Successful treatment of severe hemorrhagic cystitis with cystectomy following matched donor allogeneic hematopoietic cell transplantation
We report a case of severe hemorrhagic cystitis complicating high-dose cyclophosphamide (CY), total body irradiation and allogeneic hematopoietic stem cell transplantation (HSCT). Supportive care with i.v. hydration, platelet transfusions, continuous bladder irrigation and aluminum irrigation of the...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2000-10, Vol.26 (8), p.899-901 |
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| container_title | Bone marrow transplantation (Basingstoke) |
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| creator | KOC, S HAGGLUND, H IRETON, R. C PEREZ-SIMON, J. A COLLINS, S. J APPELBAUM, F. R |
| description | We report a case of severe hemorrhagic cystitis complicating high-dose cyclophosphamide (CY), total body irradiation and allogeneic hematopoietic stem cell transplantation (HSCT). Supportive care with i.v. hydration, platelet transfusions, continuous bladder irrigation and aluminum irrigation of the bladder was ineffective and the patient developed multiple complications from hemorrhagic cystitis. His condition became critical with persistent bleeding, pulmonary edema and acute renal failure. These problems resolved following successful simple cystectomy and ileal conduit. The patient did not develop any acute or chronic complications following surgery. He is alive with a good quality of life and in third remission after receiving salvage chemotherapy 14 months after his transplantation. |
| doi_str_mv | 10.1038/sj.bmt.1702611 |
| format | Article |
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C ; PEREZ-SIMON, J. A ; COLLINS, S. J ; APPELBAUM, F. R</creator><creatorcontrib>KOC, S ; HAGGLUND, H ; IRETON, R. C ; PEREZ-SIMON, J. A ; COLLINS, S. J ; APPELBAUM, F. R</creatorcontrib><description>We report a case of severe hemorrhagic cystitis complicating high-dose cyclophosphamide (CY), total body irradiation and allogeneic hematopoietic stem cell transplantation (HSCT). Supportive care with i.v. hydration, platelet transfusions, continuous bladder irrigation and aluminum irrigation of the bladder was ineffective and the patient developed multiple complications from hemorrhagic cystitis. His condition became critical with persistent bleeding, pulmonary edema and acute renal failure. These problems resolved following successful simple cystectomy and ileal conduit. The patient did not develop any acute or chronic complications following surgery. He is alive with a good quality of life and in third remission after receiving salvage chemotherapy 14 months after his transplantation.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/sj.bmt.1702611</identifier><identifier>PMID: 11081392</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Aluminum ; Biological and medical sciences ; Bladder ; Bone marrow ; Bone marrow transplantation ; Case reports ; Chemotherapy ; Complications ; Cyclophosphamide ; Cyclophosphamide - adverse effects ; Cystectomy ; Cystitis ; Cystitis - etiology ; Cystitis - surgery ; Drug toxicity and drugs side effects treatment ; Edema ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic stem cells ; Hemorrhage ; Hemorrhage - surgery ; Hemorrhagic cystitis ; Humans ; Irradiation ; Irrigation ; Male ; Medical sciences ; Middle Aged ; Patients ; Pharmacology. Drug treatments ; Quality of life ; Radiation ; Remission ; Renal failure ; Stem cell transplantation ; Stem cells ; Toxicity: urogenital system ; Transplantation ; Transplantation, Homologous</subject><ispartof>Bone marrow transplantation (Basingstoke), 2000-10, Vol.26 (8), p.899-901</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Oct 2000</rights><rights>Macmillan Publishers Limited 2000.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-a5811065aaae576641a399980ce1b0bc44e92c15f866b8d086e3fc5bfb851b803</citedby><cites>FETCH-LOGICAL-c415t-a5811065aaae576641a399980ce1b0bc44e92c15f866b8d086e3fc5bfb851b803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1535988$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11081392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOC, S</creatorcontrib><creatorcontrib>HAGGLUND, H</creatorcontrib><creatorcontrib>IRETON, R. C</creatorcontrib><creatorcontrib>PEREZ-SIMON, J. A</creatorcontrib><creatorcontrib>COLLINS, S. J</creatorcontrib><creatorcontrib>APPELBAUM, F. R</creatorcontrib><title>Successful treatment of severe hemorrhagic cystitis with cystectomy following matched donor allogeneic hematopoietic cell