Isolation of CF cell lines corrected at Δf508-CFTR locus by SFHR-mediated targeting

Cystic fibrosis is the most common inherited disease in the Caucasian population. About 70% of all CF chromosomes carry the ΔF508 mutation, a 3-bp deletion that results in the loss of a phenylalanine at amino acid 508 in the CF transmembrane conductance regulator (CFTR) protein. Direct modification...

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Veröffentlicht in:	Gene therapy 2002-06, Vol.9 (11), p.683-685
Hauptverfasser:	BRUSCIA, E, SANGIUOLO, F, SINIBALDI, P, GONCZ, K. K, NOVELLI, G, GRUENERT, D. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino acids Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Cell lines Chromosome deletion Colonies Cystic fibrosis DNA fingerprinting Epithelial cells Fundamental and applied biological sciences. Psychology Gene deletion Gene therapy Genomics Health. Pharmaceutical industry Hereditary diseases Industrial applications and implications. Economical aspects Insertion Introns Medical sciences Mutation Phenylalanine Polymerase chain reaction Population Respiratory tract RNA-directed DNA polymerase Sequence analysis Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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