Melphalan plus total body irradiation (MEL-TBI) or cyclophosphamide (MEL-CY) as a conditioning regimen with second autotransplant in responding patients with myeloma is inferior compared to historical controls receiving tandem transplants with melphalan alone

The role of more intense conditioning for second transplant was evaluated in myeloma patients achieving at least partial remission (PR) after first transplant with melphalan at 200 mg/m2. Forty-three patients received more intensive conditioning for the second transplant. Nineteen patients received...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2000-03, Vol.25 (5), p.483-487
Hauptverfasser:	DESIKAN, K. R, TRICOT, G, ANAISSIE, E, BARLOGIE, B, MUNSHI, N, DHODAPKAR, M, FASSAS, A, SIEGEL, D, VESOLE, D. H, JAGANNATH, S, SINGHAL, S, MEHTA, J, SPOON, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens, CD34 - metabolism Antineoplastic agents Antineoplastic Agents, Alkylating - therapeutic use Antineoplastic Agents, Alkylating - toxicity beta 2-Microglobulin - blood Biological and medical sciences Bone marrow Bone marrow transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Cohort Studies Combined Modality Therapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Conditioning Cyclophosphamide Cyclophosphamide - administration & dosage Cyclophosphamide - toxicity Disease-Free Survival Engraftment Evaluation Studies as Topic Fever - chemically induced Graft Survival - drug effects Humans Irradiation Lymphocyte Count Lymphocytes Medical sciences Melphalan Melphalan - administration & dosage Melphalan - toxicity Multiple myeloma Multiple Myeloma - therapy Myeloma Patients Pharmacology. Drug treatments Pneumonia - chemically induced Prognosis Radiation Recovery Remission Sepsis - chemically induced Stem cell transplantation Stomatitis - chemically induced Survival Survival Rate Toxicity Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation Conditioning - adverse effects Transplantation, Autologous - adverse effects Transplants Transplants & implants Whole-Body Irradiation
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