Photobiomodulation therapy preconditioning modifies nitric oxide pathway and oxidative stress in human-induced pluripotent stem cell-derived ventricular cardiomyocytes treated with doxorubicin
Doxorubicin (DOX) is an anthracycline antibiotic that exhibits high heart toxicity. Human-induced pluripotent stem cell-derived ventricular cardiomyocytes (hiPSC-vCMs) are important in vitro models for testing drug cardiotoxicity. Photobiomodulation therapy (PBMT) is a non-invasive therapy that stim...
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| Veröffentlicht in: | Lasers in medical science 2022-04, Vol.37 (3), p.1667-1675 |
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| creator | Atum, Allan Luís Barboza da Silva, José Almir Alves Marques, Danila Prates, Renato Araújo Consolim-Colombo, Fernanda Marciano Irigoyen, Maria Cláudia Costa Dalboni, Maria Aparecida Chavantes, Maria Cristina Silva, José Antônio |
| description | Doxorubicin (DOX) is an anthracycline antibiotic that exhibits high heart toxicity. Human-induced pluripotent stem cell-derived ventricular cardiomyocytes (hiPSC-vCMs) are important in vitro models for testing drug cardiotoxicity. Photobiomodulation therapy (PBMT) is a non-invasive therapy that stimulates cells growth and self-repair using light irradiation. This study aimed to investigate the in vitro effects of PBMT preconditioning on cardiotoxicity induced by DOX. HiPSC-vCMs were treated with PBMT for 500 s, followed by the addition of 2 μM DOX. LED irradiation preconditioning parameters were at 660 nm with an irradiance of 10 mW/cm
2
, performing 5 J/cm
2
, followed by 24-h DOX exposure (2 μM). Human iPSC-vCMs treated with 2 μM DOX or irradiated with PBMT composed the second and third groups, respectively. The control group did neither receive PBMT preconditioning nor DOX and was irradiated with a white standard lamp. Cells from all groups were collected to perform mRNA and miRNA expressions quantification. PBMT, when applied before the DOX challenge, restored the viability of hiPSC-vCMs and reduced ROS levels. Although downregulated by DOX, myocardial UCP2 mRNA expression presented marked upregulation after PBMT preconditioning. Expression of eNOS and UCP2 mRNA and NO production were decreased after DOX exposure, and PBMT preconditioning before the DOX challenge reversed these changes. Moreover, our data indicated that PBMT preconditioning lowered the miR-24 expression. Our data suggested that PBMT preconditioning ameliorated in vitro DOX-induced cardiotoxicity on transcription level, restoring NO levels and reducing oxidative stress. |
| doi_str_mv | 10.1007/s10103-021-03416-9 |
| format | Article |
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2
, performing 5 J/cm
2
, followed by 24-h DOX exposure (2 μM). Human iPSC-vCMs treated with 2 μM DOX or irradiated with PBMT composed the second and third groups, respectively. The control group did neither receive PBMT preconditioning nor DOX and was irradiated with a white standard lamp. Cells from all groups were collected to perform mRNA and miRNA expressions quantification. PBMT, when applied before the DOX challenge, restored the viability of hiPSC-vCMs and reduced ROS levels. Although downregulated by DOX, myocardial UCP2 mRNA expression presented marked upregulation after PBMT preconditioning. Expression of eNOS and UCP2 mRNA and NO production were decreased after DOX exposure, and PBMT preconditioning before the DOX challenge reversed these changes. Moreover, our data indicated that PBMT preconditioning lowered the miR-24 expression. Our data suggested that PBMT preconditioning ameliorated in vitro DOX-induced cardiotoxicity on transcription level, restoring NO levels and reducing oxidative stress.