Avian metapneumovirus subtype B vaccination in commercial broiler chicks: heterologous protection and selected host transcription responses to subtype A or B challenge
Avian metapneumovirus (aMPV) causes respiratory disease and drops in egg production in chickens, and is routinely controlled by vaccination. However, the host's immune response to virulent challenge in vaccinated or unvaccinated broiler chickens is poorly characterized. We show that subtype B v...
Gespeichert in:
| Veröffentlicht in: | Avian pathology 2022-04, Vol.51 (2), p.181-196 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 196 |
|---|---|
| container_issue | 2 |
| container_start_page | 181 |
| container_title | Avian pathology |
| container_volume | 51 |
| creator | Ball, Christopher Manswr, Basim Herrmann, Andreas Lemiere, Stephane Ganapathy, Kannan |
| description | Avian metapneumovirus (aMPV) causes respiratory disease and drops in egg production in chickens, and is routinely controlled by vaccination. However, the host's immune response to virulent challenge in vaccinated or unvaccinated broiler chickens is poorly characterized. We show that subtype B vaccination offers heterologous (subtype A challenge) and homologous (subtype B challenge) protection. Subtype B challenge caused significantly greater humoral antibody titres in vaccinated and unvaccinated chickens. In turbinate and lung tissues of unvaccinated-challenged chickens, IgA and IgY mRNA transcription was significantly up-regulated after subtype B challenge compared to subtype A. Cellular immunity (CD8-α and CD8-β) gene transcripts were significantly up-regulated during early and later stages of infection from subtype B or subtype A, respectively. Immune gene transcriptional responses (IL-1β, IL-6 and IL-18) were significantly up-regulated after challenge. Gene transcription results showed that mRNA expression levels of CD8-α, CD8-β, TLR3 and IL-6, particularly in turbinate and trachea tissues, are useful parameters to include in future aMPV vaccination-challenge studies. |
| doi_str_mv | 10.1080/03079457.2022.2036697 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_journals_2641214736</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2624193687</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-9045a8c85a48584297ea4b9d1e34318b661446f80b807cf8bcc6a7b484af1b8c3</originalsourceid><addsrcrecordid>eNp9kU9vFCEYxonR2G31I2hIvHiZCsOfYTy5NlZNmnjRM2HYd7pUBkZg1uwn8mvKdrc9ePACIfye5-HlQegVJZeUKPKOMNL1XHSXLWnbujAp--4JWlEuRcMYU0_R6sA0B-gMned8RwiRQrTP0RkTpO-ZaFfoz3rnTMATFDMHWKa4c2nJOC9D2c-AP-KdsdYFU1wM2AVs4zRBss54PKToPCRst87-zO_xFgqk6ONtrAZzigXsvcqEDc7g6wk2eBtzwSWZkG1y8_19gjzHkCHjEh-D1zimmm63xnsIt_ACPRuNz_DytF-gH9efvl99aW6-ff56tb5pLOe0ND3hwiirhOFKKN72HRg-9BsKjDOqBikp53JUZFCks6MarJWmG7jiZqSDsuwCvT361gF-LZCLnly24L0JUOfSrWw57ZlUXUXf_IPexSWF-rpKcdpS3jFZKXGkbIo5Jxj1nNxk0l5Tog9N6ocm9aFJfWqy6l6f3Jdhgs2j6qG6Cnw4Ai6MMU3md0x-o4vZ-5jG-sHWZc3-n_EXqz6wog</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2641214736</pqid></control><display><type>article</type><title>Avian metapneumovirus subtype B vaccination in commercial broiler chicks: heterologous protection and selected host transcription responses to subtype A or B challenge</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Ball, Christopher ; Manswr, Basim ; Herrmann, Andreas ; Lemiere, Stephane ; Ganapathy, Kannan</creator><creatorcontrib>Ball, Christopher ; Manswr, Basim ; Herrmann, Andreas ; Lemiere, Stephane ; Ganapathy, Kannan</creatorcontrib><description>Avian metapneumovirus (aMPV) causes respiratory disease and drops in egg production in chickens, and is routinely controlled by vaccination. However, the host's immune response to virulent challenge in vaccinated or unvaccinated broiler chickens is poorly characterized. We show that subtype B vaccination offers heterologous (subtype A challenge) and homologous (subtype B challenge) protection. Subtype B challenge caused