Safety and potential efficacy of low-dose methotrexate for treatment of chronic graft-versus-host disease

Low-dose methotrexate (MTX) is widely used in autoimmune diseases because of its anti-inflammatory activity. We report here the results of a retrospective study to review the outcomes of low-dose MTX used for treatment of refractory chronic graft-versus-host disease GVHD, with the goal of reducing t...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2005-08, Vol.36 (4), p.337-341
Hauptverfasser:	Giaccone, L, Martin, P, Carpenter, P, Moravec, C, Hooper, H, Funke, V A M, Storb, R, Flowers, M E D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anti-inflammatory agents Autoimmune diseases Biological and medical sciences Blood transfusion Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Cell Biology Chronic Disease Clinical trials Complications and side effects Diagnosis Disease control Dosage and administration Drug Evaluation Drug therapy Drug Therapy, Combination Fasciitis Female Graft versus host disease Graft versus host reaction Graft vs Host Disease - drug therapy Graft vs Host Disease - pathology Growth factors Health services Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Humans Inflammation Internal Medicine Male Medical sciences Medicine Medicine & Public Health Methotrexate Methotrexate - administration & dosage Methotrexate - toxicity Middle Aged original-article Patient outcomes Patients Prednisone Prednisone - administration & dosage Public Health Reagents Retrospective Studies Risk factors Salvage Therapy Scleroderma Stem cell transplantation Stem Cells Toxicity Transfusion Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Treatment Outcome
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