Long-chain alkanolealkyl carboxylic acid-based low-viscosity hydrophobic deep eutectic solvents for one-pot extraction of anthraquinones from Rhei Radix et Rhizoma
Natural long-chain alkanol and alkyl carboxylic acid were used to prepare novel hydrophobic deep eutectic solvents (HDESs). These HDESs are liquid at room temperature and have low viscosity (
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| Veröffentlicht in: | Journal of pharmaceutical analysis 2022-02, Vol.12 (1), p.87-95 |
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| container_title | Journal of pharmaceutical analysis |
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| creator | Huang, Anqi Deng, Wenwen Li, Xiao Zheng, Qutong Wang, Xuanxuan Xiao, Yuxiu |
| description | Natural long-chain alkanol and alkyl carboxylic acid were used to prepare novel hydrophobic deep eutectic solvents (HDESs). These HDESs are liquid at room temperature and have low viscosity ( |
| doi_str_mv | 10.1016/j.jpha.2021.03.002 |
| format | Article |
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These HDESs are liquid at room temperature and have low viscosity (<12.26 mPa·s), low polarity (lower than that of methanol, ChCl-based deep eutectic solvents and other reported HDESs), and low density (<0.928 g/mL). A simple one-pot method based on a novel HDES -water two-phase extraction system was constructed for the extraction of weak-polarity bioactive components, anthraquinones, from Rhei Radix et Rhizoma. This HDES-based new extraction method does not consume hazardous organic solvents and can obtain a total anthraquinone yield of 21.52 mg/g, which is close to that obtained by the Chinese pharmacopoeia method (21.22 mg/g) and considerably higher than those by other reported HDESs-based extraction methods (14.20-20.09 mg/g, p < 0.01). The high extraction yield can be mainly attributed to the severe destruction of the RRR cell walls by the extraction system and the excellent dissolving ability of novel HDESs for anthraquinones.</description><identifier>ISSN: 2095-1779</identifier><identifier>EISSN: 2214-0883</identifier><identifier>DOI: 10.1016/j.jpha.2021.03.002</identifier><language>eng</language><publisher>Xi'an: Xi'an Jiaotong University, Journal of Pharmaceutical Analysis</publisher><subject>Anthraquinone ; Cancer ; Carboxylic acids ; Cell walls ; Fourier transforms ; Hydrophobicity ; NMR ; Nuclear magnetic resonance ; Phytochemicals ; Polarity ; Severe acute respiratory syndrome coronavirus 2 ; Solvents ; Viscosity</subject><ispartof>Journal of pharmaceutical analysis, 2022-02, Vol.12 (1), p.87-95</ispartof><rights>Copyright Xi'an Jiaotong University, Journal of Pharmaceutical Analysis Feb 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27922,27923</link.rule.ids></links><search><creatorcontrib>Huang, Anqi</creatorcontrib><creatorcontrib>Deng, Wenwen</creatorcontrib><creatorcontrib>Li, Xiao</creatorcontrib><creatorcontrib>Zheng, Qutong</creatorcontrib><creatorcontrib>Wang, Xuanxuan</creatorcontrib><creatorcontrib>Xiao, Yuxiu</creatorcontrib><title>Long-chain alkanolealkyl carboxylic acid-based low-viscosity hydrophobic deep eutectic solvents for one-pot extraction of anthraquinones from Rhei Radix et Rhizoma</title><title>Journal of pharmaceutical analysis</title><description>Natural long-chain alkanol and alkyl carboxylic acid were used to prepare novel hydrophobic deep eutectic solvents (HDESs). 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The high extraction yield can be mainly attributed to the severe destruction of the RRR cell walls by the extraction system and the excellent dissolving ability of novel HDESs for anthraquinones.