The role of the transcription factor AP-1 in colitis-associated and β-catenin-dependent intestinal tumorigenesis in mice

Chronic inflammation is an important cancer risk factor but the molecular pathways linking inflammation and cancer are incompletely understood. The transcription factor c-Jun/AP-1 (activator protein 1) is involved in inflammatory responses and tumorigenesis and has been proposed as an essential medi...

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Veröffentlicht in:	Oncogene 2008-10, Vol.27 (47), p.6102-6109
Hauptverfasser:	Hasselblatt, P, Gresh, L, Kudo, H, Guinea-Viniegra, J, Wagner, E F
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator protein 1 Animal models Animals Apoptosis Azoxymethane - toxicity beta Catenin - physiology c-Fos protein c-Jun protein Cancer Cell Biology Cell proliferation Colitis Colitis - complications Colon cancer Colonic Neoplasms - etiology Colorectal cancer Complications and side effects DNA binding proteins Epithelium Fra1 protein Genes, APC Genetic aspects Human Genetics Inflammation Inflammatory bowel disease Internal Medicine Intestinal Mucosa - chemistry JunB protein Medicine Medicine & Public Health Mice Myeloid cells Oncology original-article Physiological aspects Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-jun - analysis Proto-Oncogene Proteins c-jun - physiology Risk factors Signal Transduction Small intestine Transcription Factor AP-1 - physiology Transcription factors Tumorigenesis Tumors β-Catenin
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