Synthesis and Anticancer Activity of 3,4,5-Trimethoxycinnamamide-Tethered 1,2,3-Triazole Derivatives
A series of novel 3,4,5-trimethoxycinnamamide-tethered 1,2,3-triazole derivatives were prepared by the click reaction of ( E )- N -(prop-2-yn-1-yl)-3-(3,4,5-trimethoxyphenyl) acrylamide with different aryl azides. The synthesized compounds were characterized by 1 H and 13 C NMR and mass spectra and...
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| Veröffentlicht in: | Russian journal of organic chemistry 2022, Vol.58 (1), p.87-93 |
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| container_title | Russian journal of organic chemistry |
| container_volume | 58 |
| creator | Sanjeev, A. Reddy, N. N. Bhaskar, S. Rohini, R. Raju, A. K. Kumar, B. V. Hu, A. Reddy, P. M. |
| description | A series of novel 3,4,5-trimethoxycinnamamide-tethered 1,2,3-triazole derivatives were prepared by the click reaction of (
E
)-
N
-(prop-2-yn-1-yl)-3-(3,4,5-trimethoxyphenyl) acrylamide with different aryl azides. The synthesized compounds were characterized by
1
H and
13
C NMR and mass spectra and elemental analyses and were screened for their in vitro anticancer activity against MCF-7 and A549 cell lines by using MTT assay. Most of the tested compounds showed prominent activity against both cancer cell lines. |
| doi_str_mv | 10.1134/S1070428022010122 |
| format | Article |
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E
)-
N
-(prop-2-yn-1-yl)-3-(3,4,5-trimethoxyphenyl) acrylamide with different aryl azides. The synthesized compounds were characterized by
1
H and
13
C NMR and mass spectra and elemental analyses and were screened for their in vitro anticancer activity against MCF-7 and A549 cell lines by using MTT assay. Most of the tested compounds showed prominent activity against both cancer cell lines.</description><identifier>ISSN: 1070-4280</identifier><identifier>EISSN: 1608-3393</identifier><identifier>DOI: 10.1134/S1070428022010122</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Acrylamide ; Anticancer properties ; Cancer ; Chemical reactions ; Chemistry ; Chemistry and Materials Science ; Mass spectra ; NMR ; Nuclear magnetic resonance ; Organic Chemistry ; Triazoles</subject><ispartof>Russian journal of organic chemistry, 2022, Vol.58 (1), p.87-93</ispartof><rights>Pleiades Publishing, Ltd. 2022</rights><rights>Pleiades Publishing, Ltd. 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c268t-d374d9a3abe4ea7fef0d24fa0e549f6a8c8d2816093c06125501790126e06c8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1070428022010122$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1070428022010122$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Sanjeev, A.</creatorcontrib><creatorcontrib>Reddy, N. N.</creatorcontrib><creatorcontrib>Bhaskar, S.</creatorcontrib><creatorcontrib>Rohini, R.</creatorcontrib><creatorcontrib>Raju, A. K.</creatorcontrib><creatorcontrib>Kumar, B. V.</creatorcontrib><creatorcontrib>Hu, A.</creatorcontrib><creatorcontrib>Reddy, P. M.</creatorcontrib><title>Synthesis and Anticancer Activity of 3,4,5-Trimethoxycinnamamide-Tethered 1,2,3-Triazole Derivatives</title><title>Russian journal of organic chemistry</title><addtitle>Russ J Org Chem</addtitle><description>A series of novel 3,4,5-trimethoxycinnamamide-tethered 1,2,3-triazole derivatives were prepared by the click reaction of (
E
)-
N
-(prop-2-yn-1-yl)-3-(3,4,5-trimethoxyphenyl) acrylamide with different aryl azides. The synthesized compounds were characterized by
1
H and
13
