Myeloablative intensified conditioning regimen with in vivo T-cell depletion (ATG) followed by allografting in patients with advanced multiple myeloma. A phase I/II study of the German Study-group Multiple Myeloma (DSMM): Myeloma

We investigated toxicity and efficacy of in vivo T-cell depletion with anti-thymocyte globulin (ATG) as part of an intensified myeloablative conditioning regimen followed by allogeneic stem cell transplantation in patients with advanced multiple myeloma. The conditioning regimen consisted of modifie...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2003-06, Vol.31 (11), p.973-979
Hauptverfasser:	Kröger, Nicolaus, Einsele, Hermann, Wolff, Daniel, Casper, Jochen, Freund, Mathias, Derigs, Günter, Wandt, Hannes, Schäfer-Eckart, K, Wittkowsky, Georg, Schmitz, Norbert, Krüger, William, Zabelina, Tatjana, Renges, Helmut, Ayuk, Francis, Krüll, Andreas, Zander, Axel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Antilymphocyte Serum - adverse effects Antilymphocyte Serum - therapeutic use Antithymocyte globulin Biocompatibility Busulfan Busulfan - therapeutic use Cancer Care and treatment Cell Biology Chronic Disease Conditioning Cyclophosphamide Cyclophosphamide - therapeutic use Depletion Disease-Free Survival Dosage and administration Female Follow-Up Studies Globulins Graft versus host disease Graft versus host reaction Graft vs Host Disease - classification Graft vs Host Disease - epidemiology Graft vs Host Disease - prevention & control Hematology Homografts Humans Immunosuppressive Agents - therapeutic use In vivo methods and tests Internal Medicine Irradiation Lymphocyte Depletion Lymphocytes T Male Medicine Medicine & Public Health Middle Aged Multiple myeloma Multiple Myeloma - pathology Multiple Myeloma - therapy Neoplasm Staging original-article Patient outcomes Patients Physiological aspects Public Health Radiation therapy Relapse Remission Stem cell transplantation Stem Cells Survival Survival Rate T cells T-Lymphocytes - immunology Thymocytes Time Factors Toxicity Transplantation Transplantation Conditioning - adverse effects Transplantation Conditioning - methods Transplantation, Homologous - adverse effects Transplantation, Homologous - mortality Transplants & implants Whole-Body Irradiation
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