An emerging role of microplastics in the etiology of lung ground glass nodules
Background Microplastic pollution has become a serious global environmental threat. The abundance of microplastics in the air is an order of magnitude higher than that in other media, which means that all living animals breathing with lungs (including humans) cannot escape the fate of inhaling micro...
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| Veröffentlicht in: | Environmental sciences Europe 2022-12, Vol.34 (1), Article 25 |
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| creator | Chen, Qiqing Gao, Jiani Yu, Hairui Su, Hang Yang, Yan Cao, Yajuan Zhang, Qun Ren, Yijiu Hollert, Henner Shi, Huahong Chen, Chang Liu, Haipeng |
| description | Background
Microplastic pollution has become a serious global environmental threat. The abundance of microplastics in the air is an order of magnitude higher than that in other media, which means that all living animals breathing with lungs (including humans) cannot escape the fate of inhaling microplastics. However, there is no direct evidence to demonstrate what type and abundance of microplastics exist in lung tissue. In addition, whether the retention of microplastics and the long-term friction between microplastics and lung tissue are related to some respiratory diseases is largely unknown. Ground glass nodules (GGNs) are areas of lesions of homogeneous density and with hazy increase in density in the lung field that do not obscure the bronchovascular structure, which have been increasingly identified in past decades. Although their etiology is broad, the correlation of microplastics with GGNs remains elusive.
Results
In this study, we identified the presence of 65 microfibers, including 24 microplastics (> 20 μm) in 100 human lung tissues with μ-FTIR. The detection rate of microfibers in tumor was 58%, higher than that in normal tissue (46%), and 2/3 of microplastics were found in tumor. Microfibers seemed to be embedded in lung tissues, which was suggested by the in situ observation via LDIR. Additionally, sub-micron-sized plastic particles were also detected in some lung tissues with Raman. The abundance of microfibers in lung tissue gradually accumulated with the increase of age. Moreover, the detection rate in tumor of patients with higher microfiber exposure risk history was significantly higher than those with a relatively lower one, implying microfiber inhalation could be related to the formation of GGN. Further, serious weared surface of microfibers isolated from lung tissue emphasized a possible link of surface roughness to the disease progression.
Conclusions
Collectively, the existence of microplastics in human lung tissues was validated, and their correlation with GGN formation was preliminarily explored, which laid a foundation for future research on microplastic exposure in the etiology of lung cancer and other related respiratory diseases.
Graphical Abstract |
| doi_str_mv | 10.1186/s12302-022-00605-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2640574307</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2640574307</sourcerecordid><originalsourceid>FETCH-LOGICAL-c363t-35ddc55d388dab4866993bab9b882c2d17019756593462eadac89a6cccc78183</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EElXpD7CyxDrgR_xaVhUvqYJN95ZjOyFVahc7WfTvcQmCHSONZhbn3tFcAG4xusdY8oeMCUWkQqQ04ohV9AIsCFaoqgVml787EtdglfMelWJEipotwNs6QH_wqetDB1McPIwtPPQ2xeNg8tjbDPsAxw8P_djHIXanMzBMhe5SnIKDXeEyDNFNg8834Ko1Q_arn7kEu6fH3eal2r4_v27W28pSTseKMucsY45K6UxTS86Voo1pVCMlscRhgbASjDNFa068ccZKZbgtJSSWdAnuZttjip-Tz6PexymFclETXiMmaopEochMlW9yTr7Vx9QfTDppjPQ5OT0np0ty-js5TYuIzqJc4ND59Gf9j-oLTalwTQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2640574307</pqid></control><display><type>article</type><title>An emerging role of microplastics in the etiology of lung ground glass nodules</title><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Chen, Qiqing ; Gao, Jiani ; Yu, Hairui ; Su, Hang ; Yang, Yan ; Cao, Yajuan ; Zhang, Qun ; Ren, Yijiu ; Hollert, Henner ; Shi, Huahong ; Chen, Chang ; Liu, Haipeng</creator><creatorcontrib>Chen, Qiqing ; Gao, Jiani ; Yu, Hairui ; Su, Hang ; Yang, Yan ; Cao, Yajuan ; Zhang, Qun ; Ren, Yijiu ; Hollert, Henner ; Shi, Huahong ; Chen, Chang ; Liu, Haipeng</creatorcontrib><description>Background
Microplastic pollution has become a serious global environmental threat. The abundance of microplastics in the air is an order of magnitude higher than that in other media, which means that all living animals breathing with lungs (including humans) cannot escape the fate of inhaling microplastics. However, there is no direct evidence to demonstrate what type and abundance of microplastics exist in lung tissue. In addition, whether the retention of microplastics and the long-term friction between microplastics and lung tissue are related to some respiratory diseases is largely unknown. Ground glass nodules (GGNs) are areas of lesions of homogeneous density and with hazy increase in density in the lung field that do not obscure the bronchovascular structure, which have been increasingly identified in past decades. Although their etiology is broad, the correlation of microplastics with GGNs remains elusive.