C NMR and mass spectra and elemental analyses and were screened for their in vitro anticancer activity against MCF-7 and A549 cell lines by using MTT assay. Most of the tested compounds showed prominent activity against both cancer cell lines.</description><subject>Acrylamide</subject><subject>Anticancer properties</subject><subject>Cancer</subject><subject>Chemical reactions</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Mass spectra</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Organic Chemistry</subject><subject>Triazoles</subject><issn>1070-4280</issn><issn>1608-3393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1UEtLAzEQDqJgrf4Abwteuzp5bDZ7LPUJBQ-t5yVNZm1Km63Jtrj-elMqeBBPM8z3GL6PkGsKt5RycTejUIJgChgDCpSxEzKgElTOecVP057g_ICfk4sYVwAgqOADYme975YYXcy0t9nYd85obzBkY9O5vev6rG0yPhKjIp8Ht8Fu2X72xnmvN3rjLObzdMKANqMjNuIHkv5q15jdY3B7nTwwXpKzRq8jXv3MIXl7fJhPnvPp69PLZDzNDZOqyy0vha001wsUqMsGG7BMNBqwEFUjtTLKMpVSVdyApKwogJZVCisRpFELPiQ3R99taD92GLt61e6CTy9rJrlQMpUjEoseWSa0MQZs6m0KpkNfU6gPZdZ_ykwadtTExPXvGH6d_xd9A7pZdKs</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Sanjeev, A.</creator><creator>Reddy, N. N.</creator><creator>Bhaskar, S.</creator><creator>Rohini, R.</creator><creator>Raju, A. K.</creator><creator>Kumar, B. V.</creator><creator>Hu, A.</creator><creator>Reddy, P. M.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2022</creationdate><title>Synthesis and Anticancer Activity of 3,4,5-Trimethoxycinnamamide-Tethered 1,2,3-Triazole Derivatives</title><author>Sanjeev, A. ; Reddy, N. N. ; Bhaskar, S. ; Rohini, R. ; Raju, A. K. ; Kumar, B. V. ; Hu, A. ; Reddy, P. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-d374d9a3abe4ea7fef0d24fa0e549f6a8c8d2816093c06125501790126e06c8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acrylamide</topic><topic>Anticancer properties</topic><topic>Cancer</topic><topic>Chemical reactions</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Mass spectra</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Organic Chemistry</topic><topic>Triazoles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sanjeev, A.</creatorcontrib><creatorcontrib>Reddy, N. N.</creatorcontrib><creatorcontrib>Bhaskar, S.</creatorcontrib><creatorcontrib>Rohini, R.</creatorcontrib><creatorcontrib>Raju, A. K.</creatorcontrib><creatorcontrib>Kumar, B. V.</creatorcontrib><creatorcontrib>Hu, A.</creatorcontrib><creatorcontrib>Reddy, P. M.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of organic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sanjeev, A.</au><au>Reddy, N. N.</au><au>Bhaskar, S.</au><au>Rohini, R.</au><au>Raju, A. K.</au><au>Kumar, B. V.</au><au>Hu, A.</au><au>Reddy, P. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and Anticancer Activity of 3,4,5-Trimethoxycinnamamide-Tethered 1,2,3-Triazole Derivatives</atitle><jtitle>Russian journal of organic chemistry</jtitle><stitle>Russ J Org Chem</stitle><date>2022</date><risdate>2022</risdate><volume>58</volume><issue>1</issue><spage>87</spage><epage>93</epage><pages>87-93</pages><issn>1070-4280</issn><eissn>1608-3393</eissn><abstract>A series of novel 3,4,5-trimethoxycinnamamide-tethered 1,2,3-triazole derivatives were prepared by the click reaction of (
E
)-
N
-(prop-2-yn-1-yl)-3-(3,4,5-trimethoxyphenyl) acrylamide with different aryl azides. The synthesized compounds were characterized by
1
H and
13
C NMR and mass spectra and elemental analyses and were screened for their in vitro anticancer activity against MCF-7 and A549 cell lines by using MTT assay. Most of the tested compounds showed prominent activity against both cancer cell lines.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1070428022010122</doi><tpages>7</tpages></addata></record> |
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| subjects | Acrylamide Anticancer properties Cancer Chemical reactions Chemistry Chemistry and Materials Science Mass spectra NMR Nuclear magnetic resonance Organic Chemistry Triazoles |
| title | Synthesis and Anticancer Activity of 3,4,5-Trimethoxycinnamamide-Tethered 1,2,3-Triazole Derivatives |
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