Docetaxel and 5-FU enhanced the inhibitory effects of apatinib and ramucirumab on growth and migration of gastric cancer
Gastric cancer (GC) is one of the most common malignant tumors in the world. The clinical benefit of anti-angiogenic strategy as a single drug is limited. Some studies showed that the combination of anti-angiogenic therapy and chemotherapy exhibited synergistic effect and reduced the side effects of...
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| Veröffentlicht in: | Life sciences (1973) 2022-05, Vol.296, p.120439, Article 120439 |
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| container_title | Life sciences (1973) |
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| creator | Wu, Jia-Qi Fan, Ruo-Yue Zhai, Jing Li, Chong-Yong Wei, Ping Shen, Li-Zong He, Ming-Fang Wang, Ping Huang, Xin-En |
| description | Gastric cancer (GC) is one of the most common malignant tumors in the world. The clinical benefit of anti-angiogenic strategy as a single drug is limited. Some studies showed that the combination of anti-angiogenic therapy and chemotherapy exhibited synergistic effect and reduced the side effects of chemotherapy drugs. We investigated the combined effects of these two types of drugs in gastric cancer cells in vitro and in vivo.
cell viability, migration, invasion, and apoptosis were evaluated by CCK-8, wound-healing, transwell, and Annexin V-FITC/PI assay, respectively. In vivo anti-cancer efficacy was tested for the cell proliferation and metastasis in cell line derived tumor xenograft (CDX) model and patient derived tumor xenografted (PDX) model based on Tg (fli-1: EGFP) zebrafish embryos;
In the cell experiments, the combination of the two types of drugs could inhibit the proliferation and metastasis of gastric cancer cells and promote apoptosis through VEGFR-2/AKT/ERK1/2 signal. In the zebrafish CDX (zCDX) model and zebrafish PDX (zPDX) model, the combination of the two treatment also showed a synergistic effect in inhibiting gastric cancer cell metastasis and cell proliferation.
Apatinib/ramucirumab targeted therapy combined with docetaxel or 5-fluorouracil (5-FU) may serve as an effective treatment strategy for patients with advanced gastric cancer. |
| doi_str_mv | 10.1016/j.lfs.2022.120439 |
| format | Article |
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cell viability, migration, invasion, and apoptosis were evaluated by CCK-8, wound-healing, transwell, and Annexin V-FITC/PI assay, respectively. In vivo anti-cancer efficacy was tested for the cell proliferation and metastasis in cell line derived tumor xenograft (CDX) model and patient derived tumor xenografted (PDX) model based on Tg (fli-1: EGFP) zebrafish embryos;
In the cell experiments, the combination of the two types of drugs could inhibit the proliferation and metastasis of gastric cancer cells and promote apoptosis through VEGFR-2/AKT/ERK1/2 signal. In the zebrafish CDX (zCDX) model and zebrafish PDX (zPDX) model, the combination of the two treatment also showed a synergistic effect in inhibiting gastric cancer cell metastasis and cell proliferation.
