Drug-resistant tuberculosis in Naples, 2008-2013

Drug-resistant tuberculosis (TB) is a serious threat in industrialized countries, but information from Southern Italy is lacking. Here, we present the results of a retrospective study of TB cases diagnosed in 2008-2013 in Naples, the largest city in Southern Italy. Six hundred ninety Mycobacterium t...

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Veröffentlicht in:	Annali dell'Istituto superiore di sanità 2016-10, Vol.52 (4), p.603
Hauptverfasser:	Del Giudice, Annalisa, Mustazzolu, Alessandro, Iacobino, Angelo, Perna, Rossella, Smeraglia, Riccardo, Marino, Rachele, Fattorini, Lanfranco, Santoro, Giulia
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Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Child Child, Preschool Drug resistance Drug Resistance, Multiple, Bacterial Female Humans Infant Male Microbial Sensitivity Tests Middle Aged Mycobacterium tuberculosis - drug effects Nepal - epidemiology Retrospective Studies Transients and Migrants Tuberculosis Tuberculosis, Multidrug-Resistant - epidemiology Tuberculosis, Multidrug-Resistant - microbiology Young Adult
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creator	Del Giudice, Annalisa Mustazzolu, Alessandro Iacobino, Angelo Perna, Rossella Smeraglia, Riccardo Marino, Rachele Fattorini, Lanfranco Santoro, Giulia
description	Drug-resistant tuberculosis (TB) is a serious threat in industrialized countries, but information from Southern Italy is lacking. Here, we present the results of a retrospective study of TB cases diagnosed in 2008-2013 in Naples, the largest city in Southern Italy. Six hundred ninety Mycobacterium tuberculosis strains were isolated at the Ospedali dei Colli of Naples, and resistance to first-line and second-line drugs was determined. Multidrug-resistant (MDR) TB increased from 2008 to 2013, with 77.4% of strains isolated from migrants from 41 countries. Overall, 4.5% of strains were MDR: Italian-born persons, 2.2%; Romania, 7.5%; Former Soviet Union countries (Ukraine, Russia, Armenia, Georgia), 22.4%; all other foreign countries, 2.0%. Resistance of MDR strains to second-line drugs was high against kanamycin, ofloxacin, capreomycin. MDR-TB in Naples increased in 2008-13 and was observed predominantly in migrants, indicating the need to intensify diagnosis and treatment of these populations in this town.
doi_str_mv	10.4415/ANN_16_04_23
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subjects	Adolescent Adult Aged Aged, 80 and over Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Child Child, Preschool Drug resistance Drug Resistance, Multiple, Bacterial Female Humans Infant Male Microbial Sensitivity Tests Middle Aged Mycobacterium tuberculosis - drug effects Nepal - epidemiology Retrospective Studies Transients and Migrants Tuberculosis Tuberculosis, Multidrug-Resistant - epidemiology Tuberculosis, Multidrug-Resistant - microbiology Young Adult
title	Drug-resistant tuberculosis in Naples, 2008-2013
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