Results
In this study, we identified the presence of 65 microfibers, including 24 microplastics (> 20 μm) in 100 human lung tissues with μ-FTIR. The detection rate of microfibers in tumor was 58%, higher than that in normal tissue (46%), and 2/3 of microplastics were found in tumor. Microfibers seemed to be embedded in lung tissues, which was suggested by the in situ observation via LDIR. Additionally, sub-micron-sized plastic particles were also detected in some lung tissues with Raman. The abundance of microfibers in lung tissue gradually accumulated with the increase of age. Moreover, the detection rate in tumor of patients with higher microfiber exposure risk history was significantly higher than those with a relatively lower one, implying microfiber inhalation could be related to the formation of GGN. Further, serious weared surface of microfibers isolated from lung tissue emphasized a possible link of surface roughness to the disease progression.
Conclusions
Collectively, the existence of microplastics in human lung tissues was validated, and their correlation with GGN formation was preliminarily explored, which laid a foundation for future research on microplastic exposure in the etiology of lung cancer and other related respiratory diseases.
Graphical Abstract</description><identifier>ISSN: 2190-4707</identifier><identifier>EISSN: 2190-4715</identifier><identifier>DOI: 10.1186/s12302-022-00605-3</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abundance ; Bioaccumulation ; Density ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Etiology ; Inhalation ; Lung cancer ; Lung nodules ; Microfibers ; Microplastics ; Nodules ; Plastic debris ; Plastic pollution ; Pollution ; Respiration ; Respiratory diseases ; Surface roughness ; Tissues ; Tumors</subject><ispartof>Environmental sciences Europe, 2022-12, Vol.34 (1), Article 25</ispartof><rights>The Author(s) 2022</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-35ddc55d388dab4866993bab9b882c2d17019756593462eadac89a6cccc78183</citedby><cites>FETCH-LOGICAL-c363t-35ddc55d388dab4866993bab9b882c2d17019756593462eadac89a6cccc78183</cites><orcidid>0000-0002-3247-7861</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1186/s12302-022-00605-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1186/s12302-022-00605-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,864,27924,27925,41120,41488,42189,42557,51319,51576</link.rule.ids></links><search><creatorcontrib>Chen, Qiqing</creatorcontrib><creatorcontrib>Gao, Jiani</creatorcontrib><creatorcontrib>Yu, Hairui</creatorcontrib><creatorcontrib>Su, Hang</creatorcontrib><creatorcontrib>Yang, Yan</creatorcontrib><creatorcontrib>Cao, Yajuan</creatorcontrib><creatorcontrib>Zhang, Qun</creatorcontrib><creatorcontrib>Ren, Yijiu</creatorcontrib><creatorcontrib>Hollert, Henner</creatorcontrib><creatorcontrib>Shi, Huahong</creatorcontrib><creatorcontrib>Chen, Chang</creatorcontrib><creatorcontrib>Liu, Haipeng</creatorcontrib><title>An emerging role of microplastics in the etiology of lung ground glass nodules</title><title>Environmental sciences Europe</title><addtitle>Environ Sci Eur</addtitle><description>Background
Microplastic pollution has become a serious global environmental threat. The abundance of microplastics in the air is an order of magnitude higher than that in other media, which means that all living animals breathing with lungs (including humans) cannot escape the fate of inhaling microplastics. However, there is no direct evidence to demonstrate what type and abundance of microplastics exist in lung tissue. In addition, whether the retention of microplastics and the long-term friction between microplastics and lung tissue are related to some respiratory diseases is largely unknown. Ground glass nodules (GGNs) are areas of lesions of homogeneous density and with hazy increase in density in the lung field that do not obscure the bronchovascular structure, which have been increasingly identified in past decades. Although their etiology is broad, the correlation of microplastics with GGNs remains elusive.