Apatinib/ramucirumab targeted therapy combined with docetaxel or 5-fluorouracil (5-FU) may serve as an effective treatment strategy for patients with advanced gastric cancer.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2022.120439</identifier><identifier>PMID: 35235851</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>5-Fluorouracil ; AKT protein ; Angiogenesis ; Angiogenesis Inhibitors - administration & dosage ; Angiogenesis Inhibitors - pharmacology ; Animals ; Animals, Genetically Modified ; Annexin V ; Anti-angiogenic therapy ; Antiangiogenics ; Antibodies, Monoclonal, Humanized - administration & dosage ; Anticancer properties ; Antineoplastic Combined Chemotherapy Protocols - pharmacology ; Apoptosis ; Cancer therapies ; Cell growth ; Cell Line, Tumor ; Cell migration ; Cell Movement - drug effects ; Cell proliferation ; Cell Proliferation - drug effects ; Cell viability ; Chemotherapy ; Cholecystokinin ; Combined treatment ; Danio rerio ; Docetaxel - administration & dosage ; Embryo, Nonmammalian ; Embryos ; FLI-1 protein ; Fluorouracil - administration & dosage ; Gastric cancer ; Humans ; In vitro methods and tests ; In vivo methods and tests ; Metastases ; Metastasis ; Patients ; Proto-Oncogene Proteins c-akt - metabolism ; Pyridines - administration & dosage ; Ramucirumab ; Side effects ; Stomach Neoplasms - drug therapy ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; Synergistic effect ; Tumors ; Vascular Endothelial Growth Factor Receptor-2 - metabolism ; Vascular endothelial growth factor receptors ; Wound healing ; Xenograft Model Antitumor Assays ; Xenografts ; Xenotransplantation ; Zebrafish ; Zebrafish - embryology ; Zebrafish - genetics ; zPDX</subject><ispartof>Life sciences (1973), 2022-05, Vol.296, p.120439, Article 120439</ispartof><rights>2022 Elsevier Inc.</rights><rights>Copyright © 2022. Published by Elsevier Inc.</rights><rights>Copyright Elsevier BV May 1, 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-90bb582aadab269ccbafea9698abf7f1092e494551b9fcf80c9f7e216e133df83</citedby><cites>FETCH-LOGICAL-c381t-90bb582aadab269ccbafea9698abf7f1092e494551b9fcf80c9f7e216e133df83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0024320522001394$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35235851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Jia-Qi</creatorcontrib><creatorcontrib>Fan, Ruo-Yue</creatorcontrib><creatorcontrib>Zhai, Jing</creatorcontrib><creatorcontrib>Li, Chong-Yong</creatorcontrib><creatorcontrib>Wei, Ping</creatorcontrib><creatorcontrib>Shen, Li-Zong</creatorcontrib><creatorcontrib>He, Ming-Fang</creatorcontrib><creatorcontrib>Wang, Ping</creatorcontrib><creatorcontrib>Huang, Xin-En</creatorcontrib><title>Docetaxel and 5-FU enhanced the inhibitory effects of apatinib and ramucirumab on growth and migration of gastric cancer</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Gastric cancer (GC) is one of the most common malignant tumors in the world. The clinical benefit of anti-angiogenic strategy as a single drug is limited. Some studies showed that the combination of anti-angiogenic therapy and chemotherapy exhibited synergistic effect and reduced the side effects of chemotherapy drugs. We investigated the combined effects of these two types of drugs in gastric cancer cells in vitro and in vivo.
cell viability, migration, invasion, and apoptosis were evaluated by CCK-8, wound-healing, transwell, and Annexin V-FITC/PI assay, respectively. In vivo anti-cancer efficacy was tested for the cell proliferation and metastasis in cell line derived tumor xenograft (CDX) model and patient derived tumor xenografted (PDX) model based on Tg (fli-1: EGFP) zebrafish embryos;
In the cell experiments, the combination of the two types of drugs could inhibit the proliferation and metastasis of gastric cancer cells and promote apoptosis through VEGFR-2/AKT/ERK1/2 signal. In the zebrafish CDX (zCDX) model and zebrafish PDX (zPDX) model, the combination of the two treatment also showed a synergistic effect in inhibiting gastric cancer cell metastasis and cell proliferation.
