The addition of mibefradil to chronic hydrochlorothiazide therapy in hypertensive patients is associated with a significant antihypertensive effect

To evaluate the antihypertensive efficacy, tolerability, safety, and dose-response characteristics of the novel calcium antagonist, mibefradil, in combination with a diuretic regimen. A multinational, double-blind, randomised, placebo-controlled, parallel-design trial. Three hundred and seven patien...

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Veröffentlicht in:	Journal of human hypertension 1997-07, Vol.11 (7), p.459-466
Hauptverfasser:	CARNEY, S, WING, L, RIBEIRO, A, KALLWELLIS, R, ZIMLICHMAN, R, VISKOPER, R. J, MION, D. JR, KOBRIN, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antihypertensive agents Antihypertensives Benzimidazoles - administration & dosage Benzimidazoles - adverse effects Biological and medical sciences Blood pressure Calcium antagonists Calcium Channel Blockers - administration & dosage Cardiovascular system Diuretics Double-Blind Method Drug Therapy, Combination Female Humans Hydrochlorothiazide Hydrochlorothiazide - administration & dosage Hydrochlorothiazide - adverse effects Hypertension Hypertension - drug therapy Male Medical sciences Mibefradil Middle Aged Patients Pharmacology. Drug treatments Placebos Sodium Chloride Symporter Inhibitors - administration & dosage Tetrahydronaphthalenes - administration & dosage Tetrahydronaphthalenes - adverse effects
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