P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation

p21 Cip1/WAF1 is a known inhibitor of the short-gap filling activity of proliferating cell nuclear antigen (PCNA) during DNA repair. In agreement, p21 degradation after UV irradiation promotes PCNA-dependent repair. Recent reports have identified ubiquitination of PCNA as a relevant feature for PCNA...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2006-05, Vol.25 (20), p.2829-2838
Hauptverfasser:	Soria, G, Podhajcer, O, Prives, C, Gottifredi, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Aphidicolin Aphidicolin - pharmacology Apoptosis Biological and medical sciences Cell Biology Cell Cycle - drug effects Cell Cycle - radiation effects Cell physiology Cell Proliferation - drug effects Cell Proliferation - radiation effects Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells, Cultured - drug effects Cells, Cultured - metabolism Cells, Cultured - radiation effects Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cyclin-dependent kinases Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects DNA Damage - radiation effects DNA repair DNA Repair - drug effects DNA Repair - radiation effects Down-Regulation Enzyme Inhibitors - pharmacology Fibroblasts - metabolism Fibroblasts - pathology Fundamental and applied biological sciences. Psychology Genotoxicity Human Genetics Humans Hydroxyurea Hydroxyurea - pharmacology Inhibitor drugs Internal Medicine Lung Neoplasms - metabolism Lung Neoplasms - pathology Medicine Medicine & Public Health Methyl Methanesulfonate - pharmacology Molecular and cellular biology Mutagens - pharmacology Nucleotide excision repair Oncology original-article Proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - metabolism Ubiquitin - metabolism Ubiquitination Ultraviolet radiation Ultraviolet Rays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!