Stability of nucleolar versus non-nucleolar forms of human p14ARF

Fusion proteins containing the amino-terminal domain of human p14 ARF linked to green fluorescent protein are able to bind MDM2 and stabilize p53 without localization in the nucleolus. However, these fusion proteins are inherently unstable, with half-lives considerably shorter than either authentic...

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Veröffentlicht in:	Oncogene 2004-08, Vol.23 (37), p.6186-6192
Hauptverfasser:	Rodway, Helen, Llanos, Susana, Rowe, Janice, Peters, Gordon
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Apoptosis Biological and medical sciences Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Fundamental and applied biological sciences. Psychology Green fluorescent protein Human Genetics Internal Medicine Localization MDM2 protein Medicine Medicine & Public Health Molecular and cellular biology Nucleoli Oncology original-paper p53 Protein Proteasomes Proteins
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