Erratum: Case Report: Acute graft-versus-host disease after bone marrow transplantation with a single HLA-DPB11001 mismatch: involvement of different TCRBV subsets

HLA-DP incompatibility is not considered as an exclusion criterion for bone marrow donors, because such incompatibility was not shown to affect significantly the risk for acute graft-versus-host disease (GVHD). In line with this clinical observation, it was proposed that in the context of bone marro...

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Veröffentlicht in:Bone marrow transplantation (Basingstoke) 1999-06, Vol.23 (12), p.1327-1328
Hauptverfasser: Gaschet, J, Gallot, G, Ibisch, C, Lim, A, Even, J, Vivien, R, Hallet, MM, Milpied, N, Vié, H
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Sprache:eng
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Zusammenfassung:HLA-DP incompatibility is not considered as an exclusion criterion for bone marrow donors, because such incompatibility was not shown to affect significantly the risk for acute graft-versus-host disease (GVHD). In line with this clinical observation, it was proposed that in the context of bone marrow transplantation, HLA-DP determinants did not function as transplantation antigens in the same way as HLA-A, -B or -DR. In contrast to the above conclusion, we recently demonstrated the presence of HLA-DPB1*0501 specific T cell clones in a skin biopsy of a patient who developed aGVHD after receiving a bone marrow transplant (BMT) in which the only mismatched allele in the GVHD direction was HLA-DPB1*0501. At that time, this case was unique and occurred in a relatively uncommon graft setting where the patient received purified CD34+ BM cells from an unrelated donor. In the present study, we analyzed the immunological events associated with an aGVHD which occurred in the context of a ‘regular’ allogeneic BMT involving a single HLA-DPB1*1001 mismatch between donor and recipient in the GVHD direction. To this end, we analyzed several amplified T cell subsets present within a T cell line derived from a skin biopsy performed at the onset of GVHD.
ISSN:0268-3369
1476-5365
DOI:10.1038/sj.bmt.1701809