Efficacy and safety of flexible-dose oral sildenafil citrate (Viagra) in the treatment of erectile dysfunction in Brazilian and Mexican men
A 12-week, double-blind, placebo-controlled, multicenter study evaluated the efficacy and safety of flexible-dose sildenafil citrate (Viagra) treatment (25, 50 or 100 mg) in Brazilian and Mexican men with erectile dysfunction (ED) of broad-spectrum etiology. Efficacy was assessed on the basis of res...
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| Veröffentlicht in: | International journal of impotence research 2002-08, Vol.14 Suppl 2 (S2), p.S27-S32 |
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| creator | Glina, S Bertero, E Claro, J Damião, R Faria, G Fregonesi, A Jaspersen, J Mendoza, A Mattos, Jr, D Rocha, L C Sotomayor, M Telöken, C Ureta, S Zonana, E Ugarte, F |
| description | A 12-week, double-blind, placebo-controlled, multicenter study evaluated the efficacy and safety of flexible-dose sildenafil citrate (Viagra) treatment (25, 50 or 100 mg) in Brazilian and Mexican men with erectile dysfunction (ED) of broad-spectrum etiology. Efficacy was assessed on the basis of responses to the 15-item International Index of Erectile Function (IIEF) questionnaire, completed at baseline and after 12 weeks of treatment. At end point, mean scores for all IIEF domains of sexual function (erectile function, orgasmic function, sexual desire, intercourse satisfaction and overall satisfaction) were significantly (P |
| doi_str_mv | 10.1038/sj.ijir.3900895 |
| format | Article |
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Efficacy was assessed on the basis of responses to the 15-item International Index of Erectile Function (IIEF) questionnaire, completed at baseline and after 12 weeks of treatment. At end point, mean scores for all IIEF domains of sexual function (erectile function, orgasmic function, sexual desire, intercourse satisfaction and overall satisfaction) were significantly (P<0.0001) higher in the sildenafil group (n=109) than in the placebo group (n=105). These findings confirm the significant increases in frequency of penetration and frequency of maintained erections reported previously. Sildenafil treatment was well tolerated. The most common adverse events were headache and flushing. In conclusion, sildenafil is a well-tolerated and effective treatment for ED of broad-spectrum etiology in Latin American men.</description><identifier>ISSN: 0955-9930</identifier><identifier>EISSN: 1476-5489</identifier><identifier>DOI: 10.1038/sj.ijir.3900895</identifier><identifier>PMID: 12161765</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Administration, Oral ; Adult ; Aged ; Aged, 80 and over ; Brazil ; Dose-Response Relationship, Drug ; Double-Blind Method ; Erectile dysfunction ; Erectile Dysfunction - drug therapy ; Humans ; Libido - drug effects ; Male ; Mexico ; Middle Aged ; Orgasm - drug effects ; Patient Satisfaction ; Piperazines - administration & dosage ; Piperazines - adverse effects ; Piperazines - therapeutic use ; Purines ; Safety ; Sildenafil Citrate ; Sulfones ; Treatment Outcome ; Vasodilator Agents - administration & dosage ; Vasodilator Agents - adverse effects ; Vasodilator Agents - therapeutic use</subject><ispartof>International journal of impotence research, 2002-08, Vol.14 Suppl 2 (S2), p.S27-S32</ispartof><rights>Copyright Nature Publishing Group Aug 2002</rights><rights>Macmillan Publishers Limited 2002.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-8c327c85e5a5cb7f3fa6d9214197c0691d149e98845c8f9f23c27078eebd641a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12161765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Glina, S</creatorcontrib><creatorcontrib>Bertero, E</creatorcontrib><creatorcontrib>Claro, J</creatorcontrib><creatorcontrib>Damião, R</creatorcontrib><creatorcontrib>Faria, G</creatorcontrib><creatorcontrib>Fregonesi, A</creatorcontrib><creatorcontrib>Jaspersen, J</creatorcontrib><creatorcontrib>Mendoza, A</creatorcontrib><creatorcontrib>Mattos, Jr, D</creatorcontrib><creatorcontrib>Rocha, L C</creatorcontrib><creatorcontrib>Sotomayor, M</creatorcontrib><creatorcontrib>Telöken, C</creatorcontrib><creatorcontrib>Ureta, S</creatorcontrib><creatorcontrib>Zonana, E</creatorcontrib><creatorcontrib>Ugarte, F</creatorcontrib><title>Efficacy and safety of flexible-dose oral sildenafil citrate (Viagra) in the treatment of erectile dysfunction in Brazilian and Mexican men</title><title>International journal of impotence research</title><addtitle>Int J Impot Res</addtitle><description>A 12-week, double-blind, placebo-controlled, multicenter study evaluated the efficacy and safety of flexible-dose sildenafil citrate (Viagra) treatment (25, 50 or 100 mg) in Brazilian and Mexican men with erectile dysfunction (ED) of broad-spectrum etiology. Efficacy was assessed on the basis of responses to the 15-item International Index of Erectile Function (IIEF) questionnaire, completed at baseline and after 12 weeks of treatment. At end point, mean scores for all IIEF domains of sexual function (erectile function, orgasmic function, sexual desire, intercourse satisfaction and overall satisfaction) were significantly (P<0.0001) higher in the sildenafil group (n=109) than in the placebo group (n=105). These findings confirm the significant increases in frequency of penetration and frequency of maintained erections reported previously. Sildenafil treatment was well tolerated. The most common adverse events were headache and flushing. In conclusion, sildenafil is a well-tolerated and effective treatment for ED of broad-spectrum etiology in Latin American men.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brazil</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Erectile dysfunction</subject><subject>Erectile Dysfunction - drug therapy</subject><subject>Humans</subject><subject>Libido - drug effects</subject><subject>Male</subject><subject>Mexico</subject><subject>Middle Aged</subject><subject>Orgasm - drug effects</subject><subject>Patient Satisfaction</subject><subject>Piperazines - administration & dosage</subject><subject>Piperazines - adverse effects</subject><subject>Piperazines - therapeutic use</subject><subject>Purines</subject><subject>Safety</subject><subject>Sildenafil Citrate</subject><subject>Sulfones</subject><subject>Treatment Outcome</subject><subject>Vasodilator Agents - administration & dosage</subject><subject>Vasodilator Agents - adverse effects</subject><subject>Vasodilator Agents - therapeutic use</subject><issn>0955-9930</issn><issn>1476-5489</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kT9PwzAUxC0EoqUwsyELFhjS2nHs2CNU5Y9UxAKskes8g6M0KbYjUb4CX5qUVmJiejf87k56h9ApJWNKmJyEauwq58dMESIV30NDmuUi4ZlU-2hIFOeJUowM0FEIFSFEESoO0YCmVNBc8CH6nlnrjDZrrJsSB20hrnFrsa3h0y1qSMo2AG69rnFwdQmNtq7GxkWvI-DLV6ffvL7CrsHxHXD0oOMSmriJAA8muhpwuQ62a3rdNhvwxusvVzvd_FY-9j2m173rGB1YXQc42d0RermdPU_vk_nT3cP0ep4YxklMpGFpbiQHrrlZ5JZZLUqV0oyq3BChaEkzBUrKjBtplU2ZSXOSS4BFKTKq2QhdbHNXvv3oIMSiajvf9JVFKjLOGKH9c0fo_F-KSpWLLTTZQsa3IXiwxcq7pfbrgpJis1ARqmKzULFbqHec7WK7xRLKP343CfsBOd2N6w</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>Glina, S</creator><creator>Bertero, E</creator><creator>Claro, J</creator><creator>Damião, R</creator><creator>Faria, G</creator><creator>Fregonesi, A</creator><creator>Jaspersen, J</creator><creator>Mendoza, A</creator><creator>Mattos, Jr, D</creator><creator>Rocha, L C</creator><creator>Sotomayor, M</creator><creator>Telöken, C</creator><creator>Ureta, S</creator><creator>Zonana, E</creator><creator>Ugarte, F</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20020801</creationdate><title>Efficacy and safety of flexible-dose oral sildenafil citrate (Viagra) in the treatment of erectile dysfunction in Brazilian and Mexican men</title><author>Glina, S ; 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Efficacy was assessed on the basis of responses to the 15-item International Index of Erectile Function (IIEF) questionnaire, completed at baseline and after 12 weeks of treatment. At end point, mean scores for all IIEF domains of sexual function (erectile function, orgasmic function, sexual desire, intercourse satisfaction and overall satisfaction) were significantly (P<0.0001) higher in the sildenafil group (n=109) than in the placebo group (n=105). These findings confirm the significant increases in frequency of penetration and frequency of maintained erections reported previously. Sildenafil treatment was well tolerated. The most common adverse events were headache and flushing. In conclusion, sildenafil is a well-tolerated and effective treatment for ED of broad-spectrum etiology in Latin American men.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>12161765</pmid><doi>10.1038/sj.ijir.3900895</doi></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Administration, Oral Adult Aged Aged, 80 and over Brazil Dose-Response Relationship, Drug Double-Blind Method Erectile dysfunction Erectile Dysfunction - drug therapy Humans Libido - drug effects Male Mexico Middle Aged Orgasm - drug effects Patient Satisfaction Piperazines - administration & dosage Piperazines - adverse effects Piperazines - therapeutic use Purines Safety Sildenafil Citrate Sulfones Treatment Outcome Vasodilator Agents - administration & dosage Vasodilator Agents - adverse effects Vasodilator Agents - therapeutic use |
| title | Efficacy and safety of flexible-dose oral sildenafil citrate (Viagra) in the treatment of erectile dysfunction in Brazilian and Mexican men |
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