Results
In this study, we identified the presence of 65 microfibers, including 24 microplastics (> 20 μm) in 100 human lung tissues with μ-FTIR. The detection rate of microfibers in tumor was 58%, higher than that in normal tissue (46%), and 2/3 of microplastics were found in tumor. Microfibers seemed to be embedded in lung tissues, which was suggested by the in situ observation via LDIR. Additionally, sub-micron-sized plastic particles were also detected in some lung tissues with Raman. The abundance of microfibers in lung tissue gradually accumulated with the increase of age. Moreover, the detection rate in tumor of patients with higher microfiber exposure risk history was significantly higher than those with a relatively lower one, implying microfiber inhalation could be related to the formation of GGN. Further, serious weared surface of microfibers isolated from lung tissue emphasized a possible link of surface roughness to the disease progression.
Conclusions
Collectively, the existence of microplastics in human lung tissues was validated, and their correlation with GGN formation was preliminarily explored, which laid a foundation for future research on microplastic exposure in the etiology of lung cancer and other related respiratory diseases.
Graphical Abstract</description><subject>Abundance</subject><subject>Bioaccumulation</subject><subject>Density</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Etiology</subject><subject>Inhalation</subject><subject>Lung cancer</subject><subject>Lung nodules</subject><subject>Microfibers</subject><subject>Microplastics</subject><subject>Nodules</subject><subject>Plastic debris</subject><subject>Plastic pollution</subject><subject>Pollution</subject><subject>Respiration</subject><subject>Respiratory diseases</subject><subject>Surface roughness</subject><subject>Tissues</subject><subject>Tumors</subject><issn>2190-4707</issn><issn>2190-4715</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kMtOwzAQRS0EElXpD7CyxDrgR_xaVhUvqYJN95ZjOyFVahc7WfTvcQmCHSONZhbn3tFcAG4xusdY8oeMCUWkQqQ04ohV9AIsCFaoqgVml787EtdglfMelWJEipotwNs6QH_wqetDB1McPIwtPPQ2xeNg8tjbDPsAxw8P_djHIXanMzBMhe5SnIKDXeEyDNFNg8834Ko1Q_arn7kEu6fH3eal2r4_v27W28pSTseKMucsY45K6UxTS86Voo1pVCMlscRhgbASjDNFa068ccZKZbgtJSSWdAnuZttjip-Tz6PexymFclETXiMmaopEochMlW9yTr7Vx9QfTDppjPQ5OT0np0ty-js5TYuIzqJc4ND59Gf9j-oLTalwTQ</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Chen, Qiqing</creator><creator>Gao, Jiani</creator><creator>Yu, Hairui</creator><creator>Su, Hang</creator><creator>Yang, Yan</creator><creator>Cao, Yajuan</creator><creator>Zhang, Qun</creator><creator>Ren, Yijiu</creator><creator>Hollert, Henner</creator><creator>Shi, Huahong</creator><creator>Chen, Chang</creator><creator>Liu, Haipeng</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8C1</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><orcidid>https://orcid.org/0000-0002-3247-7861</orcidid></search><sort><creationdate>20221201</creationdate><title>An emerging role of microplastics in the etiology of lung ground glass nodules</title><author>Chen, Qiqing ; Gao, Jiani ; Yu, Hairui ; Su, Hang ; Yang, Yan ; Cao, Yajuan ; Zhang, Qun ; Ren, Yijiu ; Hollert, Henner ; Shi, Huahong ; Chen, Chang ; Liu, Haipeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-35ddc55d388dab4866993bab9b882c2d17019756593462eadac89a6cccc78183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abundance</topic><topic>Bioaccumulation</topic><topic>Density</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Etiology</topic><topic>Inhalation</topic><topic>Lung cancer</topic><topic>Lung nodules</topic><topic>Microfibers</topic><topic>Microplastics</topic><topic>Nodules</topic><topic>Plastic debris</topic><topic>Plastic pollution</topic><topic>Pollution</topic><topic>Respiration</topic><topic>Respiratory diseases</topic><topic>Surface