Apatinib/ramucirumab targeted therapy combined with docetaxel or 5-fluorouracil (5-FU) may serve as an effective treatment strategy for patients with advanced gastric cancer.</description><subject>5-Fluorouracil</subject><subject>AKT protein</subject><subject>Angiogenesis</subject><subject>Angiogenesis Inhibitors - administration & dosage</subject><subject>Angiogenesis Inhibitors - pharmacology</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Annexin V</subject><subject>Anti-angiogenic therapy</subject><subject>Antiangiogenics</subject><subject>Antibodies, Monoclonal, Humanized - administration & dosage</subject><subject>Anticancer properties</subject><subject>Antineoplastic Combined Chemotherapy Protocols - pharmacology</subject><subject>Apoptosis</subject><subject>Cancer therapies</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell migration</subject><subject>Cell Movement - drug effects</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell viability</subject><subject>Chemotherapy</subject><subject>Cholecystokinin</subject><subject>Combined treatment</subject><subject>Danio rerio</subject><subject>Docetaxel - administration & dosage</subject><subject>Embryo, Nonmammalian</subject><subject>Embryos</subject><subject>FLI-1 protein</subject><subject>Fluorouracil - administration & dosage</subject><subject>Gastric cancer</subject><subject>Humans</subject><subject>In vitro methods and tests</subject><subject>In vivo methods and tests</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Patients</subject><subject>Proto-Oncogene Proteins c-akt - metabolism</subject><subject>Pyridines - administration & dosage</subject><subject>Ramucirumab</subject><subject>Side effects</subject><subject>Stomach Neoplasms - drug therapy</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>Synergistic effect</subject><subject>Tumors</subject><subject>Vascular Endothelial Growth Factor Receptor-2 - metabolism</subject><subject>Vascular endothelial growth factor receptors</subject><subject>Wound healing</subject><subject>Xenograft Model Antitumor Assays</subject><subject>Xenografts</subject><subject>Xenotransplantation</subject><subject>Zebrafish</subject><subject>Zebrafish - embryology</subject><subject>Zebrafish - genetics</subject><subject>zPDX</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1uGyEUhVGUKHbTPEA2FVLX4_IzzAzqqnLqtlKkbJo1AuZiY3kGF5j8vH2wnXSZFdLlO-fqfgjdULKghDbftoudSwtGGFtQRmouz9Ccdq2sSMPpOZoTwuqKMyJm6FNKW0KIEC2_RDMuGBedoHP0fBssZP0MO6zHHotq9YBh3OjRQo_zBrAfN974HOILBufA5oSDw3qvsx-9OYaiHibr4zRog8OI1zE85c3xZ_DrWMAyLJm1Tjl6i-2hPH5GF07vEly_vVfoYfXz7_J3dXf_68_yx11leUdzJYkxomNa99qwRlprtAMtG9lp41pHiWRQy1oIaqSzriNWuhYYbYBy3ruOX6Gvp959DP8mSFltwxTHslKxpq5r3rSMFYqeKBtDShGc2kc_6PiiKFEH12qrimt1cK1Orkvmy1vzZAbo_yfe5Rbg-wmAct-jh6iS9XAw62MRqfrgP6h_BZClkE4</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Wu, Jia-Qi</creator><creator>Fan, Ruo-Yue</creator><creator>Zhai, Jing</creator><creator>Li, Chong-Yong</creator><creator>Wei, Ping</creator><creator>Shen, Li-Zong</creator><creator>He, Ming-Fang</creator><creator>Wang, Ping</creator><creator>Huang, Xin-En</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20220501</creationdate><title>Docetaxel and 5-FU enhanced the inhibitory effects of apatinib and ramucirumab on growth and migration of gastric cancer</title><author>Wu, Jia-Qi ; Fan, Ruo-Yue ; Zhai, Jing ; Li, Chong-Yong ; Wei, Ping ; Shen, Li-Zong ; He, Ming-Fang ; Wang, Ping ; Huang, Xin-En</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-90bb582aadab269ccbafea9698abf7f1092e494551b9fcf80c9f7e216e133df83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>5-Fluorouracil</topic><topic>AKT protein</topic><topic>Angiogenesis</topic><topic>Angiogenesis Inhibitors - administration & dosage</topic><topic>Angiogenesis Inhibitors - pharmacology</topic><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>Annexin V</topic><topic>Anti-angiogenic therapy</topic><topic>Antiangiogenics</topic><topic>Antibodies, Monoclonal, Humanized - administration & dosage</topic><topic>Anticancer properties</topic><topic>Antineoplastic Combined Chemotherapy Protocols - pharmacology</topic><topic>Apoptosis</topic><topic>Cancer therapies</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell migration</topic><topic>Cell Movement - drug effects</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell viability</topic><topic>Chemotherapy</topic><topic>Cholecystokinin</topic><topic>Combined treatment</topic><topic>Danio rerio</topic><topic>Docetaxel - administration & dosage</topic><topic>Embryo, Nonmammalian</topic><topic>Embryos</topic><topic>FLI-1 protein</topic><topic>Fluorouracil - administration & dosage</topic><topic>Gastric cancer</topic><topic>Humans</topic><topic>In vitro methods and