Genetic Encoding of Cyanopyridylalanine for In‐Cell Protein Macrocyclization by the Nitrile–Aminothiol Click Reaction

Cyanopyridylalanines are non‐canonical amino acids that react with aminothiol compounds under physiological conditions in a biocompatible manner without requiring added catalyst. Here we present newly developed aminoacyl‐tRNA synthetases for genetic encoding of meta‐ and para‐cyanopyridylalanine to...

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Veröffentlicht in:	Angewandte Chemie 2022-03, Vol.134 (13), p.n/a
Hauptverfasser:	Abdelkader, Elwy H., Qianzhu, Haocheng, George, Josemon, Frkic, Rebecca L., Jackson, Colin J., Nitsche, Christoph, Otting, Gottfried, Huber, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Biocompatibility Bioorthogonal Reaction Catalysts Chemical reactions Chemistry Cyanopyridylalanine Genetic Encoding Noncanonical Amino Acids Peptides Protein Conjugation Proteins tRNA
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