significantly greater humoral antibody titres in vaccinated and unvaccinated chickens. In turbinate and lung tissues of unvaccinated-challenged chickens, IgA and IgY mRNA transcription was significantly up-regulated after subtype B challenge compared to subtype A. Cellular immunity (CD8-α and CD8-β) gene transcripts were significantly up-regulated during early and later stages of infection from subtype B or subtype A, respectively. Immune gene transcriptional responses (IL-1β, IL-6 and IL-18) were significantly up-regulated after challenge. Gene transcription results showed that mRNA expression levels of CD8-α, CD8-β, TLR3 and IL-6, particularly in turbinate and trachea tissues, are useful parameters to include in future aMPV vaccination-challenge studies.</description><identifier>ISSN: 0307-9457</identifier><identifier>EISSN: 1465-3338</identifier><identifier>DOI: 10.1080/03079457.2022.2036697</identifier><identifier>PMID: 35099352</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Animal tissues ; Animals ; Antibodies ; Antibodies, Viral ; Avian metapneumovirus ; Bone ; broiler chicken ; CD8 antigen ; Cell-mediated immunity ; Chickens ; cross-protection ; Defence mechanisms ; Egg production ; Gene expression ; gene transcription ; Homology ; IL-1β ; Immune response ; Immune system ; Immunity ; Immunity, Cellular ; Immunoglobulin A ; Interleukin 18 ; Interleukin 6 ; Metapneumovirus - genetics ; Paramyxoviridae Infections - prevention & control ; Paramyxoviridae Infections - veterinary ; Poultry ; Poultry Diseases ; Protection ; Respiratory diseases ; Respiratory disorders ; Tissue ; TLR3 protein ; Toll-like receptors ; Trachea ; Transcription ; Vaccination ; Vaccination - veterinary</subject><ispartof>Avian pathology, 2022-04, Vol.51 (2), p.181-196</ispartof><rights>2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group 2022</rights><rights>2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-9045a8c85a48584297ea4b9d1e34318b661446f80b807cf8bcc6a7b484af1b8c3</citedby><cites>FETCH-LOGICAL-c441t-9045a8c85a48584297ea4b9d1e34318b661446f80b807cf8bcc6a7b484af1b8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35099352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ball, Christopher</creatorcontrib><creatorcontrib>Manswr, Basim</creatorcontrib><creatorcontrib>Herrmann, Andreas</creatorcontrib><creatorcontrib>Lemiere, Stephane</creatorcontrib><creatorcontrib>Ganapathy, Kannan</creatorcontrib><title>Avian metapneumovirus subtype B vaccination in commercial broiler chicks: heterologous protection and selected host transcription responses to subtype A or B challenge</title><title>Avian pathology</title><addtitle>Avian Pathol</addtitle><description>Avian metapneumovirus (aMPV) causes respiratory disease and drops in egg production in chickens, and is routinely controlled by vaccination. However, the host's immune response to virulent challenge in vaccinated or unvaccinated broiler chickens is poorly characterized. We show that subtype B vaccination offers heterologous (subtype A challenge) and homologous (subtype B challenge) protection. Subtype B challenge caused significantly greater humoral antibody titres in vaccinated and unvaccinated chickens. In turbinate and lung tissues of unvaccinated-challenged chickens, IgA and IgY mRNA transcription was significantly up-regulated after subtype B challenge compared to subtype A. Cellular immunity (CD8-α and CD8-β) gene transcripts were significantly up-regulated during early and later stages of infection from subtype B or subtype A, respectively. Immune gene transcriptional responses (IL-1β, IL-6 and IL-18) were significantly up-regulated after challenge. Gene transcription results showed that mRNA expression levels of CD8-α, CD8-β, TLR3 and IL-6, particularly in turbinate and trachea tissues, are useful parameters to include in future aMPV vaccination-challenge studies.