Vitamin B12 Hydrophobic Derivative Exhibits Bioactivity: Biomedical and Photophysical Study
Vitamin B 12 (cyanocobalamin) and some of its hydrophilic derivatives are used as antidotes and also to treat megaloblastic anemia, nerve myelination disorders, and liver pathology. This work presents results of a comparative experimental study of cyanocobalamin and its derivatives aquacobalamin and...
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| Veröffentlicht in: | BioNanoScience 2022-03, Vol.12 (1), p.74-82 |
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| creator | Gromova, O. A. Maiorova, L. A. Salnikov, D. S. Demidov, V. I. Kalacheva, A. G. Torshin, I. Yu Bogacheva, T. E. Gromov, A. N. Limanova, O. A. Grishina, T. R. Jafari, S. M. Koifman, O.I. |
| description | Vitamin B
12
(cyanocobalamin) and some of its hydrophilic derivatives are used as antidotes and also to treat megaloblastic anemia, nerve myelination disorders, and liver pathology. This work presents results of a comparative experimental study of cyanocobalamin and its derivatives aquacobalamin and heptamethyl ester of cyanoaquacobyrinic acid. In a model of thiosemicarbazide seizures in rats, aquacobalamin contributed to a lengthening of the seizure latency period while cyanocobalamin contributed to a decrease in the seizure latency period and to a decrease in seizures. Histological study of the brain samples showed that all investigated compounds exhibited an antispasmodic effect as well as neuroprotective and myelinating effects. For the first time it was shown that a derivative of vitamin B
12
, which has hydrophobic substituents—heptamethyl ester of cyanoaquacobyrinic acid, also exhibits biological activity and, therefore, is of interest for further research. Analysis of changes in the electronic absorption spectra recorded during the interaction of aquacobalamin with thiosemicarbazide indicated possibility of direct interaction of thiosemicarbazide with aquacobalamin. |
| doi_str_mv | 10.1007/s12668-021-00916-4 |
| format | Article |
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12
(cyanocobalamin) and some of its hydrophilic derivatives are used as antidotes and also to treat megaloblastic anemia, nerve myelination disorders, and liver pathology. This work presents results of a comparative experimental study of cyanocobalamin and its derivatives aquacobalamin and heptamethyl ester of cyanoaquacobyrinic acid. In a model of thiosemicarbazide seizures in rats, aquacobalamin contributed to a lengthening of the seizure latency period while cyanocobalamin contributed to a decrease in the seizure latency period and to a decrease in seizures. Histological study of the brain samples showed that all investigated compounds exhibited an antispasmodic effect as well as neuroprotective and myelinating effects. For the first time it was shown that a derivative of vitamin B
12
, which has hydrophobic substituents—heptamethyl ester of cyanoaquacobyrinic acid, also exhibits biological activity and, therefore, is of interest for further research. Analysis of changes in the electronic absorption spectra recorded during the interaction of aquacobalamin with thiosemicarbazide indicated possibility of direct interaction of thiosemicarbazide with aquacobalamin.</description><identifier>ISSN: 2191-1630</identifier><identifier>EISSN: 2191-1649</identifier><identifier>DOI: 10.1007/s12668-021-00916-4</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Absorption spectra ; Anemia ; Antidotes ; Biological activity ; Biological and Medical Physics ; Biomaterials ; Biophysics ; Circuits and Systems ; Cyanocobalamin ; Engineering ; Hydrophobicity ; Latency ; Liver diseases ; Muscle relaxants ; Myelination ; Nanotechnology ; Neuroprotection ; Parasympathetic nervous system ; Seizures ; Thiosemicarbazides ; Vitamin B12</subject><ispartof>BioNanoScience, 2022-03, Vol.12 (1), p.74-82</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-7ae91a53259c3c3194f62c07441a043ac457bd079b5bf75ac2a5c5be20c82e3</citedby><cites>FETCH-LOGICAL-c319t-7ae91a53259c3c3194f62c07441a043ac457bd079b5bf75ac2a5c5be20c82e3</cites><orcidid>0000-0003-3172-5621</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12668-021-00916-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12668-021-00916-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Gromova, O. A.