The role of metal ions in G protein‐coupled receptor signalling and drug discovery

Metal ions, such as Na+, Mg2+, Ca2+, and Zn2+, are highly abundant in biological systems. For many G protein‐coupled receptors (GPCRs), metal ions, especially Na+, have been found to stabilize the receptors' inactivate state preventing receptor activation. Besides this role, recent studies indi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Wiley interdisciplinary reviews. Computational molecular science 2022-03, Vol.12 (2), p.e1565-n/a
Hauptverfasser:	Zou, Rongfeng, Wang, Xueying, Li, Shu, Chan, H. C. Stephen, Vogel, Horst, Yuan, Shuguang
Format:	Artikel
Sprache:	eng
Schlagworte:	allosteric ions Allosteric properties Calcium ions Chemical compounds Coupling (molecular) Drug discovery Drugs G protein-coupled receptors GPCRs Magnesium Mechanics Metal ions Metals molecular dynamics simulation Molecular interactions Molecular structure orthosteric ions Pharmacology Proteins Receptor mechanisms Receptors Signaling Sodium Statistical mechanics Statistics structural biology Zinc
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!