Understanding autism spectrum disorders with animal models: applications, insights, and perspectives
Autism spectrum disorder (ASD) is typically characterized by common deficits in social skills and repetitive/stereotyped behaviors. It is widely accepted that genetic and environmental factors solely or in combination cause ASD. However, the underlying pathogenic mechanism is unclear due to its high...
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| Veröffentlicht in: | Dōngwùxué yánjiū 2021-11, Vol.42 (6), p.800-824 |
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| creator | Li, Zhu Zhu, Yuan-Xiang Gu, Li-Jun Cheng, Ying |
| description | Autism spectrum disorder (ASD) is typically characterized by common deficits in social skills and repetitive/stereotyped behaviors. It is widely accepted that genetic and environmental factors solely or in combination cause ASD. However, the underlying pathogenic mechanism is unclear due to its highly heterogeneous nature. To better understand the pathogenesis of ASD, various animal models have been generated, which can be generally divided into genetic, environment-induced, and idiopathic animal models. In this review, we summarize the common animals used for ASD study and then discuss the applications, clinical insights, as well as challenges and prospects of current ASD animal models. |
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In this review, we summarize the common animals used for ASD study and then discuss the applications, clinical insights, as well as challenges and prospects of current ASD animal models.</description><identifier>ISSN: 0254-5853</identifier><language>eng</language><publisher>Kunming: Kunming Institute of Zoology, The Chinese Academy of Sciences</publisher><subject>Animal cognition ; Animal models ; Autism ; Behavior ; Communication ; Dogs ; Environmental factors ; Genetics ; Genomes ; Neurosciences ; Pathogenesis ; Rodents ; Schizophrenia ; Stereotyped behavior</subject><ispartof>Dōngwùxué yánjiū, 2021-11, Vol.42 (6), p.800-824</ispartof><rights>Copyright Kunming Institute of Zoology, The Chinese Academy of Sciences Nov 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Li, Zhu</creatorcontrib><creatorcontrib>Zhu, Yuan-Xiang</creatorcontrib><creatorcontrib>Gu, Li-Jun</creatorcontrib><creatorcontrib>Cheng, Ying</creatorcontrib><title>Understanding autism spectrum disorders with animal models: applications, insights, and perspectives</title><title>Dōngwùxué yánjiū</title><description>Autism spectrum disorder (ASD) is typically characterized by common deficits in social skills and repetitive/stereotyped behaviors. 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| ispartof | Dōngwùxué yánjiū, 2021-11, Vol.42 (6), p.800-824 |
| issn | 0254-5853 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Bioline International; PubMed Central |
| subjects | Animal cognition Animal models Autism Behavior Communication Dogs Environmental factors Genetics Genomes Neurosciences Pathogenesis Rodents Schizophrenia Stereotyped behavior |
| title | Understanding autism spectrum disorders with animal models: applications, insights, and perspectives |
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