</creatorcontrib><creatorcontrib>Maiorova, L. A.</creatorcontrib><creatorcontrib>Salnikov, D. S.</creatorcontrib><creatorcontrib>Demidov, V. I.</creatorcontrib><creatorcontrib>Kalacheva, A. G.</creatorcontrib><creatorcontrib>Torshin, I. Yu</creatorcontrib><creatorcontrib>Bogacheva, T. E.</creatorcontrib><creatorcontrib>Gromov, A. N.</creatorcontrib><creatorcontrib>Limanova, O. A.</creatorcontrib><creatorcontrib>Grishina, T. R.</creatorcontrib><creatorcontrib>Jafari, S. M.</creatorcontrib><creatorcontrib>Koifman, O.I.</creatorcontrib><title>Vitamin B12 Hydrophobic Derivative Exhibits Bioactivity: Biomedical and Photophysical Study</title><title>BioNanoScience</title><addtitle>BioNanoSci</addtitle><description>Vitamin B
12
(cyanocobalamin) and some of its hydrophilic derivatives are used as antidotes and also to treat megaloblastic anemia, nerve myelination disorders, and liver pathology. This work presents results of a comparative experimental study of cyanocobalamin and its derivatives aquacobalamin and heptamethyl ester of cyanoaquacobyrinic acid. In a model of thiosemicarbazide seizures in rats, aquacobalamin contributed to a lengthening of the seizure latency period while cyanocobalamin contributed to a decrease in the seizure latency period and to a decrease in seizures. Histological study of the brain samples showed that all investigated compounds exhibited an antispasmodic effect as well as neuroprotective and myelinating effects. For the first time it was shown that a derivative of vitamin B
12
, which has hydrophobic substituents—heptamethyl ester of cyanoaquacobyrinic acid, also exhibits biological activity and, therefore, is of interest for further research. Analysis of changes in the electronic absorption spectra recorded during the interaction of aquacobalamin with thiosemicarbazide indicated possibility of direct interaction of thiosemicarbazide with aquacobalamin.</description><subject>Absorption spectra</subject><subject>Anemia</subject><subject>Antidotes</subject><subject>Biological activity</subject><subject>Biological and Medical Physics</subject><subject>Biomaterials</subject><subject>Biophysics</subject><subject>Circuits and Systems</subject><subject>Cyanocobalamin</subject><subject>Engineering</subject><subject>Hydrophobicity</subject><subject>Latency</subject><subject>Liver diseases</subject><subject>Muscle relaxants</subject><subject>Myelination</subject><subject>Nanotechnology</subject><subject>Neuroprotection</subject><subject>Parasympathetic nervous system</subject><subject>Seizures</subject><subject>Thiosemicarbazides</subject><subject>Vitamin B12</subject><issn>2191-1630</issn><issn>2191-1649</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9UE1LAzEQDaJgqf0DnhY8r-Zz03iztVqhoFDx4iFks1mb0m5qkhb335vtit4cGGbmMe8N8wC4RPAaQchvAsJFMc4hRjmEAhU5PQEDjATKUUHF6W9P4DkYhbCGKTgsyJgMwPubjWprm2yCcDZvK-92K1dand0bbw8q2oPJZl8rW9oYsol1SifIxva2G7amslptMtVU2cvKxcRtwxFZxn3VXoCzWm2CGf3UIVg-zF6n83zx_Pg0vVvkmiARc66MQIoRzIQmHUTrAmvIKUUKUqI0ZbysIBclK2vOlMaKaVYaDPUYGzIEV73qzrvPvQlRrt3eN-mgxAUlKXn6dAhwv6W9C8GbWu683SrfSgRl56LsXZTJRXl0UdJEIj0ppOXmw_g_6X9Y32_xdKw</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Gromova, O. A.</creator><creator>Maiorova, L. A.</creator><creator>Salnikov, D. S.</creator><creator>Demidov, V. I.</creator><creator>Kalacheva, A. G.</creator><creator>Torshin, I. Yu</creator><creator>Bogacheva, T. E.</creator><creator>Gromov, A. N.</creator><creator>Limanova, O. A.</creator><creator>Grishina, T. R.</creator><creator>Jafari, S. M.</creator><creator>Koifman, O.I.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-3172-5621</orcidid></search><sort><creationdate>20220301</creationdate><title>Vitamin B12 Hydrophobic Derivative Exhibits Bioactivity: Biomedical and Photophysical Study</title><author>Gromova, O. A. ; Maiorova, L. A. ; Salnikov, D. S. ; Demidov, V. I. ; Kalacheva, A. G. ; Torshin, I. Yu ; Bogacheva, T. E. ; Gromov, A. N. ; Limanova, O. A. ; Grishina, T. R. ; Jafari, S. M. ; Koifman, O.