Fabrication of PDMS chips by laser engraving for protein enrichments
PDMS (Polydimethylsiloxane) chips are increasingly important for the application of fluorescence measurements due to their auto-fluorescence free, excellent transparency, and biocompatibility. However, the design of PDMS microfluidic chips requires to fabricate plenty of molds for structure optimiza...
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| Veröffentlicht in: | Journal of Electrical Engineering 2022-02, Vol.73 (1), p.43-49 |
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| creator | Sun, Linlin Ding, Ao Chen, Yangbo Yang, Xue Yin, Zhifu Fang, Yuqiang |
| description | PDMS (Polydimethylsiloxane) chips are increasingly important for the application of fluorescence measurements due to their auto-fluorescence free, excellent transparency, and biocompatibility. However, the design of PDMS microfluidic chips requires to fabricate plenty of molds for structure optimization, resulting in high cost. In the present, PDMS chips with nafion membrane were fabricated by simple and low-cost method for bull serum albumin (BSA) enrichment. To optimize the laser cutting and bonding parameters, simulation models were established using Bilinear Kinematic and Mooney-Rivlin models, respectively. The influence of laser power and cutting speed on the width and depth of the micro-channels was investigated. And the effect of bonding pressure on the deformation of PDMS micro-channel and stress distribution near the micro-channels was also analyzed. The leakage test and BSA enrichment demonstrated the practicability and feasibility of the present fabrication method in this work. |
| doi_str_mv | 10.2478/jee-2022-0006 |
| format | Article |
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However, the design of PDMS microfluidic chips requires to fabricate plenty of molds for structure optimization, resulting in high cost. In the present, PDMS chips with nafion membrane were fabricated by simple and low-cost method for bull serum albumin (BSA) enrichment. To optimize the laser cutting and bonding parameters, simulation models were established using Bilinear Kinematic and Mooney-Rivlin models, respectively. The influence of laser power and cutting speed on the width and depth of the micro-channels was investigated. And the effect of bonding pressure on the deformation of PDMS micro-channel and stress distribution near the micro-channels was also analyzed. The leakage test and BSA enrichment demonstrated the practicability and feasibility of the present fabrication method in this work.</description><identifier>ISSN: 1339-309X</identifier><identifier>ISSN: 1335-3632</identifier><identifier>EISSN: 1339-309X</identifier><identifier>DOI: 10.2478/jee-2022-0006</identifier><language>eng</language><publisher>Bratislava: Sciendo</publisher><subject>Biocompatibility ; Bonding ; Chip formation ; Cutting parameters ; Cutting speed ; Deformation effects ; Engraving ; Enrichment ; Fluorescence ; Laser beam cutting ; laser cutting ; Lasers ; Microchannels ; microfluidic chip ; Microfluidics ; numerical simulation ; Optimization ; Polydimethylsiloxane ; Pressure effects ; protein enrichment ; Serum albumin ; Stress distribution</subject><ispartof>Journal of Electrical Engineering, 2022-02, Vol.73 (1), p.43-49</ispartof><rights>2022. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-16510c5cf85dae627b38b6d1edbbc4dbdd472bd5fc52c067231e36d9bb7674a3</citedby><cites>FETCH-LOGICAL-c355t-16510c5cf85dae627b38b6d1edbbc4dbdd472bd5fc52c067231e36d9bb7674a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://sciendo.com/pdf/10.2478/jee-2022-0006$$EPDF$$P50$$Gwalterdegruyter$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://sciendo.com/article/10.2478/jee-2022-0006$$EHTML$$P50$$Gwalterdegruyter$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27901,27902,75907,75908</link.rule.ids></links><search><creatorcontrib>Sun, Linlin</creatorcontrib><creatorcontrib>Ding, Ao</creatorcontrib><creatorcontrib>Chen, Yangbo</creatorcontrib><creatorcontrib>Yang, Xue</creatorcontrib><creatorcontrib>Yin, Zhifu</creatorcontrib><creatorcontrib>Fang, Yuqiang</creatorcontrib><title>Fabrication of PDMS chips by laser engraving for protein enrichments</title><title>Journal of Electrical Engineering</title><description>PDMS (Polydimethylsiloxane) chips are increasingly important for the application of fluorescence measurements due to their auto-fluorescence free, excellent transparency, and biocompatibility. However, the design of PDMS microfluidic chips requires to fabricate plenty of molds for structure optimization, resulting in high cost. In the present, PDMS chips with nafion membrane were fabricated by simple and low-cost method for bull serum albumin (BSA) enrichment. To optimize the laser cutting and bonding parameters, simulation models were established using Bilinear Kinematic and Mooney-Rivlin models, respectively. The influence of laser power and cutting speed on the width and depth of the micro-channels was investigated. And the effect of bonding pressure on the deformation of PDMS micro-channel and stress distribution near the micro-channels was also analyzed. The leakage test and BSA enrichment demonstrated the practicability and feasibility of the present fabrication method in this work.</description><subject>Biocompatibility</subject><subject>Bonding</subject><subject>Chip formation</subject><subject>Cutting parameters</subject><subject>Cutting speed</subject><subject>Deformation effects</subject><subject>Engraving</subject><subject>Enrichment</subject><subject>Fluorescence</subject><subject>Laser beam cutting</subject><subject>laser cutting</subject><subject>Lasers</subject><subject>Microchannels</subject><subject>microfluidic chip</subject><subject>Microfluidics</subject><subject>numerical simulation</subject><subject>Optimization</subject><subject>Polydimethylsiloxane</subject><subject>Pressure effects</subject><subject>protein enrichment</subject><subject>Serum albumin</subject><subject>Stress distribution</subject><issn>1339-309X</issn><issn>1335-3632</issn><issn>1339-309X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkM1LAzEQxYMoWGqP3gOeV_OdXW_SWhUqCvbgLeRjtt3S7tZkq_S_N6WCHjzNY_i9N8ND6JKSayZ0ebMCKBhhrCCEqBM0oJxXBSfV--kffY5GKa0yQUXFBFEDNJlaFxtv-6ZrcVfj18nzG_bLZpuw2-O1TRAxtItoP5t2gesu4m3semjavM2-5QbaPl2gs9quE4x-5hDNp_fz8WMxe3l4Gt_NCs-l7AuqJCVe-rqUwYJi2vHSqUAhOOdFcCEIzVyQtZfME6UZp8BVqJzTSgvLh-jqGJtf-NhB6s2q28U2XzRM8VIqRbNniIoj5WOXUoTabGOzsXFvKDGHqkyuyhyqMoeqMn975L_suocYYBF3-yx-w__1aU4F598F129C</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Sun, Linlin</creator><creator>Ding, Ao</creator><creator>Chen, Yangbo</creator><creator>Yang, Xue</creator><creator>Yin, Zhifu</creator><creator>Fang, Yuqiang</creator><general>Sciendo</general><general>De Gruyter Poland</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>L6V</scope><scope>L7M</scope><scope>M7S</scope><scope>P5Z</scope><scope>P62</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope></search><sort><creationdate>20220201</creationdate><title>Fabrication of PDMS chips by laser engraving for protein enrichments</title><author>Sun, Linlin ; 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| source | De Gruyter Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biocompatibility Bonding Chip formation Cutting parameters Cutting speed Deformation effects Engraving Enrichment Fluorescence Laser beam cutting laser cutting Lasers Microchannels microfluidic chip Microfluidics numerical simulation Optimization Polydimethylsiloxane Pressure effects protein enrichment Serum albumin Stress distribution |
| title | Fabrication of PDMS chips by laser engraving for protein enrichments |
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