p38α and p38δ mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells

Recent studies indicate that the specificity of p38 mitogen-activated protein kinase (MAPK)-mediated cellular stress responses is determined by the expression pattern of the distinct p38 isoforms. Here, we have analysed the function of distinct p38 isoforms in the growth and invasion of head and nec...

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Veröffentlicht in:	Oncogene 2007-08, Vol.26 (36), p.5267-5279
Hauptverfasser:	Junttila, M R, Ala-aho, R, Jokilehto, T, Peltonen, J, Kallajoki, M, Grenman, R, Jaakkola, P, Westermarck, J, Kähäri, V-M
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Arsenite Biological and medical sciences Cell activation Cell Biology Cell physiology Cell proliferation Cell survival Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Collagen Collagenase 3 Dephosphorylation Development and progression Epithelium Extracellular signal-regulated kinase Fundamental and applied biological sciences. Psychology Gene expression Genetic aspects Genetic regulation Head & neck cancer Head and neck cancer Head and neck carcinoma Human Genetics Internal Medicine Interstitial collagenase Isoforms Keratinocytes Kinases MAP kinase Matrix metalloproteinase Medical sciences Medicine Medicine & Public Health MKK3 protein Molecular and cellular biology Oncology original-article Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Phenotypes Protein kinase Quantitation Severe combined immunodeficiency Signal transduction Squamous cell carcinoma Tumor cells Tumor suppressor genes Tumors Xenografts
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