Notch signalling and voltage-gated Na+ channel activity in human prostate cancer cells: independent modulation of in vitro motility

This study tested the possible functional relationship of two signalling mechanisms shown previously to be involved in human prostate cancer (PCa), Notch and voltage-gated sodium channel. Notch1 and Notch2 were differentially expressed in PCa cell lines of varying metastatic potential (LNCaP, PC-3,...

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Veröffentlicht in:	Prostate cancer and prostatic diseases 2006-12, Vol.9 (4), p.399-406
Hauptverfasser:	Scorey, N, Fraser, S P, Patel, P, Pridgeon, C, Dallman, M J, Djamgoz, M B A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Precursor Protein Secretases - antagonists & inhibitors Basic Helix-Loop-Helix Transcription Factors - metabolism Biomedical and Life Sciences Biomedicine Calcium-Binding Proteins - metabolism Cancer Research Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Channel gating Dimethyl Sulfoxide - pharmacology Enzyme Inhibitors - pharmacology Epithelial Cells - drug effects Epithelial Cells - metabolism Homeodomain Proteins - metabolism Humans Intercellular Signaling Peptides and Proteins - metabolism Ion Channel Gating - drug effects Jagged-1 Protein Jagged1 protein Ligands Male Membrane Proteins - metabolism Metastases Metastasis Motility Notch1 protein original-article Poisons - pharmacology Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proto-Oncogene Proteins - metabolism Receptor, Notch1 - metabolism Receptor, Notch2 - metabolism Receptor, Notch3 Receptor, Notch4 Receptors, Notch - drug effects Receptors, Notch - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - drug effects RNA, Messenger - metabolism Serrate-Jagged Proteins Signal Transduction - drug effects Signaling Sodium Sodium channels (voltage-gated) Sodium Channels - drug effects Sodium Channels - metabolism Solvents - pharmacology Tetrodotoxin Tetrodotoxin - pharmacology Transcription Factor HES-1 Tumor Cells, Cultured
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