</description><identifier>ISSN: 1435-604X</identifier><identifier>ISSN: 0268-8921</identifier><identifier>EISSN: 1435-604X</identifier><identifier>DOI: 10.1007/s10103-021-03416-9</identifier><identifier>PMID: 34536182</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Anthracycline ; Antibiotics ; Cardiomyocytes ; Cardiotoxicity ; Dentistry ; Doxorubicin ; Gene expression ; Human influences ; Irradiance ; Irradiation ; Lasers ; Light irradiation ; Light therapy ; Medicine ; Medicine & Public Health ; miRNA ; Mitochondrial uncoupling protein 2 ; Nitric oxide ; Optical Devices ; Optics ; Original Article ; Oxidative stress ; Photonics ; Pluripotency ; Preconditioning ; Quantum Optics ; Radiation ; Stem cells ; Therapy ; Toxicity ; Transcription ; Ventricle</subject><ispartof>Lasers in medical science, 2022-04, Vol.37 (3), p.1667-1675</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-88373ce0889f8e67ab36312685ae44e096c31f3beee2ba10c1ab28caaa85fb13</citedby><cites>FETCH-LOGICAL-c375t-88373ce0889f8e67ab36312685ae44e096c31f3beee2ba10c1ab28caaa85fb13</cites><orcidid>0000-0001-6904-9185</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10103-021-03416-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10103-021-03416-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34536182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Atum, Allan Luís Barboza</creatorcontrib><creatorcontrib>da Silva, José Almir Alves</creatorcontrib><creatorcontrib>Marques, Danila</creatorcontrib><creatorcontrib>Prates, Renato Araújo</creatorcontrib><creatorcontrib>Consolim-Colombo, Fernanda Marciano</creatorcontrib><creatorcontrib>Irigoyen, Maria Cláudia Costa</creatorcontrib><creatorcontrib>Dalboni, Maria Aparecida</creatorcontrib><creatorcontrib>Chavantes, Maria Cristina</creatorcontrib><creatorcontrib>Silva, José Antônio</creatorcontrib><title>Photobiomodulation therapy preconditioning modifies nitric oxide pathway and oxidative stress in human-induced pluripotent stem cell-derived ventricular cardiomyocytes treated with doxorubicin</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><addtitle>Lasers Med Sci</addtitle><description>Doxorubicin (DOX) is an anthracycline antibiotic that exhibits high heart toxicity. Human-induced pluripotent stem cell-derived ventricular cardiomyocytes (hiPSC-vCMs) are important in vitro models for testing drug cardiotoxicity. Photobiomodulation therapy (PBMT) is a non-invasive therapy that stimulates cells growth and self-repair using light irradiation. This study aimed to investigate the in vitro effects of PBMT preconditioning on cardiotoxicity induced by DOX. HiPSC-vCMs were treated with PBMT for 500 s, followed by the addition of 2 μM DOX. LED irradiation preconditioning parameters were at 660 nm with an irradiance of 10 mW/cm
2
, performing 5 J/cm
2
, followed by 24-h DOX exposure (2 μM). Human iPSC-vCMs treated with 2 μM DOX or irradiated with PBMT composed the second and third groups, respectively. The control group did neither receive PBMT preconditioning nor DOX and was irradiated with a white standard lamp. Cells from all groups were collected to perform mRNA and miRNA expressions quantification. PBMT, when applied before the DOX challenge, restored the viability of hiPSC-vCMs and reduced ROS levels. Although downregulated by DOX, myocardial UCP2 mRNA expression presented marked upregulation after PBMT preconditioning. Expression of eNOS and UCP2 mRNA and NO production were decreased after DOX exposure, and PBMT preconditioning before the DOX challenge reversed these changes. Moreover, our data indicated that PBMT preconditioning lowered the miR-24 expression. Our data suggested that PBMT preconditioning ameliorated in vitro DOX-induced cardiotoxicity on transcription level, restoring NO levels and reducing oxidative stress.</description><subject>Anthracycline</subject><subject>Antibiotics</subject><subject>Cardiomyocytes</subject><subject>Cardiotoxicity</subject><subject>Dentistry</subject><subject>Doxorubicin</subject><subject>Gene expression</subject><subject>Human influences</subject><subject>Irradiance</subject><subject>Irradiation</subject><subject>Lasers</subject><subject>Light irradiation</subject><subject>Light therapy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>miRNA</subject><subject>Mitochondrial uncoupling protein 2</subject><subject>Nitric oxide</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Original Article</subject><subject>Oxidative stress</subject><subject>Photonics</subject><subject>Pluripotency</subject><subject>Preconditioning</subject><subject>Quantum Optics</subject><subject>Radiation</subject><subject>Stem