI, B</creatorcontrib><creatorcontrib>PADUA, R. A</creatorcontrib><creatorcontrib>MUFTI, C. 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P</au><au>SAHOTA, S. S</au><au>MIJOVIC, A</au><au>CZEPULKOWSKI, B</au><au>PADUA, R. A</au><au>MUFTI, C. J</au><au>GUINN, B. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequent expression of HAGE in presentation chronic myeloid leukaemias</atitle><jtitle>Leukemia</jtitle><addtitle>Leukemia</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>16</volume><issue>11</issue><spage>2238</spage><epage>2242</epage><pages>2238-2242</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><coden>LEUKED</coden><abstract>Cancer testis (CT) antigens provide attractive targets for cancer-specific immunotherapy. Although CT genes are expressed in some normal tissues, such as the testis and in some cases placenta, these immunologically protected sites lack MHC I expression and as such, do not present 'self' antigens to T cells. To date, CT genes have been shown to be expressed in a range of solid tumours, but rarely in haematological malignancies. We have extended previous studies to investigate the expression of a comprehensive range of CT genes (MAGE-A1, -A3, -A6, -A12, BAGE, GAGE, HAGE,LAGE-1, NY-ESO-1 and RAGE) for their expression in a cohort of acute and chronic myeloid leukaemia patient samples. CT expression was not detected in 20 normal bone marrow or peripheral blood stem cell samples. In acute myeloid leukaemia (AML) nine of the 26 (35%) samples analysed expressed one or more of the CT genes with six of the samples (23%) expressing HAGE. In chronic myeloid leukaemia (CML) 24 of 42 (57%) presentation chronic myeloid leukaemia (CML) patient samples expressed one or more CT antigen with 23 expressing HAGE. We have shown that HAGE is frequently expressed in CML, and to a lesser extent in AML patient samples. This is the first demonstration of HAGE gene expression in myeloid leukaemia patients and the frequent expression of HAGE at disease presentation opens up the possibility of early immunotherapeutic treatments.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>12399967</pmid><doi>10.1038/sj.leu.2402732</doi><tpages>5</tpages></addata></record> |
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| subjects | Acute myeloid leukemia Adolescent Adult Aged Aged, 80 and over Antigen presentation Antigens Antigens, Neoplasm - genetics Autoantigens Biological and medical sciences Bone marrow Bone Marrow Cells - physiology Cancer Care and treatment Case-Control Studies Chronic myeloid leukemia DEAD-box RNA Helicases DNA Helicases DNA, Neoplasm - analysis Gene expression Gene Expression Regulation, Neoplastic Genes Genetic aspects HAGE gene Health aspects Hematologic and hematopoietic diseases Hematopoietic stem cells Humans Immunotherapy Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes Lymphocytes T Major histocompatibility complex Male Medical sciences Middle Aged Neoplasm Proteins - genetics Peripheral blood Placenta Reverse Transcriptase Polymerase Chain Reaction RNA, Neoplasm - metabolism Solid tumors Stem cells Testis - metabolism Testis - pathology Tumor antigens Tumor Cells, Cultured Tumors |
| title | Frequent expression of HAGE in presentation chronic myeloid leukaemias |
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