Pyrrolidine-based cationic γ-peptide: a DNA-binding molecule works as a potent anti-gene agent

Pyrrolidine-based cationic peptides showing high stability to enzyme degradation and strong binding affinity towards DNA are widely investigated as tools to interfere in gene expression. Several studies have been focused on γ-peptide analogs with modifications on the peptide backbone in the attempt...

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Veröffentlicht in:	Medicinal chemistry research 2022-03, Vol.31 (3), p.507-516
Hauptverfasser:	Preetham, Habbanakuppe D., Umashankara, M., Kumar, Kothanahally S. Sharath, Rangappa, Shobith, Rangappa, Kanchugarakoppal S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Backbone Binding Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Cationic peptides Cations Chains Conformation Deoxyribonucleic acid DNA Electrophoretic mobility Gene expression Inorganic Chemistry Medicinal Chemistry Molecular conformation Nucleic acids Original Research Peptides Pharmacology/Toxicology Plasmids Protein structure Reagents Secondary structure Transfection
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