Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo

Δ 9 -Tetrahydrocannabinol (THC) is the primary cannabinoid of marijuana and has been shown to either potentiate or inhibit tumor growth, depending on the type of cancer and its pathogenesis. Little is known about the activity of cannabinoids like THC on epidermal growth factor receptor-overexpressin...

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Veröffentlicht in:	Oncogene 2008-01, Vol.27 (3), p.339-346
Hauptverfasser:	Preet, A, Ganju, R K, Groopman, J E
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Apoptosis Biological and medical sciences Cannabinoid CB1 receptors Cannabinoid CB2 receptors Cannabinoids Cannabis Cell Biology Cell migration Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chemotaxis Chemotherapy Epidermal growth factor Extracellular signal-regulated kinase Fibroblast growth factor 2 Focal adhesion kinase Fundamental and applied biological sciences. Psychology Human Genetics Immunodeficiency Internal Medicine Lung cancer Medical sciences Medicine Medicine & Public Health Metastases Metastasis Molecular and cellular biology Non-small cell lung carcinoma Oncology original-article Phosphorylation Pneumology Small cell lung carcinoma Tetrahydrocannabinol THC Tumor cell lines Tumors Tumors of the respiratory system and mediastinum Tyrosine
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