Organic photoredox catalytic amino-heteroarylation of unactivated olefins to access distal amino ketones

Here we describe a metal-free amino-heteroarylation of unactivated olefins via organic photoredox catalysis, providing a concise and efficient approach for the rapid synthesis of various δ (β, )-amino ketones under mild conditions. This protocol demonstrates that the new photocatalyst Cz-NI developed by our group has an excellent photoredox catalytic performance. Finally, a series of mechanistic experiments and DFT calculations indicate that this transformation undergoes a photoredox catalytic sequential radical addition/functional group migration process. A metal-free amino-heteroarylation of unactivated olefins via new organic photoredox catalysis was reported, providing a concise and efficient approach for the rapid synthesis of various δ (β, )-amino ketones under mild conditions. A series of mechanistic experiments and DFT calculations indicate that this transformation undergoes a photoredox catalytic sequential radical addition/functional group migration process.