Distribution of Myeloid and Plasmacytoid Dendritic Cell Subpopulations in Peripheral Blood of Hyperprolactinemic Women
Dendritic cells (DCs) play key roles in regulating the immune response using the specialized function of processing and presenting antigens. Prolactin (PRL), a hormone produced by the pituitary gland, participates in DC maturation and function. The present study was aimed to determine the frequencie...
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| Veröffentlicht in: | Iranian journal of allergy, asthma, and immunology asthma, and immunology, 2021-04, Vol.20 (2), p.198-204 |
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| container_title | Iranian journal of allergy, asthma, and immunology |
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| creator | Nejad, Fatemeh Raeesi Mohammadi, Mohammad Mahdi Sanjari, Mojgan Afshar, Reza Malkpour Jafari, Elham |
| description | Dendritic cells (DCs) play key roles in regulating the immune response using the specialized function of processing and presenting antigens. Prolactin (PRL), a hormone produced by the pituitary gland, participates in DC maturation and function. The present study was aimed to determine the frequencies of peripheral blood DC subpopulations of myeloid DC (MDC) and plasmacytoid DC (PDC) in hyperprolactinemic (HPRL) women compared to normal healthy volunteers.
This study was conducted on 70 women, including 35 HPRL patients and 35 matched healthy controls, whose PRL serum levels were in the normal range (lower than 25 ng/mL). Serum thyroid-stimulating hormone (TSH) levels were measured in both groups as an indicator of normal thyroid function. The electrochemiluminescence immunoassay method was applied to measure the serum levels of TSH and PRL. The frequencies of MDC and PDC in the peripheral blood samples of both groups were determined by flow cytometry.
The mean serum PRL levels in the HPRL patients and healthy individuals were 46.41 +/- 21.96 and 13.75 +/- 11.19, respectively (p |
| doi_str_mv | 10.18502/ijaai.v20i2.6053 |
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This study was conducted on 70 women, including 35 HPRL patients and 35 matched healthy controls, whose PRL serum levels were in the normal range (lower than 25 ng/mL). Serum thyroid-stimulating hormone (TSH) levels were measured in both groups as an indicator of normal thyroid function. The electrochemiluminescence immunoassay method was applied to measure the serum levels of TSH and PRL. The frequencies of MDC and PDC in the peripheral blood samples of both groups were determined by flow cytometry.
The mean serum PRL levels in the HPRL patients and healthy individuals were 46.41 +/- 21.96 and 13.75 +/- 11.19, respectively (p<0.0001); however TSH levels in both groups were similar and within the normal range (0.4-4.5 mIU/mL) (p=0.2). The frequencies of both MDC and PDC subpopulations in the peripheral blood of HPRL patients were significantly lower than they were in the healthy controls. However, the ratio of MDCs/PDCs in HPRL patients was not significantly different between the two groups (p=0.8).
Our study revealed that an increased level of serum PRL may lead to a reduction in the number of MDC and PDC subpopulations. These results could help clarify the complex relationship between the immune system and the neuroendocrine axis and may be of potential use in understanding the pathogenesis of endocrine and immune disorders.</description><identifier>ISSN: 1735-1502</identifier><identifier>EISSN: 1735-5249</identifier><identifier>DOI: 10.18502/ijaai.v20i2.6053</identifier><identifier>PMID: 33904678</identifier><language>eng</language><publisher>TEHRAN: Tehran Univ Medical Sciences</publisher><subject>Allergy ; Antigen processing ; Antigens ; Dendritic cells ; Flow cytometry ; Hyperprolactinemia ; Immunology ; Life Sciences & Biomedicine ; Myeloid ; Peripheral blood ; Pituitary ; Prolactin ; Science & Technology ; Serum levels ; Thyroid ; Thyroid gland ; Thyroid-stimulating hormone</subject><ispartof>Iranian journal of allergy, asthma, and immunology, 2021-04, Vol.20 (2), p.198-204</ispartof><rights>2021. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>1</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000645052000008</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c438t-26dfacc47e94665724e63dbccf49bcb0ce324083484e1140a09b9779390afc743</citedby><cites>FETCH-LOGICAL-c438t-26dfacc47e94665724e63dbccf49bcb0ce324083484e1140a09b9779390afc743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,865,2103,2115,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33904678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nejad, Fatemeh Raeesi</creatorcontrib><creatorcontrib>Mohammadi, Mohammad Mahdi</creatorcontrib><creatorcontrib>Sanjari, Mojgan</creatorcontrib><creatorcontrib>Afshar, Reza Malkpour</creatorcontrib><creatorcontrib>Jafari, Elham</creatorcontrib><title>Distribution of Myeloid and Plasmacytoid Dendritic Cell Subpopulations in Peripheral Blood of Hyperprolactinemic Women</title><title>Iranian journal of allergy, asthma, and immunology</title><addtitle>IRAN J ALLERGY ASTHM</addtitle><addtitle>Iran J Allergy Asthma Immunol</addtitle><description>Dendritic cells (DCs) play key roles in regulating the immune response using the specialized function of processing and presenting antigens. Prolactin (PRL), a hormone produced by the pituitary gland, participates in DC maturation and function. The present study was aimed to determine the frequencies of peripheral blood DC subpopulations of myeloid DC (MDC) and plasmacytoid DC (PDC) in hyperprolactinemic (HPRL) women compared to normal healthy volunteers.
This study was conducted on 70 women, including 35 HPRL patients and 35 matched healthy controls, whose PRL serum levels were in the normal range (lower than 25 ng/mL). Serum thyroid-stimulating hormone (TSH) levels were measured in both groups as an indicator of normal thyroid function. The electrochemiluminescence immunoassay method was applied to measure the serum levels of TSH and PRL. The frequencies of MDC and PDC in the peripheral blood samples of both groups were determined by flow cytometry.
