NLRP3 inflammasome is involved in testicular inflammation induced by lipopolysaccharide in mice

Problem Systemic inflammation induced by infection, which is associated with testicular inflammation, predisposes males to subfertility. Recently, the nucleotide‐binding oligomerization domain, leucine‐rich repeat‐, and pyrin domain‐containing 3 (NLRP3) inflammasome was identified as a key mediator...

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Veröffentlicht in:	American journal of reproductive immunology (1989) 2022-04, Vol.87 (4), p.e13527-n/a
Hauptverfasser:	Sano, Michiya, Komiyama, Hiromu, Shinoda, Riina, Ozawa, Ren, Watanabe, Hiroyuki, Karasawa, Tadayoshi, Takahashi, Masafumi, Torii, Yasushi, Iwata, Hisataka, Kuwayama, Takehito, Shirasuna, Koumei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CCL2 Cell culture Chemokines Epididymis Fertility Humans Infectious diseases Infertility Inflammasomes Inflammation Inflammation - chemically induced Interleukin-1beta interleukin‐1β Leukocytes (neutrophilic) Lipopolysaccharides Lipopolysaccharides - pharmacology Male Mice Mice, Inbred C57BL Mice, Knockout Monocyte chemoattractant protein 1 neutrophils NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLRP3 inflammasome Oligomerization Orchitis Pyrin protein Sperm Motility Testes testicular inflammation
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