The cytotoxicity of mafosfamide on G-CSF mobilized hematopoietic progenitors is reduced by SH groups of albumin - implications for further purging strategies

The efficacy of mafosfamide purging depends on factors like incubation time, drug and erythrocyte concentration. To determine the influence of protein-bound SH groups in the incubation medium, the cytotoxicity of mafosfamide on G-CSF mobilized CD34+/- cells was evaluated by short-term culture assays...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 1999, Vol.23 (2), p.157-161
Hauptverfasser:	SCHLENKE, P, KISRO, J, DEEKEN, M, ZAJAC, S, KLICH, S, WAGNER, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumin Albumins Albumins - metabolism Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens, CD34 - blood Area Under Curve Biological and medical sciences Bone marrow Bone Marrow Purging - methods Bone marrow, stem cells transplantation. Graft versus host reaction CD34 antigen Cell culture Cells, Cultured - metabolism Colony-Forming Units Assay Cyclophosphamide - analogs & derivatives Cyclophosphamide - toxicity Cytotoxicity Degeneration DNA polymerase DNA-directed DNA polymerase Drug toxicity and drugs side effects treatment Erythrocytes Exonuclease Granulocyte colony-stimulating factor Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - immunology Hemopoiesis Humans Medical sciences Middle Aged Pharmacology. Drug treatments Progenitor cells Purging Regression analysis Stem cell transplantation Time Factors Toxicity Toxicity: blood Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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