A Short and Versatile Approach for the Synthesis of Pyrrolizidinones

Herein we describe a novel 3‐step synthesis of pyrrolizidinone derivatives with good overall yield. This sequence relies on first a [2+2] cycloaddition between a keteniminium salt intermediate, bearing an alkyl chloride side chain, and an alkene partner furnishing the corresponding cyclobutanone aft...

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Veröffentlicht in:	Helvetica chimica acta 2022-03, Vol.105 (3), p.n/a
Hauptverfasser:	Dagoneau, Dylan, Quinodoz, Pierre, Kolleth, Amandine, Bozoflu, Mert, Horoz, Beyza, Catak, Saron, Poisson, Philippe‐Alexandre, Lumbroso, Alexandre, Sulzer‐Mossé, Sarah, De Mesmaeker, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Amides Beckmann rearrangement Computer applications Cycloaddition Intermediates keteniminium salts nucleophilic substitution pyrrolizidine pyrrolizidinone Synthesis
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