An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis
Studies on the possible association between blood pressure and blood lead have reached divergent conclusions. In a previous meta-analysis, a doubling of the blood lead concentration was associated with a 1.0/0.6 mm Hg increase in systolic and diastolic blood pressure (BP). This meta-analysis updates...
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| Veröffentlicht in: | Journal of human hypertension 2002-02, Vol.16 (2), p.123-131 |
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| description | Studies on the possible association between blood pressure and blood lead have reached divergent conclusions. In a previous meta-analysis, a doubling of the blood lead concentration was associated with a 1.0/0.6 mm Hg increase in systolic and diastolic blood pressure (BP). This meta-analysis updates the analysis originally performed in 1994. Articles on the association between BP and blood lead were identified from computer searches from January 1980 to February 2001 using the Medical Literature Analysis and Retrieval System. Of the studies reviewed, 31 provided sufficient details to be considered. The meta-analysis included 58518 subjects recruited from the general population in 19 surveys and from occupationally exposed groups in 12 studies. In all but four studies, the results were adjusted for age, and most studies took into account additional confounding factors such as body mass index and the use of alcohol and medication. Weighted joint P-values were calculated using Stouffer's procedure. The association between BP and blood lead was similar in both men and women. In the combined studies, a two-fold increase in blood lead concentration was associated with a 1.0 mm Hg rise in the systolic pressure (95% CI +0.5 to +1.4 mm Hg; P < 0.001) and with a 0.6 mm Hg increase in the diastolic pressure (95% CI +0.4 to +0.8 mm Hg; P < 0.001). On balance, this meta-analysis suggests that there can only be a weak association between BP and blood lead. |
| doi_str_mv | 10.1038/sj.jhh.1001300 |
| format | Article |
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In a previous meta-analysis, a doubling of the blood lead concentration was associated with a 1.0/0.6 mm Hg increase in systolic and diastolic blood pressure (BP). This meta-analysis updates the analysis originally performed in 1994. Articles on the association between BP and blood lead were identified from computer searches from January 1980 to February 2001 using the Medical Literature Analysis and Retrieval System. Of the studies reviewed, 31 provided sufficient details to be considered. The meta-analysis included 58518 subjects recruited from the general population in 19 surveys and from occupationally exposed groups in 12 studies. In all but four studies, the results were adjusted for age, and most studies took into account additional confounding factors such as body mass index and the use of alcohol and medication. Weighted joint P-values were calculated using Stouffer's procedure. The association between BP and blood lead was similar in both men and women. In the combined studies, a two-fold increase in blood lead concentration was associated with a 1.0 mm Hg rise in the systolic pressure (95% CI +0.5 to +1.4 mm Hg; P < 0.001) and with a 0.6 mm Hg increase in the diastolic pressure (95% CI +0.4 to +0.8 mm Hg; P < 0.001). On balance, this meta-analysis suggests that there can only be a weak association between BP and blood lead.</description><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/sj.jhh.1001300</identifier><identifier>PMID: 11850770</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Belgium - epidemiology ; Blood levels ; Blood pressure ; Blood Pressure - physiology ; Blood Pressure Determination ; Body mass index ; Chi-Square Distribution ; Child ; Child, Preschool ; Comorbidity ; Epidemiology ; Female ; Humans ; Hypertension - diagnosis ; Hypertension - epidemiology ; Lead - blood ; Lead Poisoning - epidemiology ; Male ; Meta-analysis ; Middle Aged ; Probability ; Risk Assessment ; Risk Factors ; Sensitivity and Specificity ; Sex Distribution</subject><ispartof>Journal of human hypertension, 2002-02, Vol.16 (2), p.123-131</ispartof><rights>COPYRIGHT 2002 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Feb 2002</rights><rights>Macmillan Publishers Limited 2002.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-388d916532121d2657585d715ae82cf367ae6d06a6afc5f887d2f4ff7b410993</citedby><cites>FETCH-LOGICAL-c483t-388d916532121d2657585d715ae82cf367ae6d06a6afc5f887d2f4ff7b410993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11850770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nawrot, T S</creatorcontrib><creatorcontrib>Thijs, L</creatorcontrib><creatorcontrib>Den Hond, E M</creatorcontrib><creatorcontrib>Roels, H A</creatorcontrib><creatorcontrib>Staessen, J A</creatorcontrib><title>An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis</title><title>Journal of human hypertension</title><addtitle>J Hum Hypertens</addtitle><description>Studies on the possible association between blood pressure and blood lead have reached divergent conclusions. In a previous meta-analysis, a doubling of the blood lead concentration was associated with a 1.0/0.6 mm Hg increase in systolic and diastolic blood pressure (BP). This meta-analysis updates the analysis originally performed in 1994. Articles on the association between BP and blood lead were identified from computer searches from January 1980 to February 2001 using the Medical Literature Analysis and Retrieval System. Of the studies reviewed, 31 provided sufficient details to be considered. The meta-analysis included 58518 subjects recruited from the general population in 19 surveys and from occupationally exposed groups in 12 studies. In all but four studies, the results were adjusted for age, and most studies took into account additional confounding factors such as body mass index and the use of alcohol and medication. Weighted joint P-values were calculated using Stouffer's procedure. The association between BP and blood lead was similar in both men and women. In the combined studies, a two-fold increase in blood lead concentration was associated with a 1.0 mm Hg rise in the systolic pressure (95% CI +0.5 to +1.4 mm Hg; P < 0.001) and with a 0.6 mm Hg increase in the diastolic pressure (95% CI +0.4 to +0.8 mm Hg; P < 0.001). On balance, this meta-analysis suggests that there can only be a weak association between BP and blood lead.