roughness</topic><topic>Tissues</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Qiqing</creatorcontrib><creatorcontrib>Gao, Jiani</creatorcontrib><creatorcontrib>Yu, Hairui</creatorcontrib><creatorcontrib>Su, Hang</creatorcontrib><creatorcontrib>Yang, Yan</creatorcontrib><creatorcontrib>Cao, Yajuan</creatorcontrib><creatorcontrib>Zhang, Qun</creatorcontrib><creatorcontrib>Ren, Yijiu</creatorcontrib><creatorcontrib>Hollert, Henner</creatorcontrib><creatorcontrib>Shi, Huahong</creatorcontrib><creatorcontrib>Chen, Chang</creatorcontrib><creatorcontrib>Liu, Haipeng</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>Public Health Database</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environmental Science Collection</collection><jtitle>Environmental sciences Europe</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Qiqing</au><au>Gao, Jiani</au><au>Yu, Hairui</au><au>Su, Hang</au><au>Yang, Yan</au><au>Cao, Yajuan</au><au>Zhang, Qun</au><au>Ren, Yijiu</au><au>Hollert, Henner</au><au>Shi, Huahong</au><au>Chen, Chang</au><au>Liu, Haipeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An emerging role of microplastics in the etiology of lung ground glass nodules</atitle><jtitle>Environmental sciences Europe</jtitle><stitle>Environ Sci Eur</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>34</volume><issue>1</issue><artnum>25</artnum><issn>2190-4707</issn><eissn>2190-4715</eissn><abstract>Background
Microplastic pollution has become a serious global environmental threat. The abundance of microplastics in the air is an order of magnitude higher than that in other media, which means that all living animals breathing with lungs (including humans) cannot escape the fate of inhaling microplastics. However, there is no direct evidence to demonstrate what type and abundance of microplastics exist in lung tissue. In addition, whether the retention of microplastics and the long-term friction between microplastics and lung tissue are related to some respiratory diseases is largely unknown. Ground glass nodules (GGNs) are areas of lesions of homogeneous density and with hazy increase in density in the lung field that do not obscure the bronchovascular structure, which have been increasingly identified in past decades. Although their etiology is broad, the correlation of microplastics with GGNs remains elusive.
Results
In this study, we identified the presence of 65 microfibers, including 24 microplastics (> 20 μm) in 100 human lung tissues with μ-FTIR. The detection rate of microfibers in tumor was 58%, higher than that in normal tissue (46%), and 2/3 of microplastics were found in tumor. Microfibers seemed to be embedded in lung tissues, which was suggested by the in situ observation via LDIR. Additionally, sub-micron-sized plastic particles were also detected in some lung tissues with Raman. The abundance of microfibers in lung tissue gradually accumulated with the increase of age. Moreover, the detection rate in tumor of patients with higher microfiber exposure risk history was significantly higher than those with a relatively lower one, implying microfiber inhalation could be related to the formation of GGN. Further, serious weared surface of microfibers isolated from lung tissue emphasized a possible link of surface roughness to the disease progression.
Conclusions
Collectively, the existence of microplastics in human lung tissues was validated, and their correlation with GGN formation was preliminarily explored, which laid a foundation for future research on microplastic exposure in the etiology of lung cancer and other related respiratory diseases.
Graphical Abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s12302-022-00605-3</doi><orcidid>https://orcid.org/0000-0002-3247-7861</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abundance Bioaccumulation Density Earth and Environmental Science Ecotoxicology Environment Etiology Inhalation Lung cancer Lung nodules Microfibers Microplastics Nodules Plastic debris Plastic pollution Pollution Respiration Respiratory diseases Surface roughness Tissues Tumors |
| title | An emerging role of microplastics in the etiology of lung ground glass nodules |
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