The error-prone DNA polymerase ι provides quantitative resistance to lung tumorigenesis and mutagenesis in mice

Opposite undamaged nucleotide T, DNA polymerase ι (Polι) preferentially incorporates G rather than A, violating the Watson–Crick rule. Although the actual biological role of Polι remains enigmatic, we have identified its coding gene as a candidate for pulmonary adenoma resistance 2 ( Par2 ), a mouse...

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