tests</topic><topic>In vivo methods and tests</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Patients</topic><topic>Proto-Oncogene Proteins c-akt - metabolism</topic><topic>Pyridines - administration & dosage</topic><topic>Ramucirumab</topic><topic>Side effects</topic><topic>Stomach Neoplasms - drug therapy</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><topic>Synergistic effect</topic><topic>Tumors</topic><topic>Vascular Endothelial Growth Factor Receptor-2 - metabolism</topic><topic>Vascular endothelial growth factor receptors</topic><topic>Wound healing</topic><topic>Xenograft Model Antitumor Assays</topic><topic>Xenografts</topic><topic>Xenotransplantation</topic><topic>Zebrafish</topic><topic>Zebrafish - embryology</topic><topic>Zebrafish - genetics</topic><topic>zPDX</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Jia-Qi</creatorcontrib><creatorcontrib>Fan, Ruo-Yue</creatorcontrib><creatorcontrib>Zhai, Jing</creatorcontrib><creatorcontrib>Li, Chong-Yong</creatorcontrib><creatorcontrib>Wei, Ping</creatorcontrib><creatorcontrib>Shen, Li-Zong</creatorcontrib><creatorcontrib>He, Ming-Fang</creatorcontrib><creatorcontrib>Wang, Ping</creatorcontrib><creatorcontrib>Huang, Xin-En</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Jia-Qi</au><au>Fan, Ruo-Yue</au><au>Zhai, Jing</au><au>Li, Chong-Yong</au><au>Wei, Ping</au><au>Shen, Li-Zong</au><au>He, Ming-Fang</au><au>Wang, Ping</au><au>Huang, Xin-En</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Docetaxel and 5-FU enhanced the inhibitory effects of apatinib and ramucirumab on growth and migration of gastric cancer</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>296</volume><spage>120439</spage><pages>120439-</pages><artnum>120439</artnum><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Gastric cancer (GC) is one of the most common malignant tumors in the world. The clinical benefit of anti-angiogenic strategy as a single drug is limited. Some studies showed that the combination of anti-angiogenic therapy and chemotherapy exhibited synergistic effect and reduced the side effects of chemotherapy drugs. We investigated the combined effects of these two types of drugs in gastric cancer cells in vitro and in vivo.
cell viability, migration, invasion, and apoptosis were evaluated by CCK-8, wound-healing, transwell, and Annexin V-FITC/PI assay, respectively. In vivo anti-cancer efficacy was tested for the cell proliferation and metastasis in cell line derived tumor xenograft (CDX) model and patient derived tumor xenografted (PDX) model based on Tg (fli-1: EGFP) zebrafish embryos;
In the cell experiments, the combination of the two types of drugs could inhibit the proliferation and metastasis of gastric cancer cells and promote apoptosis through VEGFR-2/AKT/ERK1/2 signal. In the zebrafish CDX (zCDX) model and zebrafish PDX (zPDX) model, the combination of the two treatment also showed a synergistic effect in inhibiting gastric cancer cell metastasis and cell proliferation.
Apatinib/ramucirumab targeted therapy combined with docetaxel or 5-fluorouracil (5-FU) may serve as an effective treatment strategy for patients with advanced gastric cancer.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>35235851</pmid><doi>10.1016/j.lfs.2022.120439</doi></addata></record> |
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| subjects | 5-Fluorouracil AKT protein Angiogenesis Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - pharmacology Animals Animals, Genetically Modified Annexin V Anti-angiogenic therapy Antiangiogenics Antibodies, Monoclonal, Humanized - administration & dosage Anticancer properties Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis Cancer therapies Cell growth Cell Line, Tumor Cell migration Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Cell viability Chemotherapy Cholecystokinin Combined treatment Danio rerio Docetaxel - administration & dosage Embryo, Nonmammalian Embryos FLI-1 protein Fluorouracil - administration & dosage Gastric cancer Humans In vitro methods and tests In vivo methods and tests Metastases Metastasis Patients Proto-Oncogene Proteins c-akt - metabolism Pyridines - administration & dosage Ramucirumab Side effects Stomach Neoplasms - drug therapy Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Synergistic effect Tumors Vascular Endothelial Growth Factor Receptor-2 - metabolism Vascular endothelial growth factor receptors Wound healing Xenograft Model Antitumor Assays Xenografts Xenotransplantation Zebrafish Zebrafish - embryology Zebrafish - genetics zPDX |
| title | Docetaxel and 5-FU enhanced the inhibitory effects of apatinib and ramucirumab on growth and migration of gastric cancer |
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