Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11C‐UCB‐J positron emission tomography study in humans

Preclinical studies have revealed robust and long‐lasting alterations in dendritic spines in the brain following cocaine exposure. Such alterations are hypothesized to underlie enduring maladaptive behaviours observed in cocaine use disorder (CUD). The current study explored whether synaptic density...

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Veröffentlicht in:	Addiction biology 2022-03, Vol.27 (2), p.n/a
Hauptverfasser:	Angarita, Gustavo A., Worhunsky, Patrick D., Naganawa, Mika, Toyonaga, Takuya, Nabulsi, Nabeel B., Li, Chiang‐Shan R., Esterlis, Irina, Skosnik, Patrick D., Radhakrishnan, Rajiv, Pittman, Brian, Gueorguieva, Ralitza, Potenza, Marc N., Finnema, Sjoerd J., Huang, Yiyun, Carson, Richard E., Malison, Robert T.
Format:	Artikel
Sprache:	eng
Schlagworte:	addictive behaviours anterior cingulate cortex Cocaine cocaine use disorder Cortex (cingulate) Dendritic spines medial orbitofrontal cortex Neostriatum PET imaging Positron emission tomography Prefrontal cortex Synaptic density synaptic vesicle glycoprotein 2A Tomography ventromedial prefrontal cortex
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