Coffee, caffeine and blood pressure : a critical review
We review the published data relating to intake of coffee and caffeine on blood pressure in man. We also refer to studies on the possible mechanisms of actions of these effects of caffeine. The MEDLINE and Current Contents databases were searched from 1966 to April 1999 using the text words 'co...
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| Veröffentlicht in: | European journal of clinical nutrition 1999-11, Vol.53 (11), p.831-839 |
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| container_title | European journal of clinical nutrition |
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| creator | NURMINEN, M.-L NIITTYNEN, L KORPELA, R VAPAATALO, H |
| description | We review the published data relating to intake of coffee and caffeine on blood pressure in man. We also refer to studies on the possible mechanisms of actions of these effects of caffeine.
The MEDLINE and Current Contents databases were searched from 1966 to April 1999 using the text words 'coffee or caffeine' and 'blood pressure or hypertension'. Controlled clinical and epidemiologic studies on the blood pressure effects of coffee or caffeine are reviewed. We also refer to studies on the possible mechanisms of action of these effects of caffeine.
Acute intake of coffee and caffeine increases blood pressure. Caffeine is probably the main active component in coffee. The pressor response is strongest in hypertensive subjects. Some studies with repeated administration of caffeine showed a persistent pressor effect, whereas in others chronic caffeine ingestion did not increase blood pressure. Epidemiologic studies have produced contradictory findings regarding the association between blood pressure and coffee consumption. During regular use tolerance to the cardiovascular responses develops in some people, and therefore no systematic elevation of blood pressure in long-term and in population studies can be shown.
We conclude that regular coffee may be harmful to some hypertension-prone subjects. The hemodynamic effects of chronic coffee and caffeine consumption have not been sufficiently studied. The possible mechanisms of the cardiovascular effects of caffeine include the blocking of adenosine receptors and the inhibition of phosphodiesterases. |
| doi_str_mv | 10.1038/sj.ejcn.1600899 |
| format | Article |
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The MEDLINE and Current Contents databases were searched from 1966 to April 1999 using the text words 'coffee or caffeine' and 'blood pressure or hypertension'. Controlled clinical and epidemiologic studies on the blood pressure effects of coffee or caffeine are reviewed. We also refer to studies on the possible mechanisms of action of these effects of caffeine.
Acute intake of coffee and caffeine increases blood pressure. Caffeine is probably the main active component in coffee. The pressor response is strongest in hypertensive subjects. Some studies with repeated administration of caffeine showed a persistent pressor effect, whereas in others chronic caffeine ingestion did not increase blood pressure. Epidemiologic studies have produced contradictory findings regarding the association between blood pressure and coffee consumption. During regular use tolerance to the cardiovascular responses develops in some people, and therefore no systematic elevation of blood pressure in long-term and in population studies can be shown.
We conclude that regular coffee may be harmful to some hypertension-prone subjects. The hemodynamic effects of chronic coffee and caffeine consumption have not been sufficiently studied. The possible mechanisms of the cardiovascular effects of caffeine include the blocking of adenosine receptors and the inhibition of phosphodiesterases.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/sj.ejcn.1600899</identifier><identifier>PMID: 10556993</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Adenosine ; Adenosine receptors ; Adolescent ; Adult ; Aged ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood pressure ; Blood Pressure - drug effects ; Caffeine ; Caffeine - administration & dosage ; Caffeine - adverse effects ; Cardiology. Vascular system ; Cardiovascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Coffee ; Coffee - adverse effects ; Consumption ; Epidemiology ; Hemodynamics ; Hemodynamics - drug effects ; Humans ; Hypertension ; Hypertension - chemically induced ; Ingestion ; Medical sciences ; MEDLINE ; Middle Aged ; Population studies ; Pressure effects</subject><ispartof>European journal of clinical nutrition, 1999-11, Vol.53 (11), p.831-839</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Nov 1999</rights><rights>Macmillan Publishers Limited 1999.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-450b848d78f96702fd913bd0aad79e9a8ce818be460f95f626910e0b4551815a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1994590$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10556993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NURMINEN, M.-L</creatorcontrib><creatorcontrib>NIITTYNEN, L</creatorcontrib><creatorcontrib>KORPELA, R</creatorcontrib><creatorcontrib>VAPAATALO, H</creatorcontrib><title>Coffee, caffeine and blood pressure : a critical review</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><description>We review the published data relating to intake of coffee and caffeine on blood pressure in man. We also refer to studies on the possible mechanisms of actions of these effects of caffeine.
The MEDLINE and Current Contents databases were searched from 1966 to April 1999 using the text words 'coffee or caffeine' and 'blood pressure or hypertension'. Controlled clinical and epidemiologic studies on the blood pressure effects of coffee or caffeine are reviewed. We also refer to studies on the possible mechanisms of action of these effects of caffeine.
Acute intake of coffee and caffeine increases blood pressure. Caffeine is probably the main active component in coffee. The pressor response is strongest in hypertensive subjects. Some studies with repeated administration of caffeine showed a persistent pressor effect, whereas in others chronic caffeine ingestion did not increase blood pressure. Epidemiologic studies have produced contradictory findings regarding the association between blood pressure and coffee consumption. During regular use tolerance to the cardiovascular responses develops in some people, and therefore no systematic elevation of blood pressure in long-term and in population studies can be shown.