cells</subject><subject>Therapy</subject><subject>Toxicity</subject><subject>Transcription</subject><subject>Ventricle</subject><issn>1435-604X</issn><issn>0268-8921</issn><issn>1435-604X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kctu1jAQRiMEoqXwAiyQJdYudpw4zhJVFCpVgkUX7CzHnjSuEjvYTtu8HY_GtH-5rFjZmjlzZqSvqt5ydsoZ6z5kzjgTlNWcMtFwSftn1TFvREsla74__-d_VL3K-YYx3kkuXlZHommF5Ko-rn5-m2KJg49LdNtsio-BlAmSWXeyJrAxOP9Q9OGaIOJHD5kEX5K3JN57B2Q1ZbozOzHBPVbQcQsklwQ5Ex_ItC0mUB_cZsGRdd6SX2OBUJCBhViYZ-og4ZAjt1hGMx6SiDXJ4Vl7tHvBnegzBZE7Xybi4n1M2-CtD6-rF6OZM7x5ek-qq_NPV2df6OXXzxdnHy-pFV1bqFKiExaYUv2oQHZmEFLwWqrWQNMA66UVfBQDANSD4cxyM9TKGmNUOw5cnFTvD9o1xR8b5KJv4pYCbtS1bFrZo1kgVR8om2LOCUa9Jr-YtGvO9ENm-pCZxsz0Y2a6x6F3T-ptWMD9GfkdEgLiAGRshWtIf3f_R_sL9d6p8A</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Atum, Allan Luís Barboza</creator><creator>da Silva, José 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therapy preconditioning modifies nitric oxide pathway and oxidative stress in human-induced pluripotent stem cell-derived ventricular cardiomyocytes treated with doxorubicin</title><author>Atum, Allan Luís Barboza ; da Silva, José Almir Alves ; Marques, Danila ; Prates, Renato Araújo ; Consolim-Colombo, Fernanda Marciano ; Irigoyen, Maria Cláudia Costa ; Dalboni, Maria Aparecida ; Chavantes, Maria Cristina ; Silva, José Antônio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-88373ce0889f8e67ab36312685ae44e096c31f3beee2ba10c1ab28caaa85fb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anthracycline</topic><topic>Antibiotics</topic><topic>Cardiomyocytes</topic><topic>Cardiotoxicity</topic><topic>Dentistry</topic><topic>Doxorubicin</topic><topic>Gene expression</topic><topic>Human 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Sci</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>37</volume><issue>3</issue><spage>1667</spage><epage>1675</epage><pages>1667-1675</pages><issn>1435-604X</issn><issn>0268-8921</issn><eissn>1435-604X</eissn><abstract>Doxorubicin (DOX) is an anthracycline antibiotic that exhibits high heart toxicity. Human-induced pluripotent stem cell-derived ventricular cardiomyocytes (hiPSC-vCMs) are important in vitro models for testing drug cardiotoxicity. Photobiomodulation therapy (PBMT) is a non-invasive therapy that stimulates cells growth and self-repair using light irradiation. This study aimed to investigate the in vitro effects of PBMT preconditioning on cardiotoxicity induced by DOX. HiPSC-vCMs were treated with PBMT for 500 s, followed by the addition of 2 μM DOX. LED irradiation preconditioning parameters were at 660 nm with an irradiance of 10 mW/cm
2
, performing 5 J/cm
2
, followed by 24-h DOX exposure (2 μM). Human iPSC-vCMs treated with 2 μM DOX or irradiated with PBMT composed the second and third groups, respectively. The control group did neither receive PBMT preconditioning nor DOX and was irradiated with a white standard lamp. Cells from all groups were collected to perform mRNA and miRNA expressions quantification. PBMT, when applied before the DOX challenge, restored the viability of hiPSC-vCMs and reduced ROS levels. Although downregulated by DOX, myocardial UCP2 mRNA expression presented marked upregulation after PBMT preconditioning. Expression of eNOS and UCP2 mRNA and NO production were decreased after DOX exposure, and PBMT preconditioning before the DOX challenge reversed these changes. Moreover, our data indicated that PBMT preconditioning lowered the miR-24 expression. Our data suggested that PBMT preconditioning ameliorated in vitro DOX-induced cardiotoxicity on transcription level, restoring NO levels and reducing oxidative stress.</abstract><cop>London</cop><pub>Springer London</pub><pmid>34536182</pmid><doi>10.1007/s10103-021-03416-9</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6904-9185</orcidid></addata></record> |
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| ispartof | Lasers in medical science, 2022-04, Vol.37 (3), p.1667-1675 |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Anthracycline Antibiotics Cardiomyocytes Cardiotoxicity Dentistry Doxorubicin Gene expression Human influences Irradiance Irradiation Lasers Light irradiation Light therapy Medicine Medicine & Public Health miRNA Mitochondrial uncoupling protein 2 Nitric oxide Optical Devices Optics Original Article Oxidative stress Photonics Pluripotency Preconditioning Quantum Optics Radiation Stem cells Therapy Toxicity Transcription Ventricle |
| title | Photobiomodulation therapy preconditioning modifies nitric oxide pathway and oxidative stress in human-induced pluripotent stem cell-derived ventricular cardiomyocytes treated with doxorubicin |
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