The mean serum PRL levels in the HPRL patients and healthy individuals were 46.41 +/- 21.96 and 13.75 +/- 11.19, respectively (p<0.0001); however TSH levels in both groups were similar and within the normal range (0.4-4.5 mIU/mL) (p=0.2). The frequencies of both MDC and PDC subpopulations in the peripheral blood of HPRL patients were significantly lower than they were in the healthy controls. However, the ratio of MDCs/PDCs in HPRL patients was not significantly different between the two groups (p=0.8).
Our study revealed that an increased level of serum PRL may lead to a reduction in the number of MDC and PDC subpopulations. These results could help clarify the complex relationship between the immune system and the neuroendocrine axis and may be of potential use in understanding the pathogenesis of endocrine and immune disorders.</description><subject>Allergy</subject><subject>Antigen processing</subject><subject>Antigens</subject><subject>Dendritic cells</subject><subject>Flow cytometry</subject><subject>Hyperprolactinemia</subject><subject>Immunology</subject><subject>Life Sciences & Biomedicine</subject><subject>Myeloid</subject><subject>Peripheral blood</subject><subject>Pituitary</subject><subject>Prolactin</subject><subject>Science & Technology</subject><subject>Serum levels</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid-stimulating hormone</subject><issn>1735-1502</issn><issn>1735-5249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkU2L1TAYhYsozjj6A9xIwY0g95rvpkvtOB8w4oCKy5CkbzWXtKlJO3L_vWnv9S5cmU3Cy3MO78kpipcYbbHkiLxzO63d9oEgR7YCcfqoOMcV5RtOWP34-MYZPCuepbRDiIsakafFGaU1YqKS58XDpUtTdGaeXBjK0JWf9uCDa0s9tOW916nXdj8tg0sY2ugmZ8sGvC-_zGYM4-z1IkylG8p7iG78CVH78oMPoV3cbvYjxDEGr-3kBuiz-nvoYXhePOm0T_DieF8U364-fm1uNnefr2-b93cby6icNkS0nbaWVVAzIXhFGAjaGms7VhtrkAVKGJKUSQYYM6RRbeqqqnM83dmK0Yvi9uDbBr1TY3S9jnsVtFPrIMQfSsecyYMCmmVESNNSxjpOjKACdaQyFCpjhM1ebw5eOc-vGdKkepds_gs9QJiTIhzLWmJKZEZf_4PuwhyHnFQRwQ4rL8vhA2VjSClCd1oQI7UWrNaC1VqwWgrOmldH59n00J4UfxvNgDwAv8GELlkHg4UThhASjCNO0HJk46a1vybMw5Slb_9fSv8AsvPD3w</recordid><startdate>20210417</startdate><enddate>20210417</enddate><creator>Nejad, Fatemeh Raeesi</creator><creator>Mohammadi, Mohammad Mahdi</creator><creator>Sanjari, Mojgan</creator><creator>Afshar, Reza Malkpour</creator><creator>Jafari, Elham</creator><general>Tehran Univ Medical Sciences</general><general>Tehran University of Medical Sciences</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20210417</creationdate><title>Distribution of Myeloid and Plasmacytoid Dendritic Cell Subpopulations in Peripheral Blood of Hyperprolactinemic Women</title><author>Nejad, Fatemeh Raeesi ; 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Prolactin (PRL), a hormone produced by the pituitary gland, participates in DC maturation and function. The present study was aimed to determine the frequencies of peripheral blood DC subpopulations of myeloid DC (MDC) and plasmacytoid DC (PDC) in hyperprolactinemic (HPRL) women compared to normal healthy volunteers.
This study was conducted on 70 women, including 35 HPRL patients and 35 matched healthy controls, whose PRL serum levels were in the normal range (lower than 25 ng/mL). Serum thyroid-stimulating hormone (TSH) levels were measured in both groups as an indicator of normal thyroid function. The electrochemiluminescence immunoassay method was applied to measure the serum levels of TSH and PRL. The frequencies of MDC and PDC in the peripheral blood samples of both groups were determined by flow cytometry.
The mean serum PRL levels in the HPRL patients and healthy individuals were 46.41 +/- 21.96 and 13.75 +/- 11.19, respectively (p<0.0001); however TSH levels in both groups were similar and within the normal range (0.4-4.5 mIU/mL) (p=0.2). The frequencies of both MDC and PDC subpopulations in the peripheral blood of HPRL patients were significantly lower than they were in the healthy controls. However, the ratio of MDCs/PDCs in HPRL patients was not significantly different between the two groups (p=0.8).
Our study revealed that an increased level of serum PRL may lead to a reduction in the number of MDC and PDC subpopulations. These results could help clarify the complex relationship between the immune system and the neuroendocrine axis and may be of potential use in understanding the pathogenesis of endocrine and immune disorders.</abstract><cop>TEHRAN</cop><pub>Tehran Univ Medical Sciences</pub><pmid>33904678</pmid><doi>10.18502/ijaai.v20i2.6053</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Allergy Antigen processing Antigens Dendritic cells Flow cytometry Hyperprolactinemia Immunology Life Sciences & Biomedicine Myeloid Peripheral blood Pituitary Prolactin Science & Technology Serum levels Thyroid Thyroid gland Thyroid-stimulating hormone |
| title | Distribution of Myeloid and Plasmacytoid Dendritic Cell Subpopulations in Peripheral Blood of Hyperprolactinemic Women |
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