Nuclear export of adenovirus E4orf6 protein is necessary for its ability to antagonize apoptotic activity of BH3-only proteins

The adenovirus E4orf6 is a viral oncoprotein known to cooperate with the E1A gene product in transforming primary murine cells. It has been shown to inhibit the apoptotic activities of p53 and p73 through direct binding to these proteins. Here, we demonstrate that the adenovirus E4orf6 protein inhib...

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Veröffentlicht in:	Oncogene 2003-10, Vol.22 (44), p.6919-6927
Hauptverfasser:	Aoyagi, Mariko, Higashino, Fumihiro, Yasuda, Motoaki, Takahashi, Akiko, Sawada, Yukiharu, Totsuka, Yasunori, Kohgo, Takao, Sano, Hidehiko, Kobayashi, Masanobu, Shindoh, Masanobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Adenovirus E4 Proteins - chemistry Adenovirus E4 Proteins - genetics Adenovirus E4 Proteins - metabolism Adenoviruses Ageing, cell death Amino Acid Motifs Amino Acid Substitution Animals Apoptosis Apoptosis Regulatory Proteins Bcl-2 protein Biological and medical sciences BNIP3 protein Cell Biology Cell Nucleus - metabolism Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells, Cultured Cercopithecus aethiops Consensus Sequence Conserved Sequence COS Cells Cytoplasm Dentistry E1A protein E4orf6 protein Fundamental and applied biological sciences. Psychology Human Genetics Internal Medicine Localization Medicine Medicine & Public Health Membrane Potentials Membrane Proteins - antagonists & inhibitors Membrane Proteins - chemistry Membrane Proteins - metabolism Mitochondria Mitochondria - metabolism Molecular and cellular biology Mutagenesis, Site-Directed Nuclear transport Oncology original-paper p53 Protein Protein Structure, Secondary Protein Structure, Tertiary Protein transport Proteins Proteins - antagonists & inhibitors Proteins - metabolism Proto-Oncogene Proteins Recombinant Fusion Proteins - metabolism Signal Transduction Subcellular Fractions - metabolism Tumor Suppressor Proteins
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