</description><subject>Animal tissues</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Viral</subject><subject>Avian metapneumovirus</subject><subject>Bone</subject><subject>broiler chicken</subject><subject>CD8 antigen</subject><subject>Cell-mediated immunity</subject><subject>Chickens</subject><subject>cross-protection</subject><subject>Defence mechanisms</subject><subject>Egg production</subject><subject>Gene expression</subject><subject>gene transcription</subject><subject>Homology</subject><subject>IL-1β</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Immunity, Cellular</subject><subject>Immunoglobulin A</subject><subject>Interleukin 18</subject><subject>Interleukin 6</subject><subject>Metapneumovirus - genetics</subject><subject>Paramyxoviridae Infections - prevention & control</subject><subject>Paramyxoviridae Infections - veterinary</subject><subject>Poultry</subject><subject>Poultry Diseases</subject><subject>Protection</subject><subject>Respiratory diseases</subject><subject>Respiratory disorders</subject><subject>Tissue</subject><subject>TLR3 protein</subject><subject>Toll-like receptors</subject><subject>Trachea</subject><subject>Transcription</subject><subject>Vaccination</subject><subject>Vaccination - veterinary</subject><issn>0307-9457</issn><issn>1465-3338</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><recordid>eNp9kU9vFCEYxonR2G31I2hIvHiZCsOfYTy5NlZNmnjRM2HYd7pUBkZg1uwn8mvKdrc9ePACIfye5-HlQegVJZeUKPKOMNL1XHSXLWnbujAp--4JWlEuRcMYU0_R6sA0B-gMned8RwiRQrTP0RkTpO-ZaFfoz3rnTMATFDMHWKa4c2nJOC9D2c-AP-KdsdYFU1wM2AVs4zRBss54PKToPCRst87-zO_xFgqk6ONtrAZzigXsvcqEDc7g6wk2eBtzwSWZkG1y8_19gjzHkCHjEh-D1zimmm63xnsIt_ACPRuNz_DytF-gH9efvl99aW6-ff56tb5pLOe0ND3hwiirhOFKKN72HRg-9BsKjDOqBikp53JUZFCks6MarJWmG7jiZqSDsuwCvT361gF-LZCLnly24L0JUOfSrWw57ZlUXUXf_IPexSWF-rpKcdpS3jFZKXGkbIo5Jxj1nNxk0l5Tog9N6ocm9aFJfWqy6l6f3Jdhgs2j6qG6Cnw4Ai6MMU3md0x-o4vZ-5jG-sHWZc3-n_EXqz6wog</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Ball, Christopher</creator><creator>Manswr, Basim</creator><creator>Herrmann, Andreas</creator><creator>Lemiere, Stephane</creator><creator>Ganapathy, Kannan</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>K9.</scope><scope>L.G</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>202204</creationdate><title>Avian metapneumovirus subtype B vaccination in commercial broiler chicks: heterologous protection and selected host transcription responses to subtype A or B challenge</title><author>Ball, Christopher ; Manswr, Basim ; Herrmann, Andreas ; Lemiere, Stephane ; Ganapathy, Kannan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-9045a8c85a48584297ea4b9d1e34318b661446f80b807cf8bcc6a7b484af1b8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animal tissues</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Viral</topic><topic>Avian metapneumovirus</topic><topic>Bone</topic><topic>broiler chicken</topic><topic>CD8 antigen</topic><topic>Cell-mediated immunity</topic><topic>Chickens</topic><topic>cross-protection</topic><topic>Defence mechanisms</topic><topic>Egg production</topic><topic>Gene expression</topic><topic>gene transcription</topic><topic>Homology</topic><topic>IL-1β</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity</topic><topic>Immunity, Cellular</topic><topic>Immunoglobulin A</topic><topic>Interleukin 18</topic><topic>Interleukin 6</topic><topic>Metapneumovirus - genetics</topic><topic>Paramyxoviridae Infections - prevention & control</topic><topic>Paramyxoviridae Infections - veterinary</topic><topic>Poultry</topic><topic>Poultry Diseases</topic><topic>Protection</topic><topic>Respiratory diseases</topic><topic>Respiratory disorders</topic><topic>Tissue</topic><topic>TLR3 protein</topic><topic>Toll-like receptors</topic><topic>Trachea</topic><topic>Transcription</topic><topic>Vaccination</topic><topic>Vaccination - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ball, Christopher</creatorcontrib><creatorcontrib>Manswr, Basim</creatorcontrib><creatorcontrib>Herrmann, Andreas</creatorcontrib><creatorcontrib>Lemiere, Stephane</creatorcontrib><creatorcontrib>Ganapathy, Kannan</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Avian pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ball, Christopher</au><au>Manswr, Basim</au><au>Herrmann, Andreas</au><au>Lemiere, Stephane</au><au>Ganapathy, Kannan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Avian metapneumovirus subtype B vaccination in commercial broiler chicks: heterologous protection and selected host transcription responses to subtype A or B challenge</atitle><jtitle>Avian pathology</jtitle><addtitle>Avian Pathol</addtitle><date>2022-04</date><risdate>2022</risdate><volume>51</volume><issue>2</issue><spage>181</spage><epage>196</epage><pages>181-196</pages><issn>0307-9457</issn><eissn>1465-3338</eissn><abstract>Avian metapneumovirus (aMPV) causes respiratory disease and drops in egg production in chickens, and is routinely controlled by vaccination. However, the host's immune response to virulent challenge in vaccinated or unvaccinated broiler chickens is poorly characterized. We show that subtype B vaccination offers heterologous (subtype A challenge) and homologous (subtype B challenge) protection. Subtype B challenge caused significantly greater humoral antibody titres in vaccinated and unvaccinated chickens. In turbinate and lung tissues of unvaccinated-challenged chickens, IgA and IgY mRNA transcription was significantly up-regulated after subtype B challenge compared to subtype A. Cellular immunity (CD8-α and CD8-β) gene transcripts were significantly up-regulated during early and later stages of infection from subtype B or subtype A, respectively. Immune gene transcriptional responses (IL-1β, IL-6 and IL-18) were significantly up-regulated after challenge. Gene transcription results showed that mRNA expression levels of CD8-α, CD8-β, TLR3 and IL-6, particularly in turbinate and trachea tissues, are useful parameters to include in future aMPV vaccination-challenge studies.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>35099352</pmid><doi>10.1080/03079457.2022.2036697</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-9457 |
| ispartof | Avian pathology, 2022-04, Vol.51 (2), p.181-196 |
| issn | 0307-9457 1465-3338 |
| language | eng |
| recordid | cdi_proquest_journals_2641214736 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animal tissues Animals Antibodies Antibodies, Viral Avian metapneumovirus Bone broiler chicken CD8 antigen Cell-mediated immunity Chickens cross-protection Defence mechanisms Egg production Gene expression gene transcription Homology IL-1β Immune response Immune system Immunity Immunity, Cellular Immunoglobulin A Interleukin 18 Interleukin 6 Metapneumovirus - genetics Paramyxoviridae Infections - prevention & control Paramyxoviridae Infections - veterinary Poultry Poultry Diseases Protection Respiratory diseases Respiratory disorders Tissue TLR3 protein Toll-like receptors Trachea Transcription Vaccination Vaccination - veterinary |
| title | Avian metapneumovirus subtype B vaccination in commercial broiler chicks: heterologous protection and selected host transcription responses to subtype A or B challenge |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T23%3A19%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Avian%20metapneumovirus%20subtype%20B%20vaccination%20in%20commercial%20broiler%20chicks:%20heterologous%20protection%20and%20selected%20host%20transcription%20responses%20to%20subtype%20A%20or%20B%20challenge&rft.jtitle=Avian%20pathology&rft.au=Ball,%20Christopher&rft.date=2022-04&rft.volume=51&rft.issue=2&rft.spage=181&rft.epage=196&rft.pages=181-196&rft.issn=0307-9457&rft.eissn=1465-3338&rft_id=info:doi/10.1080/03079457.2022.2036697&rft_dat=%3Cproquest_pubme%3E2624193687%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2641214736&rft_id=info:pmid/35099352&rfr_iscdi=true |