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Belgium - epidemiology</subject><subject>Blood levels</subject><subject>Blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Blood Pressure Determination</subject><subject>Body mass index</subject><subject>Chi-Square Distribution</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Comorbidity</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - diagnosis</subject><subject>Hypertension - epidemiology</subject><subject>Lead - blood</subject><subject>Lead Poisoning - epidemiology</subject><subject>Male</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Probability</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Sex Distribution</subject><issn>0950-9240</issn><issn>1476-5527</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kctv1DAQhy0EotvClSOKQOKWxY_4EW6rCgpSJS69W9543DjyroMnEep_X1cbiROneX3z0PwI-cDonlFhvuK0n8ax-pQJSl-RHeu0aqXk-jXZ0V7StucdvSLXiFNlatG8JVeMGUm1pjsSD-cG5ujhFHPKj3FwqSnQunkuLmINcmiWERqHmIfolpjPzRGWvwDVppx9MxdAXEtFzn5LJXD-W-OaEyyudWeXnjDiO_ImuITwfrM35OHH94fbn-3977tft4f7duiMWFphjO-ZkoIzzjxXUksjvWbSgeFDEEo7UJ4qp1wYZDBGex66EPSxY7TvxQ35fBk7l_xnBVzslNdSb0DLVUelFh3jlfr0X4r1vaLGiAp9uUCPLoEdwaVlxJzWlyegPfD6T95dpu0v4FAyYoFg5xJPrjxZRu2LTBYnW2Wym0y14eO2fj2ewP_DN13EM1cnjOE</recordid><startdate>20020201</startdate><enddate>20020201</enddate><creator>Nawrot, T S</creator><creator>Thijs, L</creator><creator>Den Hond, E M</creator><creator>Roels, H A</creator><creator>Staessen, J A</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20020201</creationdate><title>An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis</title><author>Nawrot, T S ; Thijs, L ; Den Hond, E M ; Roels, H A ; Staessen, J A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-388d916532121d2657585d715ae82cf367ae6d06a6afc5f887d2f4ff7b410993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Belgium - epidemiology</topic><topic>Blood levels</topic><topic>Blood pressure</topic><topic>Blood Pressure - physiology</topic><topic>Blood Pressure Determination</topic><topic>Body mass index</topic><topic>Chi-Square Distribution</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Comorbidity</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - diagnosis</topic><topic>Hypertension - epidemiology</topic><topic>Lead - blood</topic><topic>Lead Poisoning - epidemiology</topic><topic>Male</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Probability</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Sex Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nawrot, T S</creatorcontrib><creatorcontrib>Thijs, L</creatorcontrib><creatorcontrib>Den Hond, E M</creatorcontrib><creatorcontrib>Roels, H A</creatorcontrib><creatorcontrib>Staessen, J A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Journal of human hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nawrot, T S</au><au>Thijs, L</au><au>Den Hond, E M</au><au>Roels, H A</au><au>Staessen, J A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis</atitle><jtitle>Journal of human hypertension</jtitle><addtitle>J Hum Hypertens</addtitle><date>2002-02-01</date><risdate>2002</risdate><volume>16</volume><issue>2</issue><spage>123</spage><epage>131</epage><pages>123-131</pages><issn>0950-9240</issn><eissn>1476-5527</eissn><abstract>Studies on the possible association between blood pressure and blood lead have reached divergent conclusions. In a previous meta-analysis, a doubling of the blood lead concentration was associated with a 1.0/0.6 mm Hg increase in systolic and diastolic blood pressure (BP). This meta-analysis updates the analysis originally performed in 1994. Articles on the association between BP and blood lead were identified from computer searches from January 1980 to February 2001 using the Medical Literature Analysis and Retrieval System. Of the studies reviewed, 31 provided sufficient details to be considered. The meta-analysis included 58518 subjects recruited from the general population in 19 surveys and from occupationally exposed groups in 12 studies. In all but four studies, the results were adjusted for age, and most studies took into account additional confounding factors such as body mass index and the use of alcohol and medication. Weighted joint P-values were calculated using Stouffer's procedure. The association between BP and blood lead was similar in both men and women. In the combined studies, a two-fold increase in blood lead concentration was associated with a 1.0 mm Hg rise in the systolic pressure (95% CI +0.5 to +1.4 mm Hg; P < 0.001) and with a 0.6 mm Hg increase in the diastolic pressure (95% CI +0.4 to +0.8 mm Hg; P < 0.001). On balance, this meta-analysis suggests that there can only be a weak association between BP and blood lead.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>11850770</pmid><doi>10.1038/sj.jhh.1001300</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of human hypertension, 2002-02, Vol.16 (2), p.123-131 |
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| subjects | Adolescent Adult Age Distribution Aged Aged, 80 and over Belgium - epidemiology Blood levels Blood pressure Blood Pressure - physiology Blood Pressure Determination Body mass index Chi-Square Distribution Child Child, Preschool Comorbidity Epidemiology Female Humans Hypertension - diagnosis Hypertension - epidemiology Lead - blood Lead Poisoning - epidemiology Male Meta-analysis Middle Aged Probability Risk Assessment Risk Factors Sensitivity and Specificity Sex Distribution |
| title | An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis |
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