A phase I-II study of high-dose melphalan, mitoxantrone and carboplatin with peripheral blood stem cell support in patients with advanced ovarian or breast carcinoma

The purpose of this study was to develop a high-dose chemotherapy (HDC) and peripheral blood stem cell (PBSC) regimen for treatment of patients with ovarian carcinoma that could be administered in an outpatient setting. Fourteen patients with advanced ovarian (n = 9) or breast (n = 5) carcinoma, who...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 1997-11, Vol.20 (10), p.847-853
Hauptverfasser:	WEAVER, C. H, GRECO, F. A, HAINSWORTH, J. D, ZHEN, B, BALDWIN, P, WITTLIN, F, LEWIS, M, WEST, W. H, SCHWARTZBERG, L, BUCKNER, C. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Blood Bone Marrow Diseases - chemically induced Bone Marrow Diseases - therapy Breast cancer Breast carcinoma Breast Neoplasms - drug therapy Breast Neoplasms - pathology Breast Neoplasms - surgery Cancer Carboplatin Carboplatin - administration & dosage Carboplatin - adverse effects Carcinoma - drug therapy Carcinoma - pathology Cerebral Hemorrhage - chemically induced Chemotherapy Combined Modality Therapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Disease-Free Survival Fatalities Female Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Humans Life Tables Lung Diseases, Interstitial - chemically induced Medical sciences Melphalan Melphalan - administration & dosage Melphalan - adverse effects Middle Aged Mitoxantrone Mitoxantrone - administration & dosage Mitoxantrone - adverse effects Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery Patients Peripheral blood Pharmacology. Drug treatments Platinum Renal Insufficiency - chemically induced Salvage Therapy Stem cell transplantation Stem cells Toxicity Treatment Outcome
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