Weight gain related to treatment with atypical antipsychotics is due to activation of PKC-β

Atypical antipsychotics (APDs) are currently used in clinical practice for a variety of mental disorders such as schizophrenia, bipolar disorder and severe behavioral disturbances. A well-known disadvantage of using these compounds is a propensity for weight gain, resulting frequently in obesity. Th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The pharmacogenomics journal 2010-10, Vol.10 (5), p.408-417
Hauptverfasser:	Pavan, C, Vindigni, V, Michelotto, L, Rimessi, A, Abatangelo, G, Cortivo, R, Pinton, P, Zavan, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - cytology Adipocytes - drug effects Adipocytes - enzymology Adipogenesis - drug effects Adipogenesis - genetics Animals Animals, Newborn Antipsychotic Agents - adverse effects Antipsychotic drugs Antipsychotics Biomedical and Life Sciences Biomedicine Bipolar disorder Cell culture Cell Culture Techniques Cell Differentiation - drug effects Cell proliferation Cell Proliferation - drug effects Cells, Cultured Drug development Enzyme Activation Gene Expression Gene Expression - drug effects Gene Silencing - drug effects Genetic aspects Health aspects Human Genetics Kinases Mental disorders Oncology original-article Pharmacogenetics Pharmacotherapy Physiological aspects Protein kinase C Protein Kinase C - antagonists & inhibitors Protein Kinase C - genetics Protein Kinase C - metabolism Protein Kinase C beta Protein kinases Psychopharmacology Psychotropic drugs Rats RNA, Small Interfering - genetics RNA, Small Interfering - pharmacology Schizophrenia Stem cell transplantation Stem cells Stem Cells - cytology Stem Cells - drug effects Stem Cells - enzymology Weight Gain - drug effects Weight Gain - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!