</description><subject>Anthraquinone</subject><subject>Cancer</subject><subject>Carboxylic acids</subject><subject>Cell walls</subject><subject>Fourier transforms</subject><subject>Hydrophobicity</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Phytochemicals</subject><subject>Polarity</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Solvents</subject><subject>Viscosity</subject><issn>2095-1779</issn><issn>2214-0883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNik1OwzAQhS0EEhX0AqxGYu3guL9ZIxALVhX7apJMsIPrSW2nNFyHi-IFB-hIo_eevk-Ih1IVpSrXT33RDwYLrXRZqEWhlL4SM63LpVTb7eI6d1WtZLnZVLdiHmOv8m2U3larmfh9Z_8pG4PWA7ov9Owo5-SgwVDzeXK2AWxsK2uM1ILjb3myseFo0wRmagMPhusstUQD0JioSXlFdifyKULHAdiTHDgBnVPAjNkDd4A-mYDH0frMsxj4ADtDFnbY2jNQysv-8AHvxU2HLtL8P-_E4-vLx_ObHAIfR4pp3_MYfEZ7vV7qta7yLy6z_gDHXWc_</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Huang, Anqi</creator><creator>Deng, Wenwen</creator><creator>Li, Xiao</creator><creator>Zheng, Qutong</creator><creator>Wang, Xuanxuan</creator><creator>Xiao, Yuxiu</creator><general>Xi'an Jiaotong University, Journal of Pharmaceutical Analysis</general><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20220201</creationdate><title>Long-chain alkanolealkyl carboxylic acid-based low-viscosity hydrophobic deep eutectic solvents for one-pot extraction of anthraquinones from Rhei Radix et Rhizoma</title><author>Huang, Anqi ; Deng, Wenwen ; Li, Xiao ; Zheng, Qutong ; Wang, Xuanxuan ; Xiao, Yuxiu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_26426292623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anthraquinone</topic><topic>Cancer</topic><topic>Carboxylic acids</topic><topic>Cell walls</topic><topic>Fourier transforms</topic><topic>Hydrophobicity</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Phytochemicals</topic><topic>Polarity</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Solvents</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Anqi</creatorcontrib><creatorcontrib>Deng, Wenwen</creatorcontrib><creatorcontrib>Li, Xiao</creatorcontrib><creatorcontrib>Zheng, Qutong</creatorcontrib><creatorcontrib>Wang, Xuanxuan</creatorcontrib><creatorcontrib>Xiao, Yuxiu</creatorcontrib><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of pharmaceutical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Anqi</au><au>Deng, Wenwen</au><au>Li, Xiao</au><au>Zheng, Qutong</au><au>Wang, Xuanxuan</au><au>Xiao, Yuxiu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-chain alkanolealkyl carboxylic acid-based low-viscosity hydrophobic deep eutectic solvents for one-pot extraction of anthraquinones from Rhei Radix et Rhizoma</atitle><jtitle>Journal of pharmaceutical analysis</jtitle><date>2022-02-01</date><risdate>2022</risdate><volume>12</volume><issue>1</issue><spage>87</spage><epage>95</epage><pages>87-95</pages><issn>2095-1779</issn><eissn>2214-0883</eissn><abstract>Natural long-chain alkanol and alkyl carboxylic acid were used to prepare novel hydrophobic deep eutectic solvents (HDESs). These HDESs are liquid at room temperature and have low viscosity (<12.26 mPa·s), low polarity (lower than that of methanol, ChCl-based deep eutectic solvents and other reported HDESs), and low density (<0.928 g/mL). A simple one-pot method based on a novel HDES -water two-phase extraction system was constructed for the extraction of weak-polarity bioactive components, anthraquinones, from Rhei Radix et Rhizoma. This HDES-based new extraction method does not consume hazardous organic solvents and can obtain a total anthraquinone yield of 21.52 mg/g, which is close to that obtained by the Chinese pharmacopoeia method (21.22 mg/g) and considerably higher than those by other reported HDESs-based extraction methods (14.20-20.09 mg/g, p < 0.01). The high extraction yield can be mainly attributed to the severe destruction of the RRR cell walls by the extraction system and the excellent dissolving ability of novel HDESs for anthraquinones.</abstract><cop>Xi'an</cop><pub>Xi'an Jiaotong University, Journal of Pharmaceutical Analysis</pub><doi>10.1016/j.jpha.2021.03.002</doi></addata></record> |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Anthraquinone Cancer Carboxylic acids Cell walls Fourier transforms Hydrophobicity NMR Nuclear magnetic resonance Phytochemicals Polarity Severe acute respiratory syndrome coronavirus 2 Solvents Viscosity |
| title | Long-chain alkanolealkyl carboxylic acid-based low-viscosity hydrophobic deep eutectic solvents for one-pot extraction of anthraquinones from Rhei Radix et Rhizoma |
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