We conclude that regular coffee may be harmful to some hypertension-prone subjects. The hemodynamic effects of chronic coffee and caffeine consumption have not been sufficiently studied. The possible mechanisms of the cardiovascular effects of caffeine include the blocking of adenosine receptors and the inhibition of phosphodiesterases.</description><subject>Adenosine</subject><subject>Adenosine receptors</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Caffeine</subject><subject>Caffeine - administration & dosage</subject><subject>Caffeine - adverse effects</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Coffee</subject><subject>Coffee - adverse effects</subject><subject>Consumption</subject><subject>Epidemiology</subject><subject>Hemodynamics</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - chemically induced</subject><subject>Ingestion</subject><subject>Medical sciences</subject><subject>MEDLINE</subject><subject>Middle Aged</subject><subject>Population studies</subject><subject>Pressure effects</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M9LwzAUwPEgipvTszcJ6tFuL21-epPhLxh40XNI0xdo2dqZbIr_vZ0r6MXTO-TzXuBLyDmDKYNCz1Izxca3UyYBtDEHZMy4kpmQHA7JGIzgWQGgRuQkpQagf1T5MRkxEEIaU4yJmnchIN5Q7_pZt0hdW9Fy2XUVXUdMaRuR3lJHfaw3tXdLGvGjxs9TchTcMuHZMCfk7eH-df6ULV4en-d3i8xzXmwyLqDUXFdKByMV5KEyrCgrcK5SBo3THjXTJXIJwYggc2kYIJRcCKaZcMWEXO3vrmP3vsW0sU23jW3_pc0lz2WuhVK9uvxXMSMl5D9otkc-dilFDHYd65WLX5aB3dW0qbG7mnao2W9cDGe35QqrP36frwfXA3CpbxOia32dfp0xXBgovgHQdXrB</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>NURMINEN, M.-L</creator><creator>NIITTYNEN, L</creator><creator>KORPELA, R</creator><creator>VAPAATALO, H</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>19991101</creationdate><title>Coffee, caffeine and blood pressure : a critical review</title><author>NURMINEN, M.-L ; NIITTYNEN, L ; KORPELA, R ; VAPAATALO, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-450b848d78f96702fd913bd0aad79e9a8ce818be460f95f626910e0b4551815a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adenosine</topic><topic>Adenosine receptors</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Caffeine</topic><topic>Caffeine - administration & dosage</topic><topic>Caffeine - adverse effects</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Coffee</topic><topic>Coffee - adverse effects</topic><topic>Consumption</topic><topic>Epidemiology</topic><topic>Hemodynamics</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - chemically induced</topic><topic>Ingestion</topic><topic>Medical sciences</topic><topic>MEDLINE</topic><topic>Middle Aged</topic><topic>Population studies</topic><topic>Pressure effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NURMINEN, M.-L</creatorcontrib><creatorcontrib>NIITTYNEN, L</creatorcontrib><creatorcontrib>KORPELA, R</creatorcontrib><creatorcontrib>VAPAATALO, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NURMINEN, M.-L</au><au>NIITTYNEN, L</au><au>KORPELA, R</au><au>VAPAATALO, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coffee, caffeine and blood pressure : a critical review</atitle><jtitle>European journal of clinical nutrition</jtitle><addtitle>Eur J Clin Nutr</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>53</volume><issue>11</issue><spage>831</spage><epage>839</epage><pages>831-839</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>We review the published data relating to intake of coffee and caffeine on blood pressure in man. We also refer to studies on the possible mechanisms of actions of these effects of caffeine.
The MEDLINE and Current Contents databases were searched from 1966 to April 1999 using the text words 'coffee or caffeine' and 'blood pressure or hypertension'. Controlled clinical and epidemiologic studies on the blood pressure effects of coffee or caffeine are reviewed. We also refer to studies on the possible mechanisms of action of these effects of caffeine.
Acute intake of coffee and caffeine increases blood pressure. Caffeine is probably the main active component in coffee. The pressor response is strongest in hypertensive subjects. Some studies with repeated administration of caffeine showed a persistent pressor effect, whereas in others chronic caffeine ingestion did not increase blood pressure. Epidemiologic studies have produced contradictory findings regarding the association between blood pressure and coffee consumption. During regular use tolerance to the cardiovascular responses develops in some people, and therefore no systematic elevation of blood pressure in long-term and in population studies can be shown.
We conclude that regular coffee may be harmful to some hypertension-prone subjects. The hemodynamic effects of chronic coffee and caffeine consumption have not been sufficiently studied. The possible mechanisms of the cardiovascular effects of caffeine include the blocking of adenosine receptors and the inhibition of phosphodiesterases.</abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><pmid>10556993</pmid><doi>10.1038/sj.ejcn.1600899</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Nature Journals Online; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Adenosine Adenosine receptors Adolescent Adult Aged Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood pressure Blood Pressure - drug effects Caffeine Caffeine - administration & dosage Caffeine - adverse effects Cardiology. Vascular system Cardiovascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Coffee Coffee - adverse effects Consumption Epidemiology Hemodynamics Hemodynamics - drug effects Humans Hypertension Hypertension - chemically induced Ingestion Medical sciences MEDLINE Middle Aged Population studies Pressure effects |
| title | Coffee, caffeine and blood pressure : a critical review |
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