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-7ae91a53259c3c3194f62c07441a043ac457bd079b5bf75ac2a5c5be20c82e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Absorption spectra</topic><topic>Anemia</topic><topic>Antidotes</topic><topic>Biological activity</topic><topic>Biological and Medical Physics</topic><topic>Biomaterials</topic><topic>Biophysics</topic><topic>Circuits and Systems</topic><topic>Cyanocobalamin</topic><topic>Engineering</topic><topic>Hydrophobicity</topic><topic>Latency</topic><topic>Liver diseases</topic><topic>Muscle relaxants</topic><topic>Myelination</topic><topic>Nanotechnology</topic><topic>Neuroprotection</topic><topic>Parasympathetic nervous system</topic><topic>Seizures</topic><topic>Thiosemicarbazides</topic><topic>Vitamin B12</topic><toplevel>online_resources</toplevel><creatorcontrib>Gromova, O. A.</creatorcontrib><creatorcontrib>Maiorova, L. A.</creatorcontrib><creatorcontrib>Salnikov, D. S.</creatorcontrib><creatorcontrib>Demidov, V. I.</creatorcontrib><creatorcontrib>Kalacheva, A. G.</creatorcontrib><creatorcontrib>Torshin, I. Yu</creatorcontrib><creatorcontrib>Bogacheva, T. E.</creatorcontrib><creatorcontrib>Gromov, A. N.</creatorcontrib><creatorcontrib>Limanova, O. A.</creatorcontrib><creatorcontrib>Grishina, T. R.</creatorcontrib><creatorcontrib>Jafari, S. M.</creatorcontrib><creatorcontrib>Koifman, O.I.</creatorcontrib><collection>CrossRef</collection><jtitle>BioNanoScience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gromova, O. A.</au><au>Maiorova, L. A.</au><au>Salnikov, D. S.</au><au>Demidov, V. I.</au><au>Kalacheva, A. G.</au><au>Torshin, I. Yu</au><au>Bogacheva, T. E.</au><au>Gromov, A. N.</au><au>Limanova, O. A.</au><au>Grishina, T. R.</au><au>Jafari, S. M.</au><au>Koifman, O.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin B12 Hydrophobic Derivative Exhibits Bioactivity: Biomedical and Photophysical Study</atitle><jtitle>BioNanoScience</jtitle><stitle>BioNanoSci</stitle><date>2022-03-01</date><risdate>2022</risdate><volume>12</volume><issue>1</issue><spage>74</spage><epage>82</epage><pages>74-82</pages><issn>2191-1630</issn><eissn>2191-1649</eissn><abstract>Vitamin B
12
(cyanocobalamin) and some of its hydrophilic derivatives are used as antidotes and also to treat megaloblastic anemia, nerve myelination disorders, and liver pathology. This work presents results of a comparative experimental study of cyanocobalamin and its derivatives aquacobalamin and heptamethyl ester of cyanoaquacobyrinic acid. In a model of thiosemicarbazide seizures in rats, aquacobalamin contributed to a lengthening of the seizure latency period while cyanocobalamin contributed to a decrease in the seizure latency period and to a decrease in seizures. Histological study of the brain samples showed that all investigated compounds exhibited an antispasmodic effect as well as neuroprotective and myelinating effects. For the first time it was shown that a derivative of vitamin B
12
, which has hydrophobic substituents—heptamethyl ester of cyanoaquacobyrinic acid, also exhibits biological activity and, therefore, is of interest for further research. Analysis of changes in the electronic absorption spectra recorded during the interaction of aquacobalamin with thiosemicarbazide indicated possibility of direct interaction of thiosemicarbazide with aquacobalamin.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s12668-021-00916-4</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3172-5621</orcidid></addata></record> |
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| subjects | Absorption spectra Anemia Antidotes Biological activity Biological and Medical Physics Biomaterials Biophysics Circuits and Systems Cyanocobalamin Engineering Hydrophobicity Latency Liver diseases Muscle relaxants Myelination Nanotechnology Neuroprotection Parasympathetic nervous system Seizures Thiosemicarbazides Vitamin B12 |
| title | Vitamin B12 Hydrophobic Derivative Exhibits Bioactivity: Biomedical and Photophysical Study |
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