transplantation</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><description>We report a case of severe hemorrhagic cystitis complicating high-dose cyclophosphamide (CY), total body irradiation and allogeneic hematopoietic stem cell transplantation (HSCT). Supportive care with i.v. hydration, platelet transfusions, continuous bladder irrigation and aluminum irrigation of the bladder was ineffective and the patient developed multiple complications from hemorrhagic cystitis. His condition became critical with persistent bleeding, pulmonary edema and acute renal failure. These problems resolved following successful simple cystectomy and ileal conduit. The patient did not develop any acute or chronic complications following surgery. He is alive with a good quality of life and in third remission after receiving salvage chemotherapy 14 months after his transplantation.</description><subject>Aluminum</subject><subject>Biological and medical sciences</subject><subject>Bladder</subject><subject>Bone marrow</subject><subject>Bone marrow transplantation</subject><subject>Case reports</subject><subject>Chemotherapy</subject><subject>Complications</subject><subject>Cyclophosphamide</subject><subject>Cyclophosphamide - adverse effects</subject><subject>Cystectomy</subject><subject>Cystitis</subject><subject>Cystitis - etiology</subject><subject>Cystitis - surgery</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Edema</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic stem cells</subject><subject>Hemorrhage</subject><subject>Hemorrhage - surgery</subject><subject>Hemorrhagic cystitis</subject><subject>Humans</subject><subject>Irradiation</subject><subject>Irrigation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Pharmacology. Drug treatments</subject><subject>Quality of life</subject><subject>Radiation</subject><subject>Remission</subject><subject>Renal failure</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Toxicity: urogenital system</subject><subject>Transplantation</subject><subject>Transplantation, Homologous</subject><issn>0268-3369</issn><issn>1476-5365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1v2zAMhoWhw5p1u-44CN2uTkXrI_KxKNauQIEe2p0NWaESBbaVSnKL_IT96yqrgZ7GC0Hi4UuCLyHfgC2BcX2RdstuyEtYsVoBfCALECtVSa7kCVmUnq44V80p-ZzSjjEQgslP5BSAaeBNvSB_HyZrMSU39TRHNHnAMdPgaMJnjEi3OIQYt2bjLbWHlH32ib74vP1Xoc1hOFAX-j68-HFDB5PtFtd0HcYQqSntDY5YZouOyWEfPOajEvbHdWZM-96M2WQfxi_kozN9wq9zPiN_rn89Xv2u7u5vbq8u7yorQObKSF2uV9IYg3KllADDm6bRzCJ0rLNCYFNbkE4r1ek10wq5s7JznZbQacbPyI833X0MTxOm3O7CFMeysq2VqEvIWhbq_L8UKLWqpYACLd8gG0NKEV27j34w8dACa4_2tGnXFnva2Z4y8H1WnboB1-_47EcBfs6ASdb0rrzI-vTOSS4brfkrRVmb8g</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>KOC, S</creator><creator>HAGGLUND, H</creator><creator>IRETON, R. 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Supportive care with i.v. hydration, platelet transfusions, continuous bladder irrigation and aluminum irrigation of the bladder was ineffective and the patient developed multiple complications from hemorrhagic cystitis. His condition became critical with persistent bleeding, pulmonary edema and acute renal failure. These problems resolved following successful simple cystectomy and ileal conduit. The patient did not develop any acute or chronic complications following surgery. He is alive with a good quality of life and in third remission after receiving salvage chemotherapy 14 months after his transplantation.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>11081392</pmid><doi>10.1038/sj.bmt.1702611</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Bone marrow transplantation (Basingstoke), 2000-10, Vol.26 (8), p.899-901 |
| issn | 0268-3369 1476-5365 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aluminum Biological and medical sciences Bladder Bone marrow Bone marrow transplantation Case reports Chemotherapy Complications Cyclophosphamide Cyclophosphamide - adverse effects Cystectomy Cystitis Cystitis - etiology Cystitis - surgery Drug toxicity and drugs side effects treatment Edema Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Hemorrhage Hemorrhage - surgery Hemorrhagic cystitis Humans Irradiation Irrigation Male Medical sciences Middle Aged Patients Pharmacology. Drug treatments Quality of life Radiation Remission Renal failure Stem cell transplantation Stem cells Toxicity: urogenital system Transplantation Transplantation, Homologous |
| title | Successful treatment of severe hemorrhagic cystitis with cystectomy following matched donor allogeneic hematopoietic cell transplantation |
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