Repetitive high-dose therapy with cyclophosphamide, thiotepa and docetaxel with peripheral blood progenitor cell and filgrastim support for metastatic and locally advanced breast cancer : results of a phase I study

This phase I study was designed to determine the optimal dosages of a novel repetitive high-dose therapy regimen for patients with metastatic breast cancer (MBC). The planned treatment was three cycles of high-dose cyclophosphamide, thiotepa and docetaxel delivered every 35 days with progressive dos...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2000-11, Vol.26 (9), p.955-961
Hauptverfasser:	PRINCE, H. M, RISCHIN, D, JUNEJA, S, WOLF, M, JANUSZEWICZ, E. H, RICHARDSON, G, SCARLETT, J, BRIGGS, P, TONER, G. C, SEYMOUR, J. F, BLAKEY, D, GATES, P, EERHARD, S, CHAPPLE, P, QUINN, M, BRETTELL, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Blood Bone marrow Bone marrow transplantation Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - therapy Cells (biology) Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Cyclophosphamide Cyclophosphamide - administration & dosage Cyclophosphamide - adverse effects Diarrhea Diarrhea - etiology Disease Progression Female Filgrastim Granulocyte Colony-Stimulating Factor - therapeutic use Hematopoietic Stem Cell Transplantation - adverse effects Hemopoiesis Humans Lung Diseases, Interstitial - etiology Medical sciences Metastases Metastasis Middle Aged Mucositis Neoplasm Metastasis Neutropenia - etiology Paclitaxel - administration & dosage Paclitaxel - adverse effects Paclitaxel - analogs & derivatives Patients Peripheral blood Pharmacology. Drug treatments Pneumonitis Positron emission Progenitor cells Recombinant Proteins Remission Remission Induction Stem cell transplantation Stomatitis - etiology Survival Survival Analysis Taxoids Thiotepa - administration & dosage Thiotepa - adverse effects Thrombocytopenia - etiology Tomography Toxicity Transplantation Transplantation Conditioning - adverse effects
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